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For visual reference only; actual product may vary
US Name:
Darvacet
Alternative Names:
Algolysin forte
Active Ingredients:
Dextropropoxyphene
Brand Manufacturer:
Manufacturer Location:
Israel
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For visual reference only; actual product may vary
Darvacet was a prescription opioid analgesic containing dextropropoxyphene, used for mild to moderate pain. It was withdrawn from the U.S. market by the FDA in 2010 due to serious safety risks, including potentially fatal heart rhythm abnormalities, and is no longer available.
This product is not currently available
Darvacet was a prescription medication used to relieve mild to moderate pain. It contained the active ingredient dextropropoxyphene, which is an opioid analgesic. The drug was available in tablet form and was often prescribed when other non-opioid pain relievers were not effective. However, due to significant safety concerns, Darvacet and all other dextropropoxyphene-containing products were removed from the market in the United States and are no longer available for prescription.
Darvacet worked by acting on the central nervous system (CNS) to decrease the perception of pain. As an opioid, dextropropoxyphene binds to specific receptors in the brain and spinal cord, which blocks pain signals from being sent throughout the body. This action changes how your body feels and responds to pain. While effective for some, its mechanism also carried significant risks, particularly its effect on the heart’s electrical activity, which ultimately led to its discontinuation.
Darvacet was intended for adults suffering from mild to moderate pain that was not adequately managed by other pain medications like acetaminophen or NSAIDs. It was used for both short-term (acute) pain following an injury or surgery and for some long-term (chronic) pain conditions. Doctors prescribed it cautiously, and it was not suitable for everyone, especially patients with a history of heart conditions, liver problems, or substance abuse issues.
The dosage of Darvacet was determined by a doctor based on the patient’s condition and response to treatment. Typically, it was taken every 4 to 6 hours as needed for pain. It was crucial for patients to take the medication exactly as prescribed and not to exceed the recommended dose. Taking more than prescribed, or taking it with alcohol or other central nervous system depressants, greatly increased the risk of serious side effects, including fatal overdose and the severe heart complications that led to its market removal.
The side effects of Darvacet ranged from common to severe. Commonly, patients experienced dizziness, sedation, nausea, and vomiting. However, the most critical risk, which led to its FDA ban, was its potential to cause serious and fatal heart rhythm abnormalities. Studies showed that even at therapeutic doses, dextropropoxyphene could interfere with the heart’s electrical activity, leading to potentially deadly arrhythmias. The risk of overdose was also high, particularly when mixed with alcohol or other sedatives.
While Darvacet is no longer available, your need for effective pain management remains. At IsraelPharm, we provide access to a wide range of currently approved, safer, and effective medications for pain and inflammation. Our platform offers detailed, medically reviewed information to help you and your doctor make informed decisions about your health. You can explore modern alternatives and learn about their uses, benefits, and side effect profiles, ensuring you find a treatment that is both effective and appropriate for your specific health needs.
Common Side Effects:
Serious Side Effects (Leading to Market Withdrawal):
Darvacet was previously indicated for the following purpose:
Darvacet was removed from the market in 2010 by the FDA due to significant safety risks. New data revealed that its active ingredient, dextropropoxyphene, could cause serious and potentially fatal heart rhythm abnormalities, even when taken at the recommended dosage. The agency concluded that the drug's risks to cardiovascular health outweighed its limited pain relief benefits, leading to its complete withdrawal to protect public health.
Darvacet was a prescription opioid analgesic prescribed for the relief of mild to moderate pain. It was typically used when over-the-counter pain relievers like ibuprofen or acetaminophen were not sufficient to manage a patient's pain. It was used for both acute pain, such as after an injury, and some chronic pain conditions. However, it is no longer considered a safe treatment option.
Darvacet was classified as an opioid analgesic for mild to moderate pain, making it less potent than strong opioids like morphine or oxycodone. However, it was still a controlled substance with risks of dependence and abuse. Its primary danger, which led to its discontinuation, was not its strength but its specific toxicity to the heart's electrical system, a risk not commonly associated with other opioids.
Common side effects included dizziness, drowsiness, nausea, vomiting, and constipation. The most dangerous side effect, and the reason for its ban, was its impact on the heart. It could alter the heart's electrical rhythm, a condition known as QT prolongation, potentially leading to a life-threatening arrhythmia. This risk was present even at normal therapeutic doses.
The active ingredient in Darvacet was dextropropoxyphene. It is an opioid pain reliever that works on the central nervous system to block pain signals. It was this specific substance that was found to have dangerous effects on heart rhythms, prompting the FDA to remove all medications containing it from the United States market.
No, you cannot get a prescription for Darvacet or any product containing dextropropoxyphene in the United States. It was officially withdrawn from the market by the FDA in November 2010. Any website claiming to sell Darvacet is operating illegally and likely offering counterfeit or unsafe products. It is important to consult a doctor for a safe, approved alternative.
Safe alternatives for mild to moderate pain include non-opioid options like ibuprofen (Advil), naproxen (Aleve), and acetaminophen (Tylenol). For pain that requires a stronger approach, a doctor might prescribe other, currently approved opioid medications or non-opioid drugs like gabapentin or certain antidepressants. The best alternative depends on your specific type of pain and health profile.
Yes, as an opioid, Darvacet had the potential for psychological and physical dependence, especially with long-term use. The risk of addiction was a significant concern, as with all opioid medications. Patients taking it could develop a tolerance, requiring higher doses for the same effect, and experience withdrawal symptoms if they stopped taking it abruptly.
No, it was strongly advised not to drink alcohol while taking Darvacet. Both alcohol and dextropropoxyphene act as central nervous system depressants. Combining them could lead to enhanced drowsiness, dizziness, and impaired coordination. More dangerously, this combination significantly increased the risk of respiratory depression (slowed breathing) and fatal overdose.
Darvacet's active ingredient, dextropropoxyphene, was found to interfere with the heart's electrical system. It could block ion channels responsible for maintaining a normal heartbeat, leading to a condition called QT interval prolongation. This delay in the heart's electrical recharging process could trigger a dangerous and potentially fatal type of irregular heartbeat, or arrhythmia.
If you have old Darvacet pills, you should not take them. They are expired and were removed from the market for being unsafe. You should dispose of them properly and safely. The FDA recommends following local guidelines for prescription drug disposal, which may include take-back programs at pharmacies or police stations to prevent misuse or accidental ingestion.
Darvacet and Darvon were similar but not identical. Both contained the opioid dextropropoxyphene. Darvon contained only dextropropoxyphene, while Darvacet was a combination product that contained both dextropropoxyphene and acetaminophen (the active ingredient in Tylenol). Both drugs, along with all other dextropropoxyphene products, were banned by the FDA at the same time for the same heart-related safety risks.
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