Why is Rapamune used specifically for kidney transplants?

Rapamune was tested and approved mainly for people who have received a kidney transplant. While it suppresses the immune system like other drugs, its specific approval is for kidneys because studies showed it works best in this setting. It is often used with other medicines to create a 'cocktail' that protects the new organ. This combination allows doctors to use lower doses of other strong drugs, which helps reduce the risk of side effects that can damage the kidneys over time. This balance is key for long-term kidney health and avoiding failure of the new organ.

How does sirolimus work in the body?

Sirolimus works by blocking a specific signal inside cells. Normally, this signal tells the immune system's white blood cells to grow and multiply when they see something foreign, like a new kidney. By blocking this signal, sirolimus stops these cells from increasing in number. This quiets the immune response just enough so that it does not attack the transplant. However, it tries to leave enough of the immune system working to help you fight off ordinary germs, though there is still need to be careful about infections. It balances protection of the kidney with overall health.

Is sirolimus a type of steroid?

No, sirolimus is not a steroid. It belongs to a different family of medicines called mTOR inhibitors. Steroids are often used in transplants too, but they work by reducing inflammation in the whole body. Sirolimus works in a more targeted way by stopping cells from dividing. This is good news because it means sirolimus does not cause some of the common steroid side effects, like bone loss or puffiness in the face. However, it has its own set of side effects that a doctor will watch for carefully during treatment.

Why is Rapamune used for kidney transplants?

Rapamune was tested and approved mainly for recipients of a kidney transplant. While it suppresses the immune system like other drugs, its specific approval is for kidneys because studies showed it works effectively in this setting. It is often used with other medicines to create a combination treatment that protects the new organ. This method allows doctors to use lower doses of other strong drugs, which helps reduce the risk of side effects that can damage the kidneys over time. This careful balance is a key part of long-term kidney health after a transplant.

Will sirolimus change cholesterol levels?

Yes, it is very common for sirolimus to raise the levels of cholesterol and fats (triglycerides) in the blood. This happens because the drug changes how the body processes fats. A doctor will check the patient’s lipid levels with blood tests regularly. If the levels get too high, a patient might need to change diet to eat fewer fatty foods or start an exercise plan. In some cases, a doctor might prescribe medicine to help lower cholesterol to keep the heart and blood vessels healthy while the drug is taken for the kidney.

Can vaccines be received while on this medicine?

Caution is necessary with vaccines while taking mTOR inhibitors. Most vaccines that use 'killed' or inactive germs, such as the yearly flu shot, are usually considered safe, although they might not work as well because the immune system is less active. However, 'live' vaccines, like those for measles or chickenpox, should be strictly avoided. Because the immune system is suppressed, a live vaccine could cause the actual disease. A patient must always consult the transplant doctor before receiving any vaccination to ensure it is safe for the specific medical situation.

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Home / Online Pharmacy / Rapamune

For visual reference only; actual product may vary

US Name:

Rapamune
Alternative Names:

Rapamune, Rapamycin
Active Ingredients:

Sirolimus
Brand Manufacturer:

Pfizer
Manufacturer Location:

Ireland
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Rapamune ^*

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Rapamune is taken to prevent rejection of a kidney transplant

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Rapamune Brand	0.5mg 30 Tablets	- Rapamune – Brand, Rapamune, 0.5mg, 30, Tablets, 555555, Pfizer, 2529 + 0	Our price: $220.00
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Description
Side Effects
Indications
FAQ
Video

Rapamune (generic name: sirolimus) can be prescribed to treat the prevention of organ rejection in patients aged 13 years or older receiving a kidney transplant. It works by lowering the strength of the body’s natural defense system to help the body accept the new kidney. The drug belongs to a pharmacological class of medicines known as mTOR inhibitors. It is most often used in combination with other medicines, such as corticosteroids, to provide the best chance for the transplant to succeed over the long term. Sirolimus is a medicine derived from natural soil bacteria that acts on the immune system. It blocks a specific signal within cells that normally tells the immune system’s white blood cells to grow and attack foreign objects. By stopping these signals, the generic drug prevents the defense cells from damaging the new organ. This action is different from how other common transplant medicines work, providing a unique method of protection. Doctors prescribe this drug for the long-term management of a new kidney after surgery. Treatment typically begins with a higher initial dose right after the operation, followed by a lower daily maintenance dose. It is vital that the medicine is taken the same way every day, either always with food or always without, so the body absorbs it evenly. Medical teams check blood samples frequently to measure drug levels. This monitoring allows doctors to adjust the dose as needed, keeping the treatment both safe and effective for the patient’s care.

Dosage

It is important to follow the dosage instructions printed on the label of the box. Check with a doctor or pharmacist if there are any doubts regarding the proper dosage and treatment regimen. Tablets must be swallowed whole with water; they should not be crushed, chewed, or split. The medicine must be taken once daily at the same time. A patient must take the dose consistently either with food or without food. Grapefruit or grapefruit juice must be avoided, as it changes drug absorption. If a dose is missed, it should be taken as soon as remembered. If the next scheduled dose is due in less than 12 hours, the missed dose is skipped. Two doses must never be taken at the same time. This medicine is usually taken for the long term to protect the kidney.

