Who is Climara intended for?

Climara is intended for women who need systemic estrogen therapy due to menopausal symptoms such as hot flashes or vaginal atrophy, or for women with low estrogen caused by ovarian failure, surgical removal of the ovaries, or certain medical conditions. It can also be used to help prevent post-menopausal bone loss in women who are not candidates for non-estrogen therapy. It is not for women who are pregnant or breastfeeding. Women with an intact uterus typically require an added progestin to reduce the risk of endometrial thickening when using systemic estrogen.

How is the Climara patch applied?

Climara is applied once a week to a clean, dry, non-irritated area of skin on the lower abdomen or buttocks. The patch should be pressed firmly in place for several seconds to secure full contact. It should not be applied to the breasts. Application sites should be rotated weekly to help prevent skin irritation. Clothing that rubs tightly against the patch should be avoided. Once applied, the patch delivers a controlled amount of estradiol through the skin for seven days before it is replaced with a new patch on the same weekday each week.

What should be done if a patch falls off?

If the patch becomes loose, it may be pressed back into place. If it falls off completely and cannot be reapplied, a new patch can be used. This replacement patch should stay in place until the next regularly scheduled patch change. The dosing schedule does not change. Only one patch should be worn at a time. A patch should not be replaced early in an attempt to “catch up.” Avoid applying two patches at once. If patches detach repeatedly, the application site may need to be changed or cleaned more carefully before use.

How long should treatment with Climara continue?

Treatment duration depends on symptoms and the woman’s overall health plan. Healthcare providers generally recommend using the lowest effective dose for the shortest duration needed to achieve symptom control. Women using Climara should have periodic evaluations to determine whether continuing therapy is still needed. Decisions may be based on menopausal symptoms, bone-health goals, and individual risk factors. Some women may need a short treatment period for hot flashes, while others with early menopause may need longer support. Regular reviews help ensure that benefits continue to outweigh potential risks over time.

Does Climara affect bone health?

Estrogen plays a significant role in maintaining bone density. When estrogen declines after menopause, bones may lose strength more quickly. Climara can help slow bone loss in women who are at risk of osteoporosis and who cannot use non-estrogen options. It helps maintain bone mineral density by restoring estrogen levels to support bone-forming cells and reduce the rate of bone breakdown. However, it is not suitable for every woman, and lifestyle factors such as exercise, calcium intake, and vitamin D remain important. Climara is used when systemic estrogen therapy is considered appropriate.

Can Climara be used by women with an intact uterus?

Climara contains only estrogen. Women who still have a uterus usually require a progestin in addition to systemic estrogen therapy. This is because estrogen alone may cause thickening of the uterine lining, which can increase the risk of endometrial problems. A healthcare provider determines which form of progestin is appropriate, how often it should be used, and whether combination therapy is needed continuously or on a cyclical schedule. Climara can be safely used in women with a uterus only when the required progestin protection is included as part of the treatment plan.

Can Climara be used for vaginal dryness?

Yes. Climara may help with moderate to severe vaginal dryness when this condition is part of post-menopausal estrogen deficiency. Because the patch releases systemic estrogen, it can improve the tissues of the vagina and vulva over time. However, some women may benefit from local estrogen treatments instead, particularly when vaginal symptoms occur without other systemic menopausal symptoms. A healthcare provider will determine whether systemic therapy, local therapy, or a combination is most appropriate. Climara can be part of a treatment plan when broader estrogen support is needed.

What should women discuss with their healthcare provider before starting Climara?

Before beginning therapy, women should share their full medical history, including past clotting events, heart disease, stroke, cancer, liver conditions, and any unexplained vaginal bleeding. A discussion should also include current medications, timing of menopause, presence of a uterus, and overall treatment goals. Bone-health status, lifestyle factors, and personal risk tolerance also help determine if Climara is the right choice. Regular follow-ups allow the healthcare provider to reassess dose, monitor symptoms, and ensure that benefits continue to outweigh risks. These conversations support safe and effective use of systemic estrogen therapy.

Spend $99, get free U.S. shipping*

Tariff now required on U.S. shipments. Learn more »

Tel: 1-866-456-3768 Fax: 1-866-544-8993

Home / Online Pharmacy / Climara

For visual reference only; actual product may vary

US Name:

Climara
Alternative Names:

Climara, Climara Forte
Active Ingredients:

Estradiol
Brand Manufacturer:

Bayer
Manufacturer Location:
Click here to view Product Insert
Click here to view Product Insert
Click here to view Product Insert

Climara ^*

For visual reference only; actual product may vary

Prescription Required

All third-party products, company names, and logos are trademarks™ or registered® trademarks are and remain the property of their respective holders. Their use does not imply any affiliation with or endorsement by them. All references on this site to third-party trademarks are intended to constitute nominative fair use under applicable trademark laws.

Climara is used for conditions related to estrogen deficiency usually following the onset of menopause.

