What is Orencia?
Orencia is a prescription biologic medication used to treat several autoimmune conditions. Its active ingredient is abatacept. It is primarily prescribed for adults with moderate to severe rheumatoid arthritis or psoriatic arthritis. Orencia is also used for polyarticular juvenile idiopathic arthritis in children. This medication helps reduce underlying inflammation. It aims to prevent joint damage and improve physical function over time. It is considered a long-term management therapy.
How does Orencia work?
Orencia works by targeting a specific part of the immune system. It is a selective T-cell costimulation modulator. T-cells are a type of white blood cell involved in inflammation. For T-cells to become fully active and attack the body’s own tissues, they need two signals. Orencia blocks the second signal. It does this by binding to proteins called CD80 and CD86 on the surface of other immune cells. By preventing this connection, Orencia stops T-cells from activating. This reduces the inflammatory process that causes joint pain, swelling, and damage in autoimmune arthritis.
Who is Orencia for?
Orencia is for patients with certain inflammatory autoimmune disorders. It is approved for adults with moderate to severe rheumatoid arthritis (RA). Many of these patients have not responded well to other treatments. It is also used for adults with active psoriatic arthritis (PsA) to help with both joint and skin symptoms. Furthermore, Orencia can be prescribed for children aged two years and older. These children have moderate to severe polyarticular juvenile idiopathic arthritis (pJIA). A rheumatologist will determine if Orencia is a suitable treatment based on the specific condition, disease activity, and medical history.
Dosage and administration
Orencia dosage and administration depend on the patient and the condition being treated. The medication is given as a subcutaneous injection (under the skin) or an intravenous (IV) infusion. The subcutaneous injection is typically administered once a week, on the same day each week. The usual dose for adults is 125 mg. Patients can be taught to inject it themselves at home using a pre-filled syringe or autoinjector. The IV infusion is administered by a healthcare professional. Dosing for IV infusions is based on body weight. If you miss a dose, take it as soon as you remember. Do not take two doses at the same time to make up for a missed one.
Side effects
Orencia may cause side effects, though not everyone experiences them. The most common side effects are usually mild. They can include headaches, nausea, and upper respiratory tract infections like a cold. Some people experience reactions at the injection site, such as redness or itching. While less common, serious side effects are possible. Orencia affects the immune system, which can increase the risk of serious infections. Symptoms of a serious infection include fever, chills, or a persistent cough. In rare cases, severe allergic reactions can occur. It is important to discuss all potential risks with your doctor before starting treatment.
Why buy from IsraelPharm?
IsraelPharm offers a reliable and affordable way to get your prescription medications. We provide authentic Orencia manufactured by Bristol Myers. Our platform makes it easy to order your treatment from the comfort of your home. We are dedicated to providing excellent customer service and support. Our pharmacy team can help answer your questions. We ensure that your medication is sourced, stored, and shipped according to the highest standards. You receive the same quality medication you would from a local pharmacy but at a more competitive price. Trust IsraelPharm for your long-term health needs.
Always consult your doctor for medical advice about side effects. This list is not exhaustive.
Common Side Effects
Most common side effects are mild to moderate.
- Headache
- Nausea
- Upper respiratory tract infections (e.g., cold, sinus infection)
- Cough
- Injection site reactions (for subcutaneous form)
Serious Side Effects
Contact your doctor immediately if you experience any of these.
- Serious Infections: Orencia can lower your ability to fight infections. This includes tuberculosis and other bacterial, viral, or fungal infections.
- Allergic Reactions: Symptoms can include rash, itching, hives, and swelling of the face, eyelids, lips, or tongue.
- Worsening of COPD: Patients with COPD may have an increased risk of respiratory side effects.
- Increased risk of certain cancers.
Orencia is prescribed for a range of immune-mediated joint conditions.
Rheumatoid Arthritis (RA)
This is an autoimmune disease where the immune system attacks joint linings. It causes inflammation, pain, and can lead to permanent damage.
- Symptoms include: joint swelling, persistent pain, and morning stiffness.
Psoriatic Arthritis (PsA)
In PsA, the immune system causes inflammation in both the skin and joints. Orencia can help manage joint and skin symptoms.
- Symptoms include: joint pain and swelling, sometimes with sausage-like fingers or toes.
Polyarticular Juvenile Idiopathic Arthritis (pJIA)
Orencia is used for this condition in children aged two and older. It involves arthritis in five or more joints.
- Symptoms include: joint pain and swelling that can affect mobility and daily activities.