Elestat / Relestat (generic name: epinastine hydrochloride) ophthalmic solution is an antihistamine and mast cell stabilizer prescribed to alleviate the itching and discomfort associated with allergic conjunctivitis. Allergic conjunctivitis is an eye inflammation caused by allergens, leading to symptoms such as redness, swelling, and tearing. Epinastine functions by inhibiting the release of histamine and other inflammatory substances from mast cells, thereby reducing allergic reactions in the eyes. Epinastine is classified as a second-generation antihistamine, which means it selectively targets histamine H1 receptors and is less likely to cross the blood-brain barrier. This reduces the risk of central nervous system side effects like drowsiness. Its dual action as an antihistamine and mast cell stabilizer makes it effective in immediate and delayed allergic responses.

Dosage

The typically recommended use of Elestat is to instill one drop in each affected eye twice daily, normally administered in the morning and evening. Contact lenses should be removed before installation and may be reinserted after 10 minutes. To maintain its preventive effects, continuing the treatment throughout the prescribed period is important, even if symptoms are absent. However, usage beyond that is discouraged. Elestat should not be used for more than eight weeks without consulting a doctor.

Storage

The solution should be stored at room temperature, away from light and moisture, and the bottle should be kept tightly closed when not in use. If in any doubt, consult our blog on safe medicine management.

Common Questions About Elestat

Are there any warnings I should be aware of?

Epinastine should not be used if the eyes are red due to contact lens irritation, and the dropper tip should not be allowed to touch any surface to avoid contamination.

Can Elestat be used for conditions other than allergic conjunctivitis?

Epinastine is FDA-approved for allergic conjunctivitis. There are no widely accepted off-label uses for this medication.

How does epinastine work?

Epinastine works by blocking histamine receptors in the eyes and stabilizing mast cells, preventing the release of histamine and other substances that cause inflammation and itching.