Place your order

Climara Brand	50mcg 4 Patches	- Climara – Brand, Climara, 50mcg, 4, Patches, 888888, Bayer, 2594 + 0	Our price: $52.00
Climara Brand	25mcg 4 Patches	- Climara – Brand, Climara, 25mcg, 4, Patches, 888888, Bayer, 2593 + 0	Our price: $50.00
Climara Forte Brand	7.8mg 4 Patches	- Climara – Brand, Climara Forte, 7.8mg, 4, Patches, 99999, Bayer, 2122 + 0	Our price: $91.00

Saul Recommends

Her Essentials Pack	30 Pouches 1 Pouch a Day	– Her Essentials Pack + 1	Our price: $68.85
Women's Hormone Support Pack	30 Pouches 1 Pouch a Day	– Women's Hormone Support Pack + 1	Our price: $58.65

*Please note all prices are in US dollars

Description
Side Effects
Indications
FAQ
Video

Climara (estradiol) is a prescription medicine used to relieve symptoms associated with menopause. The medication is a form of hormone replacement therapy (HRT) and belongs to the drug class known as estrogens. It is manufactured as a transdermal patch that is designed to be applied to the skin once every seven days. This design offers a continuous and consistent release of the active ingredient into the bloodstream over the course of the week.

Estradiol is a type of estrogen. It is chemically identical to the primary form of estrogen naturally produced by a woman’s ovaries before menopause. During menopause, the ovaries gradually stop making adequate levels of estrogen, and this natural reduction in hormones can lead to various uncomfortable symptoms. Estradiol works by simply replacing the estrogen that the body no longer produces in sufficient quantities.

By increasing the levels of this vital hormone, Climara helps to regulate and stabilize the body’s overall hormonal balance. This mechanism allows the patch to effectively treat various moderate to severe symptoms experienced by women in menopause, such as the sudden, intense feelings of body heat and sweating known as hot flashes. The transdermal delivery system is considered an effective method because it delivers the hormone directly through the skin and bypasses the digestive system and the initial metabolism by the liver. This leads to a steady and sustained level of the hormone in the circulation for the entire week the patch is worn.

Dosage

Climara is a transdermal system, meaning it is a patch applied to the skin. It is used once weekly, with the patient replacing the old patch with a new one on the same day each week to maintain the dosing schedule. Therapy is typically started with the lowest dose, which is 0.025 milligrams (mg) per day, delivered through the skin. The doctor may adjust this dosage based on how well the patient’s symptoms are controlled.

The patch should be applied to a smooth, clean, dry, and hairless area of the skin on the lower abdomen or the upper quadrant of the buttock. It is important that the patch is not applied to or near the breasts. The application site must be rotated, with at least a 1-week interval allowed between applications to the same spot.

The patch must be pressed firmly onto the skin for at least 10 seconds to ensure good contact, especially around the edges. If a patch falls off, the patient should try to reapply it. If it cannot be reapplied, a new patch should be put on a different area, but only worn for the remainder of the scheduled 7-day period. Patients should not change their patch removal schedule or wear more than one patch at a time.

Storage

The proper storage of Climara is essential to ensure the medication remains effective. The patches should be stored at room temperature, which is defined as between 68-77°F (20-25°C). They must not be stored in areas where the temperature could rise above 86°F (30°C). It is important to keep the patches away from excess heat, moisture, and direct light.

The patches must remain sealed in their protective foil pouches until the moment they are applied. They should not be removed from the pouch or stored unpouched beforehand, as this can affect the patch’s ability to stick and deliver the medicine.

Climara should be stored securely and kept out of the reach of children and pets. Used patches still contain active hormones, so disposal must be done carefully to prevent accidental exposure. To throw away a used patch, the sticky sides should be folded together so the patch sticks to itself. The folded patch should then be placed in a sturdy, child-proof container and discarded in the trash. Used patches should never be flushed down the toilet.

This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication.

The patient information leaflet that comes with the medication includes full information about the correct usage, storage and possible side effects. Be sure to read and understand these, and if there are any questions, discuss these with a healthcare provider or pharmacist before starting treatment.

Most people who use Climara do not experience any adverse side effects. Doctors prescribe this medication because they assess the benefits of such treatment outweigh any likely unwanted effects.

Common side effects:

skin irritation at the patch site
headache
breast tenderness
abdominal discomfort
mild nausea
fluid retention
vaginal spotting or bleeding

Serious side effects requiring immediate action:

sudden chest pain or shortness of breath
severe headache or vision changes
swelling, warmth, or pain in one leg
sudden vaginal bleeding

These may indicate rare but serious risks such as clotting events or stroke. Get immediate attention from a doctor or call 911 if you cannot get to an emergency healthcare center.

Not all side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.

