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Rybelsus is an oral tablet version of the drug semaglutide, prescribed for treating Type 2 diabetes. Rybelsus is taken daily to help control blood sugar levels in adults. It can also be prescribed to help weight loss.

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Rybelsus Brand 14mg
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Rybelsus is a new pill-form drug for treating Type 2 diabetes containing semaglutide – the same substance as in Ozempic.  Rybelsus is an oral tablet version of semaglutide taken daily. Ozempic is an injectable form of the same medication taken once each week.  Semaglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist. GLP-1 is a hormone produced in the gut. It is released in response to food, prompting the release of insulin and a reduction in appetite.  In the case of people with Type 2 diabetes, semaglutide works to slow down digestion. This stimulates the increased production of natural insulin. Rybelsus doesn’t work like other treatments of diabetes, that boost insulin levels from external sources (injection or oral insulin).  If you have been diagnosed as clinically obese, your doctor may prescribe Rybelsus as a weight-loss treatment along with appropriate diet controls and exercise. The primary effect of Rybelsus in this mode is as an appetite suppressant.

When starting treatment, the most common side effects of Rybelsus may include nausea, abdominal pain, diarrhea, decreased appetite, vomiting, or constipation. These should gradually decrease over the first few weeks. Talk to your doctor or pharmacist if symptoms do not go away or get worse.

Rybelsus may also cause serious side effects, including:

  • Pancreatitis (inflammation of the pancreas). If you have severe pain in your stomach area that does not go away, with or without vomiting. You may feel the pain radiating from your abdomen into your back
  • Changes in vision
  • Hypoglycemia (low blood sugar levels). The risk of hypoglycemia may increase if you use Rybelsus along with other medicines that can cause blood sugar levels to drop, such as sulfonylurea or insulin. Signs and symptoms of hypoglycemia may include: dizziness or lightheadedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery
  • Kidney failure. In people with kidney problems, side effects of Rybelsus, like diarrhea, nausea, or vomiting, can result in dehydration, which may cause kidney problems to get worse. You need to drink fluids to help reduce the chance of dehydration
  • Severe allergic reactions like swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat
  • Gallbladder problems like pain in the upper abdomen, yellowing of skin or eyes (jaundice), fever, and clay-colored stools.

Stop using Rybelsus and get medical help right away, if you have any of these symptoms.

Rybelsus has also been reported as causing thyroid tumors, including cancer, in animal studies. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. 

It is unknown whether Rybelsus will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. However, do not use Rybelsus if you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome Type 2 (MEN 2).

For pregnant women, there is a potential risk to a fetus. Advise your doctor if you are pregnant or intend to become pregnant. If you are already on Rybelsus, discontinue treatment at least two months before a planned pregnancy due to the long washout period for semaglutide. 

Mothers should not breastfeed during treatment with Rybelsus.

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Rybelsus is prescribed to improve glycemic control in adults with Type 2 diabetes mellitus, along with an adjunct diet and exercise treatment. 

As well as its effectiveness in controlling blood-sugar levels without insulin, Rybelsus acts to lower the levels of A1C – the most effective test for diagnosis of prediabetes and tracking the development of diabetes.

Once-daily doses of Rybelsus, along with diet and exercise, have been proven to significantly lower A1C. 

Rybelsus and weight-loss

Rybelsus has been shown to help people lose some weight when used along with diet and exercise. 

Dosage and Administration

Rybelsus comes in the form of white to light yellow oval-shaped pills debossed with the mg strength on one side and “novo” on the other side. The three dosages are:

  • Rybelsus 14mg
  • Rybelsus 7mg
  • Rybelsus 3mg

Your prescribing doctor will start you off on the lower dosage, and the dosage will then be increased according to the doctor’s recommendations.

You should take Rybelsus on an empty stomach when you wake up first thing in the morning. (If you have a different sleep cycle, like for shift work, you should leave at least 5-6 hours of no food or drink intake before taking the pill.) An empty stomach means no food, drink, oral medications, vitamins, or supplements.

Take a single pill with a sip of no more than 4 ounces of plain water.

Wait 30 minutes before you eat, drink, or take other oral medications, vitamins, or supplements.

If you miss a dose and have eaten, the missed dose should be skipped, and the next dose should be taken the following day at the regular time. Do not double-dose to make up for a missed dose.

  • How does Rybelsus work?
    Rybelsus is a medication that belongs to a class of drugs called GLP-1 receptor agonists. These drugs mimic a hormone that promotes insulin production by the pancreas, thus lowering blood sugar, suppressing appetite, and slowing down digestion, preventing rapid blood sugar spikes after a meal. Rybelsus helps manage type 2 diabetes and is often prescribed off-label to treat obesity. Make sure to consult a healthcare provider before taking this drug.
  • What is the difference between Rybelsus and other GLP-1 medications?
    Rybelsus, like other GLP-1 medications, mimics the GLP-1 hormone that promotes the production of insulin. This aids with blood sugar control for type 2 diabetes, suppressing appetite, slowing digestion, and lowering blood sugar. Rybelsus is unique in that it is taken as an oral tablet once a day 30 minutes before a meal. It is taken on an empty stomach. Other GLP-1 medications are delivered primarily through injections once a week or daily.
  • Is Rybelsus safe for long-term use?
    Clinical trials tracked patients taking Rybelsus for up to 2 years, showing no significant risk of major adverse events. Furthermore, side effects caused by this medication (like nausea, vomiting, and diarrhea) are considered mild and temporary. It is important to note that all GLP-1 agonist drugs can increase the risk of thyroid tumors. Consult a healthcare provider or pharmacist before and while taking Rybelsus.
  • What is the starting dose of Rybelsus?
    The starting dose of Rybelsus is 3 mg once daily, at least 30 minutes before the day's first meal. It is important to start with low doses to familiarize the body with the medication and potentially minimize side effects.
  • What if I miss a dose of Rybelsus?
    If a dose is missed by a few hours, the recommendation is to take the missed dose as soon as possible. If the dose was missed by a day, continue taking the prescribed dose regularly. Do not take two doses to ‘make up’ for the forgotten one. If multiple doses are missed, make sure to consult your healthcare provider.
  • Can I cut or crush Rybelsus tablets?
    Rybelsus tablets should never be cut, chewed, or crushed. These actions can impact the way this medication works. Rybelsus comes in specific doses - 3 mg, 7 mg, and 14 mg so cutting or altering the tablet makes it impossible to ensure that the right dose will be taken.
  • What are the most common side effects of Rybelsus?
    The most common side effects are gastrointestinal: nausea, diarrhea, vomiting, abdominal pain, gas, bloating, and constipation. Some people may experience headaches, dizziness, and fatigue. These side effects are usually mild and temporary. Consult a healthcare provider with any concerns or discomfort caused by this medication.
  • Can Rybelsus help me lose weight?
    Rybelsus has been reported to aid with weight loss by lowering appetite and blood sugar. However, it is important to understand that Rybelsus was not created as a weight loss drug per se; it is approved for treating type 2 diabetes. During clinical trials on the drug, its effectiveness as a weight-loss tool was discovered.
  • Does Rybelsus interact with other medications?
    Rybelsus can interact with medications that control blood sugar - other diabetes medications, corticosteroids, thyroid medications, digestive medications, and blood pressure medications. One should always consult their healthcare provider before takingRybelsus so they can be made aware of any other medications or supplements that could interfere with the treatment.

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