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    Klisyri Ointment

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Klisyri Ointment

Prescription Required

Klisyri Ointment is prescribed for the treatment of actinic keratosis of the face or scalp in adults.

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Klisyri Ointment Brand 1%
5 Single-dose packets
Our price: $171.00

*Please note all prices are in US dollars
Klisyri Ointment (tirbanibulin) is prescribed for the treatment of actinic keratosis of the face or scalp in adults. Tirbanibulin is classified as a non-ATP competitive Src kinase inhibitor and tubulin polymerization inhibitor. Src inhibitors can potentially reduce the rate of malignant transformations of certain cells. Tubulin polymerization inhibitors stop or slow down cell division and movement, and so can also prevent the progression of some cancers. Actinic keratosis is a common pre-malignant skin condition, usually developing on the face and scalp when there has been prolonged exposure to sunlight or ultraviolet light. It can develop into squamous cell carcinoma, which makes early detection and treatment important. The condition is typically diagnosed based on the clinical appearance of the patches that have developed keratolytic scaling, but a skin biopsy may sometimes be ordered to confirm the diagnosis. Klisyri Ointment is the only 5-days topical treatment for actinic keratosis.


Follow the instructions of the prescribing healthcare professional. The usual treatment is to apply Klisyri ointment to evenly cover all the treatment areas on the face or scalp once each day for five consecutive days, using a single dose packet with each application. These areas should not then be covered with dressings. Take care not to touch the eyes while there is still ointment on your fingers. Wash hands with soap and water as soon as the ointment has been applied. Avoid washing and touching the treated area for approximately eight hours after application of the ointment. Subsequently, the areas can be washed with a mild soap and water. Throw away the open packet of Klisyri after application, even if there is some ointment still left in it.    

This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication. 

Read the information leaflet that comes with the medication.

Most people who use Klisyri ointment do not experience any negative side effects. Doctors prescribe Klisyri ointment because they assess that the benefits that such treatment yields outweighs any likely unwanted effects.

Some of the side effects that have been reported include itching, pain and irritation at the areas where ointment has been applied. If there are other side effects such as redness, flaking or scaling, crusting, or more severe swelling, development of blisters, peeling, pus, ulcers, or breakdown of the skin, see a doctor as soon as possible.

Not all side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.

Actinic keratosis usually develops slowly over time. It is much more common in older people, and also in people who suffered one or more severe sunburns when younger.

It commonly shows up on areas of the skin that are frequently exposed to the sun, such as the face, ears, bald scalp, neck, hands, forearms, and lips. While the lesions typically lie flat on the skin of the head and neck, they can appear as raised bumps on the arms and hands. The color of an actinic keratosis patch may vary from light to dark shades like tan, pink, red, or a mix of these colors. The texture can be rough, with dry and scaly patches. Occasionally, it might cause itching or prickly discomfort.

It’s common for individuals to have multiple actinic keratosis lesions. When these occur on the lips specifically, they are referred to as actinic cheilitis.

Actinic keratosis may need to be diagnosed by means of a skin biopsy.

Damage to the skin from UV rays builds up over time. This means that even short-term exposure to the sun regularly can build up over a lifetime and increase the risk of actinic keratoses. Some people are more at risk than others, including:

  • People with pale skin, blonde or red hair, and blue, green, or gray eyes
  • People with darker skin, hair, and eyes who have been exposed to UV rays without protection
  • Older adults
  • People with suppressed immune systems (due to chemotherapy, AIDS, organ transplant, or other causes)
  • People with rare conditions that make the skin very sensitive to UV rays, such as albinism or xeroderma pigmentosum (XP)
  • Is actinic keratosis a cancer?
    Actinic keratosis caused by long-term damage from the sun shows up as an abnormal growth of cells on the outer layer of the skin. The lesions are not themselves cancerous, but some of them can develop into squamous carcinoma (skin cancer). Because there is no way of predicting which ones will become cancerous, dermatologists recommend treatment of all detected lesions,
  • What are the red flags for actinic keratosis?
    Only a small proportion of keratolytic lesions turn cancerous. The warning signs are changes in color, to pink, red, or brown as well as starting to itch, burn, bleed or flake.
  • What happens if actinic keratosis is left untreated?
    Actinic keratosis (AK) shows up as rough, scaly skin patches, usually on the head or face. If left untreated, it can lead to the development of squamous cell carcinoma.
  • What percentage of actinic keratosis turn into cancer?
    Actinic keratoses have the potential to progress to squamous cell carcinomas (SCCs). About 10% of people who have developed actinic keratosis will progress to squamous cell carcinomas. SCCs are the second most common types of cancer in the US, with more than 200,000 new cases each year.

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