Repatha (generic name: evolocumab) is a prescription medication classified as a PCSK9 inhibitor, a type of monoclonal antibody. It is designed to lower low-density lipoprotein cholesterol (LDL-C) levels in the blood. By inhibiting the PCSK9 protein, Repatha increases the number of LDL receptors on liver cells, enhancing the clearance of LDL-C from the bloodstream.
Evolocumab is approved for use in adults with heterozygous familial hypercholesterolemia (HeFH) or homozygous familial hypercholesterolemia (HoFH), both genetic conditions characterized by high cholesterol levels. It is also indicated for patients with established cardiovascular disease to reduce the risk of heart attack, stroke, and coronary revascularization. Additionally, Repatha is used as an adjunct to diet and maximally tolerated statin therapy in patients who require additional LDL-C lowering.
Dosage
The doctor will determine the dosage and treatment. Do not exceed the prescribed dose. Read the Product Information leaflet for full instructions on how to administer the dose.
Storage
Repatha should be stored in its original container under refrigeration at 36-46°F (2-8°C). If necessary, it may be kept out of the refrigerator at room temperature below 77°F/25°C for up to 30 days, but once removed from refrigeration, it should not be returned and must be used within 30 days or discarded.
Do not use if any part of the pre-filled syringe or pen appears cracked or broken, if the grey needle cap on the pre-filled syringe is missing or not securely attached or if the medicine is discolored or contains large lumps, flakes or colored particles. If you are in any doubt, consult a doctor or pharmacist bfore using Repatha.
Questions about Repatha
How is Repatha administered?
Repatha is administered as a subcutaneous injection using a prefilled syringe, autoinjector, or on-body infusor. The injection is typically given in the thigh, abdomen, or upper arm. Patients or caregivers can be trained to administer the injections at home.
Can Repatha be used alone?
Repatha is usually used in combination with a healthy diet and maximally tolerated statin therapy. It is not typically used as a standalone treatment but may be considered in patients who cannot tolerate statins.
How does Repatha help in cardiovascular disease?
By lowering LDL-C levels, Repatha reduces the risk of cardiovascular events such as heart attacks and strokes in patients with established cardiovascular disease.
This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication.
Read the information leaflet that comes with the medication.
Most people who use Repatha do not experience any adverse side effects. Doctors prescribe this medication because they assess the benefits of such treatment outweigh any likely unwanted effects.
If a sudden allergic reaction (anaphylaxis) occurs after taking Repatha, with symptoms like swelling of the face, tongue, or throat making it difficult to breathe or swallow, or there is wheezing, hives, rash, blistering, or peeling of the skin, call a doctor or 911 right away, or go to an emergency room immediately.
Some of the side effects that have been reported include:
- Injection site reactions: Redness, pain, or bruising at the injection site.
- Upper respiratory tract infections: Runny nose, sore throat, and flu-like symptoms.
- Back pain: Discomfort or pain in the back.
- Urinary tract infections: Increased frequency or urgency of urination, burning sensation during urination.
- Muscle pain: Myalgia or muscle spasms.
- Diarrhea: Gastrointestinal discomfort.
Not all side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.
Repatha can be used to lower cholesterol in adults with several conditions:
- High cholesterol: This includes both inherited (familial) and non-inherited forms.
- Mixed dyslipidemia: High levels of bad cholesterol (LDL) and other unhealthy fats in the blood.
Repatha is usually used along with a healthy diet:
- For people who can’t reach their target LDL-C level with the highest safe dose of a statin medication. Statins are another type of cholesterol-lowering drug. Repatha may be combined with a statin or other cholesterol-lowering medications.
- For people who can’t take statins at all. This could be because of side effects or other medical conditions.
Repatha can also be used in these cases:
- For children aged 12 and over with a severe inherited form of high cholesterol (homozygous familial hypercholesterolemia). It’s used along with other cholesterol-lowering medications.
- For adults with a history of heart attack, stroke, or peripheral arterial disease. Repatha helps lower their risk of future heart problems by reducing LDL-C levels.
Important information:
- Before using Repatha, be sure to read the information leaflet provided by your pharmacist.