Climara is used for conditions related to estrogen deficiency, including:

Vasomotor symptoms of menopause

Typical symptoms include:

sudden hot flashes
night sweats
sleep disturbances
mood changes
These symptoms occur when decreased estrogen affects temperature regulation.

Vulvar and vaginal atrophy due to menopause

Symptoms may include:

vaginal dryness
itching or irritation
pain with intercourse
urinary discomfort
These occur as estrogen levels drop and tissues become thinner and less flexible.

Hypoestrogenism from hypogonadism, castration, or ovarian failure

Women with very low estrogen may experience:

hot flashes
thinning vaginal tissues
reduced bone density
fatigue or low mood

Prevention of post-menopausal osteoporosis

Climara helps reduce bone loss in women at significant fracture risk who require estrogen therapy and cannot use other treatments. It maintains bone mineral density by replacing missing estrogen.

Climara is intended for women who need systemic estrogen therapy due to menopausal symptoms such as hot flashes or vaginal atrophy, or for women with low estrogen caused by ovarian failure, surgical removal of the ovaries, or certain medical conditions. It can also be used to help prevent post-menopausal bone loss in women who are not candidates for non-estrogen therapy. It is not for women who are pregnant or breastfeeding. Women with an intact uterus typically require an added progestin to reduce the risk of endometrial thickening when using systemic estrogen.
Climara is applied once a week to a clean, dry, non-irritated area of skin on the lower abdomen or buttocks. The patch should be pressed firmly in place for several seconds to secure full contact. It should not be applied to the breasts. Application sites should be rotated weekly to help prevent skin irritation. Clothing that rubs tightly against the patch should be avoided. Once applied, the patch delivers a controlled amount of estradiol through the skin for seven days before it is replaced with a new patch on the same weekday each week.
If the patch becomes loose, it may be pressed back into place. If it falls off completely and cannot be reapplied, a new patch can be used. This replacement patch should stay in place until the next regularly scheduled patch change. The dosing schedule does not change. Only one patch should be worn at a time. A patch should not be replaced early in an attempt to “catch up.” Avoid applying two patches at once. If patches detach repeatedly, the application site may need to be changed or cleaned more carefully before use.
Treatment duration depends on symptoms and the woman’s overall health plan. Healthcare providers generally recommend using the lowest effective dose for the shortest duration needed to achieve symptom control. Women using Climara should have periodic evaluations to determine whether continuing therapy is still needed. Decisions may be based on menopausal symptoms, bone-health goals, and individual risk factors. Some women may need a short treatment period for hot flashes, while others with early menopause may need longer support. Regular reviews help ensure that benefits continue to outweigh potential risks over time.
Estrogen plays a significant role in maintaining bone density. When estrogen declines after menopause, bones may lose strength more quickly. Climara can help slow bone loss in women who are at risk of osteoporosis and who cannot use non-estrogen options. It helps maintain bone mineral density by restoring estrogen levels to support bone-forming cells and reduce the rate of bone breakdown. However, it is not suitable for every woman, and lifestyle factors such as exercise, calcium intake, and vitamin D remain important. Climara is used when systemic estrogen therapy is considered appropriate.
Climara contains only estrogen. Women who still have a uterus usually require a progestin in addition to systemic estrogen therapy. This is because estrogen alone may cause thickening of the uterine lining, which can increase the risk of endometrial problems. A healthcare provider determines which form of progestin is appropriate, how often it should be used, and whether combination therapy is needed continuously or on a cyclical schedule. Climara can be safely used in women with a uterus only when the required progestin protection is included as part of the treatment plan.
Yes. Climara may help with moderate to severe vaginal dryness when this condition is part of post-menopausal estrogen deficiency. Because the patch releases systemic estrogen, it can improve the tissues of the vagina and vulva over time. However, some women may benefit from local estrogen treatments instead, particularly when vaginal symptoms occur without other systemic menopausal symptoms. A healthcare provider will determine whether systemic therapy, local therapy, or a combination is most appropriate. Climara can be part of a treatment plan when broader estrogen support is needed.
Before beginning therapy, women should share their full medical history, including past clotting events, heart disease, stroke, cancer, liver conditions, and any unexplained vaginal bleeding. A discussion should also include current medications, timing of menopause, presence of a uterus, and overall treatment goals. Bone-health status, lifestyle factors, and personal risk tolerance also help determine if Climara is the right choice. Regular follow-ups allow the healthcare provider to reassess dose, monitor symptoms, and ensure that benefits continue to outweigh risks. These conversations support safe and effective use of systemic estrogen therapy.

Getting started with IsraelPharm

Required

Send Your Prescription

Secure Payment

No Hidden Fees

Fast Shipping

Generally 7-10 Business Days

Ordering is
simple and safe.

IsraelPharm has been delivering lost cost prescriptions from Israel for over 15 years worldwide. Daily flights allow us to get your medications dispatched fast! Delivery to the USA is under 10 days and you can track and trace every order.

Categories

Resources