Some women notice a change in sexual desire after menopause. This can be confusing, frustrating, and sometimes upsetting. It often has less to do with how a person feels about their partner and more to do with changes happening inside the body. One of the main causes is estrogen deficiency, which leads to uncomfortable vaginal changes. These changes can make sex less enjoyable, or even painful. Rather than simply giving up on one of the great features of partnerships, it’s certainly worth investigating a simple path that can raise sex drive and libido.
One treatment that’s been helpful for many women is Vagifem, a low-dose vaginal tablet containing estradiol. It’s often recommended as a simple hormone replacement treatment that doesn’t even require a prescription, and it can also support sexual health in other ways. For many women, it is the first step towards increasing comfort and restoring interest in sex.
Sexual desire isn’t controlled by one thing alone. It’s influenced by:
- Hormonal imbalance, especially shifts in estrogen and testosterone during menopause
- Changes in vaginal lubrication, elasticity, and blood flow
- Psychological effects of menopause, such as stress, anxiety, or sleep trouble
- How confident and comfortable a person feels in their body.
What does Vagifem do in the body?
Vagifem is a local hormone replacement therapy. It delivers a small dose of estrogen directly into the vaginal tissues, without spreading much into the rest of the body.
Its main effects include:
- Improving vaginal lubrication, making the area feel less dry or irritated
- Thickening and strengthening the vaginal walls to relieve vaginal atrophy
- Helping with postmenopausal symptoms like itching, burning, or discomfort.
The link between estrogen and libido 
Low estrogen affects more than the skin and muscles in the vaginal area. It also changes how the brain processes sexual desire. In some cases, low estrogen levels and libido are closely tied.
Boosting local estrogen may help by:
- Increasing blood flow and sensation in vaginal tissue
- Reducing pain or discomfort during sex
- Making arousal easier to achieve
- Encouraging the body to respond more normally to sexual activity.
Other hormones that play a role
Sex drive also involves testosterone and menopause. Though it’s often thought of as a male hormone, women’s bodies also make small amounts of testosterone. These levels can drop after menopause, leading to:
- Lower sexual interest
- Fewer sexual thoughts or fantasies
- Reduced responsiveness to touch or stimulation.
Vagifem does not contain testosterone, so its effects on libido are mostly indirect. If sexual desire remains low after treating vaginal discomfort, a doctor may suggest checking other hormone levels or considering additional treatments.
What else affects libido after menopause?
Libido isn’t just about hormones. Many women going through menopause also deal with:
- Sleep problems
- Body image concerns
- Fatigue
- Anxiety or depression.
All of these are part of the broader psychological effects of menopause. When a person feels stressed or disconnected from their body, it can be harder to feel desire. Menopause coping strategies may include:
- Regular exercise
- Open communication with a partner
- Using vaginal moisturizers or nonhormonal lubricants
- Trying natural remedies for menopause symptom relief like mindfulness, yoga, or herbal supplements (under guidance).
When to expect results from Vagifem

Changes in sex drive and libido may happen once:
- Pain during sex goes away
- The vaginal area feels more like it used to
- The body begins responding more naturally during intimacy.
If a person still experiences low desire after three months of treatment, it may help to speak with a doctor about other possible causes.
Summary
Vagifem supports sexual health after menopause by relieving the physical discomforts caused by low estrogen. While it doesn’t directly increase libido, it helps remove common barriers to sexual enjoyment. With less dryness, irritation, and pain, it becomes easier to feel comfortable and confident. Combined with other menopause coping strategies, Vagifem can play a helpful role in improving sexual well-being.
Frequently asked questions
Does estrogen give you a high sex drive?
Estrogen helps the body respond to sexual touch and stimulation. It increases blood flow, improves lubrication, and makes tissues more sensitive. When estrogen is low, like during or after menopause, sex can feel uncomfortable or even painful. Raising estrogen doesn’t act like an aphrodisiac, but it may help bring the sex drive and libido back to a state where desire can return naturally. For some women, this leads to an increase in sex drive, though the effect is different for everyone.
Can Vagifem cause weight gain?
Vagifem delivers a very small amount of estrogen directly to the vaginal tissue. It doesn’t have much effect on the rest of the body, so it’s not likely to cause weight gain. Some women may gain weight during menopause for other reasons, such as changes in metabolism or lower activity levels. Vagifem itself isn’t known to affect appetite or body fat.
How long can a person stay on Vagifem?
There’s no strict time limit for using Vagifem. Some women use it for a few months to relieve symptoms, while others continue longer-term. Because Vagifem is a low-dose local therapy, it’s considered safer than other forms of hormone replacement. A doctor may recommend using it regularly for as long as symptoms remain bothersome. It’s usually checked every 6 to 12 months to be sure it’s still helpful.
Does estrogen make sex feel better?
Estrogen helps the body respond to sex more comfortably. It improves lubrication, reduces pain, and increases sensitivity in vaginal tissue. These changes can make sex feel more enjoyable. When sex is no longer painful or irritating, a person may be more open to intimacy. Estrogen doesn’t increase sexual desire directly, but it helps make sex physically easier and more pleasurable.
What menopause symptoms does estradiol help with?
Estradiol is a form of estrogen used to treat many postmenopausal symptoms. It helps with:
- Vaginal dryness, burning, and irritation
- Pain during sex
- Vaginal thinning (atrophy)
- Mild urinary problems like urgency or burning.
Estradiol can be delivered through creams, tablets (like Vagifem), or patches. Vagifem focuses mainly on vaginal symptoms and is not used for hot flashes or mood changes, but has a direct effect on sex drive and libido.