Storage

Store the box at room temperature, between 20-25°C (68-77°F). Keep the blister packs away from bright light and moisture. Always check the expiry date on the package. The medicine must be kept out of the reach of children. For more information, read our article on drug storage.

This text is for informational purposes only. Please consult a doctor or pharmacist before using this medication.

The patient information leaflet that is included with Rapamune includes full information about the correct usage, storage and possible side effects. Be sure to read and understand these, and if there are any questions, discuss these with a healthcare provider or pharmacist before starting treatment.

Caution

If a sudden allergic reaction (anaphylaxis) occurs shortly after taking Rapamune, with symptoms like swelling of the face, tongue, or throat making it difficult to breathe or swallow, or there is wheezing, hives, rash, blistering, or peeling of the skin, call a doctor or 911 right away, or go to an emergency room immediately.

Pregnant women should not be using Rapamune unless this has been discussed with a healthcare provider, as it might harm the unborn baby or pose a risk of miscarriage. For this reason, women planning to become pregnant should use appropriate birth control measures during the treatment and one month after taking the last dose of Rapamune.

Most people who use Rapamune do not experience any adverse side effects. Doctors prescribe this medication because they assess the benefits of such treatment outweigh any likely unwanted effects.

Common side effects

Swelling in the hands, feet, or legs due to fluid buildup.
High blood pressure.
Increased levels of cholesterol and triglycerides in the blood.
Stomach pain, constipation, diarrhea, or nausea.
Acne or a skin rash.
Sores in the mouth (stomatitis) or ulcers.
Headache or joint pain.
Urinary tract infections.

Serious side effects that require immediate action

Signs of infection such as fever, chills, or a persistent sore throat.
Symptoms of lung disease, including new or worsening cough or trouble breathing.
Decreased kidney function, indicated by little or no urine.
Unusual bruising or bleeding.

Not all the known side effects of Rapamune are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.

Rapamune is prescribed to prevent the body from rejecting a kidney transplant. It is meant for adults and teenagers who have a low to moderate risk of rejection. The goal is to quiet the immune system so it accepts the donor kidney.

Symptoms of Kidney Rejection

Rejection happens when the immune system attacks the new kidney. Watch for these symptoms:

Fever: A temperature over 38°C (100°F) is often the first sign that the body is fighting the new organ.
Pain directly over the area where the new kidney was placed.
Swelling: If the kidney is not removing fluid well, there may be swelling of the hands or feet.
Urine Changes: A sudden drop in the amount of urine, or urine that looks very dark.
Flu-like Feelings: Feeling chills, body aches, headaches, or nausea.
General Malaise: A general sense of being tired, weak, or sick can be a warning sign.

Rapamune was tested and approved mainly for people who have received a kidney transplant. While it suppresses the immune system like other drugs, its specific approval is for kidneys because studies showed it works best in this setting. It is often used with other medicines to create a "cocktail" that protects the new organ. This combination allows doctors to use lower doses of other strong drugs, which helps reduce the risk of side effects that can damage the kidneys over time. This balance is key for long-term kidney health and avoiding failure of the new organ.
Sirolimus works by blocking a specific signal inside cells. Normally, this signal tells the immune system's white blood cells to grow and multiply when they see something foreign, like a new kidney. By blocking this signal, sirolimus stops these cells from increasing in number. This quiets the immune response just enough so that it does not attack the transplant. However, it tries to leave enough of the immune system working to help you fight off ordinary germs, though there is still need to be careful about infections. It balances protection of the kidney with overall health.
No, sirolimus is not a steroid. It belongs to a different family of medicines called mTOR inhibitors. Steroids are often used in transplants too, but they work by reducing inflammation in the whole body. Sirolimus works in a more targeted way by stopping cells from dividing. This is good news because it means sirolimus does not cause some of the common steroid side effects, like bone loss or puffiness in the face. However, it has its own set of side effects that a doctor will watch for carefully during treatment.
Rapamune was tested and approved mainly for recipients of a kidney transplant. While it suppresses the immune system like other drugs, its specific approval is for kidneys because studies showed it works effectively in this setting. It is often used with other medicines to create a combination treatment that protects the new organ. This method allows doctors to use lower doses of other strong drugs, which helps reduce the risk of side effects that can damage the kidneys over time. This careful balance is a key part of long-term kidney health after a transplant.
Yes, it is very common for sirolimus to raise the levels of cholesterol and fats (triglycerides) in the blood. This happens because the drug changes how the body processes fats. A doctor will check the patient’s lipid levels with blood tests regularly. If the levels get too high, a patient might need to change diet to eat fewer fatty foods or start an exercise plan. In some cases, a doctor might prescribe medicine to help lower cholesterol to keep the heart and blood vessels healthy while the drug is taken for the kidney.
Caution is necessary with vaccines while taking mTOR inhibitors. Most vaccines that use "killed" or inactive germs, such as the yearly flu shot, are usually considered safe, although they might not work as well because the immune system is less active. However, "live" vaccines, like those for measles or chickenpox, should be strictly avoided. Because the immune system is suppressed, a live vaccine could cause the actual disease. A patient must always consult the transplant doctor before receiving any vaccination to ensure it is safe for the specific medical situation.

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