Nexletol / Nilemdo (generic name: bempedoic acid) is a prescription medication used to help lower LDL-C cholesterol (“bad” cholesterol) levels in adults with specific heart or cholesterol conditions. Bempedoic acid works by inhibiting an enzyme called ATP-citrate lyase, which plays an essential role in the liver’s production of cholesterol. By blocking this enzyme, Nexletol reduces the amount of cholesterol produced by the liver, thus lowering the overall level of LDL cholesterol in the bloodstream. Lowering LDL cholesterol is crucial for reducing the risk of heart attack, stroke, and other cardiovascular events in individuals who have difficulty controlling their cholesterol levels through diet and statins alone. Nilemdo is FDA-approved for individuals with heterozygous familial hypercholesterolemia (HeFH) or established atherosclerotic cardiovascular disease (ASCVD) for whom diet and maximally tolerated statins are insufficient to lower their cholesterol levels. Bempedoic acid offers an alternative treatment for patients who may not tolerate high doses of statins due to muscle pain or other side effects. Other drugs in the same class, such as Nexletol or Nexlizet  (which combines bempedoic acid with ezetimibe), are also commonly prescribed to manage cholesterol levels. The prescribing physician determines the choice between these options based on the patient’s specific needs.

Caution

Nelextol has not been fully tested on pregnant women. Pregnant women or those planning to become pregnant should consult their healthcare provider before starting this medication.

Dosage

Follow the healthcare provider’s instructions on dosing. Patients should not stop taking Nexletol without consulting their doctor, even if their cholesterol levels improve. The standard dosage of Nexletol is one 180 mg tablet taken once daily, with or without food. It should be taken at the same time each day. If a dose is missed, it can be taken on the due day as soon as realized, but if not, do not double-dose the next day to make up for a missed dose.

Storage

Store Nilemdo at room temperature but not higher than 25°C / 77°F. Keep the medication in its original container, tightly closed, and out of reach of children. For further guidance on proper handling, consult our blog on safe medicine management.

FAQ

How long does it take for Nexletol to lower cholesterol?

Nexletol typically starts to lower cholesterol levels within four weeks, but it may take longer to see the full benefits. Regular blood tests are needed to monitor progress.

Can Nexletol be taken with statins?

Yes, Nexletol is often prescribed alongside statins for individuals who need additional cholesterol-lowering therapy. However, following the prescribing physician’s instructions and reporting any side effects is essential.

Does Nexletol have the same muscle-related side effects as statins?

Nexletol is less likely to cause muscle-related side effects than statins, but some patients may still experience muscle spasms or discomfort. Consult your healthcare provider if these symptoms occur.