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Home / Online Pharmacy / Twynsta

For visual reference only; actual product may vary

US Name:

Twynsta
Alternative Names:

Twynsta
Active Ingredients:

Telmisartan - Amlodipine Besylate
Brand Manufacturer:

Boehringer
Manufacturer Location:

Canada
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Twynsta ^*

For visual reference only; actual product may vary

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Twynsta is prescribed for high blood pressure (hypertension) combining two active ingredients (ARB and CCB).

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Twynsta Brand	80/10mg 28 Tablets	- Twynsta – Brand, Twynsta, 80/10mg, 28, Tablets, 888888, Boehringer, 2625 + 0	Our price: $53.00
Twynsta Brand	80/5mg 28 Tablets	- Twynsta – Brand, Twynsta, 80/5mg, 28, Tablets, 888888, Boehringer, 2624 + 0	Our price: $53.00
Twynsta Brand	40/10mg 28 Tablets	- Twynsta – Brand, Twynsta, 40/10mg, 28, Tablets, 888888, Boehringer, 2623 + 0	Our price: $53.00
Twynsta Brand	40/5mg 28 Tablets	- Twynsta – Brand, Twynsta, 40/5mg, 28, Tablets, 888888, Boehringer, 2622 + 0	Our price: $53.00

*Please note all prices are in US dollars

Description
Side Effects
Indications
FAQ
Video

Twynsta (generic name: telmisartan and amlodipine) is a prescription medication for high blood pressure (hypertension). By combining two active ingredients, it offers a dual approach to lowering blood pressure, which can help reduce the risk of cardiovascular events such as heart attacks and strokes. Twynsta combines telmisartan, an angiotensin II receptor blocker (ARB), and amlodipine, a calcium channel blocker (CCB). Telmisartan works by blocking the action of angiotensin II, a substance in the body that causes blood vessels to constrict. By inhibiting this action, telmisartan helps blood vessels relax and widen, leading to lower blood pressure. Amlodipine complements this effect by preventing calcium from entering the muscle cells of the heart and blood vessels, which also results in vessel relaxation and improved blood flow. Twynsta is primarily prescribed for the treatment of hypertension, either as a standalone therapy or in combination with other antihypertensive agents. It’s particularly beneficial for patients who require multiple medications to achieve their blood pressure targets. By effectively lowering blood pressure, Twynsta contributes to reducing the risk of cardiovascular complications associated with hypertension. The dual-action mechanism of Twynsta addresses blood pressure regulation through two distinct pathways:

Telmisartan (ARB): By blocking angiotensin II receptors, telmisartan prevents the vasoconstrictive effects of angiotensin II, leading to vasodilation and decreased blood pressure.
Amlodipine (CCB): Amlodipine inhibits the influx of calcium ions into vascular smooth muscle cells and cardiac muscle cells. This inhibition causes relaxation of the vascular smooth muscles, resulting in lowered peripheral resistance and reduced blood pressure.

Combining these two agents into a single tablet simplifies the treatment regimen, which can enhance patient adherence to therapy. Effective management of hypertension with Twynsta can lead to a significant reduction in the risk of cardiovascular events, thereby improving overall health outcomes. For more detailed information on hypertension and its management, visit the American Heart Association’s website.

Dosage and administration

Twynsta is available in tablet form with varying strengths of telmisartan and amlodipine. The typical starting dose is one tablet taken once daily, with or without food. The specific dosage may vary depending on individual patient factors, including the severity of hypertension and response to treatment. It’s important to take Twynsta consistently at roughly the same time each day to maintain its blood pressure-lowering effect. If a dose is missed, it should be taken as soon as remembered. However, if it’s almost time for the next scheduled dose, the missed dose should be skipped. Do not doble-dose to make up for a missed dose. Patients should not adjust their dosage without consulting their healthcare provider.

Storage

Twynsta tablets should be stored at room temperature, between 68-77°F (20-25°C). They should be kept in their original packaging, away from moisture and light.

Caution

Twynsta carries a boxed warning regarding fetal toxicity. Women who could become pregnant should use adequate birth control while taking the drug. It should be discontinued as soon as pregnancy is detected due to the risk of injury and death to the developing fetus. Nursing mothers should consult with a doctor to decide whether to discontinue the drug or stop breastfeeding, considering the importance of the medication to the mother.

Common Questions About Twynsta

How long does it take for telmisartan and amlodipine to lower blood pressure?

The antihypertensive effects of telmisartan and amlodipine are typically observed within two weeks of starting treatment, with maximum blood pressure reduction occurring after approximately four weeks. Individual responses may vary, and it’s important to continue taking the medication as prescribed, even if no immediate changes are noticed.

Can telmisartan and amlodipine cause kidney problems?

In certain individuals, particularly those with pre-existing kidney conditions or those taking other medications affecting kidney function, telmisartan and amlodipine may impact renal function. Regular monitoring of kidney function through blood tests is recommended during treatment. Any significant changes in urination patterns or swelling should be reported to a healthcare provider promptly.

What lifestyle changes can help manage hypertension?

In addition to medication, lifestyle modifications can significantly impact blood pressure control. These include adopting a balanced diet rich in fruits, vegetables, and whole grains; reducing sodium intake; engaging in regular physical activity; maintaining a healthy weight; limiting alcohol consumption; and managing stress.

This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication.

Read the information leaflet that comes with the medication.

If a sudden allergic reaction (anaphylaxis) occurs after taking Twynsta , with symptoms like swelling of the face, tongue, or throat making it difficult to breathe or swallow, or there is wheezing, hives, rash, blistering, or peeling of the skin, call a doctor or 911 right away, or go to an emergency room immediately.

Most people who use Twynsta do not experience any adverse side effects. Doctors prescribe this medication because they assess the benefits of such treatment outweigh any likely unwanted effects.

Some of the side effects that have been reported may include peripheral edema (swelling of the legs or ankles), dizziness, and back pain. While these are generally mild, patients should monitor their symptoms and consult their healthcare provider if they become bothersome.

Not all side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.

Twynsta is approved for the treatment of hypertension (high blood pressure). Hypertension is a condition where the force of the blood against the artery walls is consistently too high, which can lead to health problems such as heart disease and stroke. Symptoms of hypertension are often not noticeable, which is why it’s frequently referred to as a “silent killer.” In some cases, individuals may experience headaches, shortness of breath, or nosebleeds, but these symptoms aren’t specific and usually don’t occur until hypertension has reached a severe or life-threatening stage. By effectively lowering blood pressure, Twynsta helps reduce the risk of associated complications.

Both ACE inhibitors and ARBs work by blocking the action of angiotensin-2 (also known as AT2) in the body. AT2 is a hormone produced by the body that helps to regulate blood pressure. If blood pressure is low, the body produces AT2 to increase it. The main mechanism of action of AT2 is vasoconstriction, especially in the kidneys. If there is too much AT2, blood vessels fail to relax. This can lead to high blood pressure and or kidney failure. It also worsens heart failure and other forms of CVD. The two medicine categories work by reducing the effects of AT2 in different ways: ACE inhibitors – reduce the production of AT2 by the body. ARBs – block the receptors that AT2 uses to cause vasoconstriction. Although the two drugs act differently, they produce the same result of relaxing blood vessels and easing the pressure on the rest of the body.
Yes, ARBs and CCBs can be used in combination to manage hypertension, as they work through different mechanisms to lower blood pressure. This combination can be particularly effective in individuals whose blood pressure is not adequately controlled with a single medication. However, combining these medications should be under the guidance of a healthcare provider to monitor efficacy and potential side effects

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