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For visual reference only; actual product may vary
For visual reference only; actual product may vary
Zymfentra (infliximab) is a self-administered injection for adults with chronic inflammatory conditions like Crohn’s disease and ulcerative colitis. It offers a convenient subcutaneous option for maintenance therapy to help control symptoms. This product requires cold shipping.
| Remsima SC Brand | 120mg 2 Pre-Filled Pens |
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Our price: $835.00 |
Zymfentra is a prescription medication used for the maintenance treatment of Crohn’s disease and ulcerative colitis in adults. As the first subcutaneous (under the skin) formulation of infliximab, it provides a new, convenient option for patients. Zymfentra is a biologic drug that belongs to a class of medications known as Tumor Necrosis Factor (TNF) inhibitors. It is designed for patients to self-administer at home after receiving proper training from a healthcare provider. This helps to continuously manage symptoms and keep the inflammatory conditions under control without regular visits to an infusion center.
Zymfentra works by blocking a specific protein in the immune system called Tumor Necrosis Factor-alpha (TNF-alpha). In people with autoimmune conditions like Crohn’s disease and ulcerative colitis, the body produces too much TNF-alpha. This overproduction leads to excessive inflammation in the gastrointestinal tract, causing symptoms like pain, diarrhea, and rectal bleeding. Zymfentra specifically targets and neutralizes TNF-alpha. By inhibiting this protein, the medication disrupts the inflammatory process, leading to reduced inflammation in the gut lining. This helps to alleviate symptoms, induce and maintain remission, and improve overall quality of life for patients.
Zymfentra is intended for adults diagnosed with moderately to severely active Crohn’s disease or ulcerative colitis. It is specifically used as a maintenance therapy to keep the conditions in remission. Typically, a patient would have first received initial doses of infliximab through an IV (intravenous) infusion. If they respond well to the initial treatment, their doctor may switch them to Zymfentra for long-term management. This medication is ideal for patients who prefer the convenience of a self-administered injection at home instead of traveling to a clinic for regular infusions. It allows for greater flexibility and control over their treatment schedule.
Zymfentra is administered as a subcutaneous injection, meaning it is injected just under the skin. The standard dosage for maintenance therapy is 120 mg given every two weeks. Before you begin self-administering, a healthcare professional must provide training on the correct injection technique. You will learn how to prepare the pre-filled syringe or auto-injector and where to inject the medication, such as the thighs or abdomen. It is very important to follow your doctor’s prescribed schedule. Do not alter the dose or stop the medication without consulting your healthcare provider, as this can affect how well the treatment works.
Zymfentra may cause side effects, which can range from mild to serious. Common side effects include upper respiratory infections, headache, abdominal pain, and reactions at the injection site like redness or swelling. More serious side effects are possible because Zymfentra affects the immune system. These can include an increased risk of serious infections, such as tuberculosis. Other serious risks include the potential for new or worsening heart failure, liver problems, and certain types of cancer. It is important to discuss all potential risks with your doctor. Seek immediate medical help if you experience signs of a severe allergic reaction, such as difficulty breathing or swelling of the face.
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Common side effects may include:
Serious side effects may include:
Zymfentra is an FDA-approved prescription medication for the maintenance treatment of adults with:
Zymfentra is the first subcutaneous (under the skin) formulation of infliximab for maintenance therapy. Other infliximab products are given through intravenous (IV) infusion in a clinical setting. This allows patients using Zymfentra to self-administer their treatment at home after proper training. This offers greater convenience compared to regular clinic visits for infusions and more stable drug levels in the body.
Zymfentra does not have a direct major interaction with moderate alcohol consumption. However, alcohol can worsen symptoms of Crohn's disease and ulcerative colitis. It may also increase the risk of liver problems, a potential concern with medications like infliximab. It is best to discuss your alcohol use with your doctor to ensure it is safe for your specific condition.
If you miss a dose of Zymfentra, you should contact your healthcare provider immediately for instructions. Do not simply take the next dose without their guidance. Your doctor will tell you when to take your missed dose and how to adjust your future dosing schedule. Staying on your prescribed schedule is important to maintain control of your condition.
Zymfentra is used for maintenance therapy after you have already responded to initial intravenous infliximab. The goal of Zymfentra is to maintain that response and prevent symptoms from returning. You should continue to feel the benefits as long as you take the medication regularly. The full effect of maintaining remission is seen over several weeks of consistent use.
Yes, Zymfentra should only be self-injected after you receive proper training from a healthcare professional. They will show you the correct technique for preparing the syringe, choosing an injection site like the thigh or abdomen, and safely administering the dose. Never attempt to use this medication on your own without being trained by a qualified provider.
Zymfentra must be stored in a refrigerator between 36°F to 46°F (2°C to 8°C). Keep it in its original carton to protect it from light. Do not freeze Zymfentra. If a dose is accidentally frozen, it must be discarded. Before injection, you may allow it to sit at room temperature for 30 minutes, but do not warm it in any other way.
Yes, Zymfentra works by suppressing a part of your immune system to reduce inflammation. This action can lower your ability to fight infections. You should tell your doctor about any signs of infection, such as fever, cough, or flu-like symptoms. Your doctor will likely test you for tuberculosis (TB) before you start treatment.
Before starting Zymfentra, your healthcare provider will want to ensure all your vaccinations are up to date. It is recommended to receive any necessary vaccines, especially live vaccines, before beginning your treatment. While taking Zymfentra, you should not receive live vaccines as they may cause a serious infection due to the medication’s effect on your immune system.
Signs of an allergic reaction to Zymfentra can include hives, difficulty breathing, or swelling of your face, lips, tongue, or throat. You might also experience fever, a new rash, headache, or muscle pain. Seek immediate medical attention if you experience any symptoms of a severe allergic reaction, as these can be life-threatening.
You must tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding before starting Zymfentra. The medication can be passed to a baby during pregnancy and may be present in breast milk. Your doctor will help you weigh the potential benefits of the treatment against the potential risks to your baby.
Zymfentra is a TNF inhibitor, which stands for Tumor Necrosis Factor inhibitor. TNF-alpha is a protein in your body that causes inflammation. In conditions like Crohn's and ulcerative colitis, excess TNF-alpha leads to chronic inflammation in the gut. Zymfentra works by specifically targeting and blocking this protein, which helps to reduce inflammation and control your symptoms effectively.
Zymfentra does not cure Crohn's disease or ulcerative colitis, as there is currently no known cure for these conditions. It is a long-term maintenance treatment designed to help manage your symptoms, reduce inflammation, and keep the disease in remission. Consistent use as prescribed can significantly improve your quality of life by preventing symptom flare-ups.
Zymfentra itself does not require you to avoid any specific foods. However, since it is a treatment for Crohn's and ulcerative colitis, you should continue to follow any dietary guidelines from your doctor. Certain foods can trigger your gastrointestinal symptoms, and managing your diet is a key part of managing your overall condition while on this medication.
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