Spend $99, get free U.S. shipping*
Tariff now required on U.S. shipments. Learn more »
Tel: 1-866-456-3768 Fax: 1-866-544-8993
For visual reference only; actual product may vary
For visual reference only; actual product may vary
Symproic (naldemedine) is a prescription medication designed to treat opioid-induced constipation (OIC) in adults with chronic pain. It works by blocking opioids’ effects in the gut to restore bowel function without reducing pain relief. Symproic offers a targeted approach to managing difficult OIC symptoms for improved comfort and quality of life.
Symproic is a prescription medicine specifically developed to treat opioid-induced constipation (OIC) in adult patients. This condition is a common and uncomfortable side effect for individuals taking opioid medications for chronic non-cancer pain. Symproic works by targeting the underlying cause of OIC in the gastrointestinal tract. Unlike traditional laxatives, it provides a focused treatment. It helps restore normal bowel function. Many patients experience relief from constipation symptoms while continuing their necessary pain management regimen. This medication offers a way to manage pain effectively without the disruptive side effect of constipation, improving overall well-being.
Symproic works by selectively blocking the effects of opioid pain medicines in the gut. Its active ingredient, naldemedine, is a peripherally acting mu-opioid receptor antagonist (PAMORA). This means it attaches to opioid receptors in the digestive system. By doing so, it counteracts the constipating effects of opioids, such as reduced fluid secretion and slower gut movement. Importantly, naldemedine is designed to have limited ability to cross the blood-brain barrier. This prevents it from interfering with the pain-relieving effects of the opioid medication on the central nervous system. The result is relief from constipation without compromising pain control.
Symproic is intended for adults who are experiencing constipation as a direct result of taking opioid medications for chronic pain that is not caused by cancer. This medication is suitable for patients whose OIC has not been adequately resolved by standard laxative treatments. If you are on a stable dose of opioid therapy and struggle with infrequent or difficult bowel movements, Symproic may be an appropriate option. It is prescribed for those who need to continue their opioid pain management but require targeted relief from its gastrointestinal side effects. A doctor can determine if Symproic is the right choice based on your medical history and current condition.
Symproic is typically administered as a once-daily oral tablet. The standard recommended dose should be determined by your healthcare provider. You can take Symproic with or without food at any time of day that is convenient for you. However, it is best to take it at the same time each day to maintain consistent levels in your body. If you are taking laxatives, your doctor may advise you to stop using them when you begin treatment with Symproic. Always follow your doctor’s instructions regarding dosage. Do not change your dose without consulting them first. If you have trouble swallowing, the tablet may be crushed and mixed with water.
Symproic may cause side effects in some individuals, though many people experience none. The most common side effects are related to the digestive system. These can include abdominal pain, diarrhea, nausea, and vomiting. Most of these symptoms are mild to moderate and may lessen over time. More serious side effects can occur, although they are rare. These include symptoms of opioid withdrawal like sweating, chills, or anxiety. There is also a risk of a tear in the stomach or intestinal wall (gastrointestinal perforation). Contact your doctor immediately if you experience severe stomach pain that does not go away, fever, or chills.
IsraelPharm is your trusted source for authentic and affordable medications like Symproic. We are committed to providing a secure and convenient online pharmacy experience. Our licensed pharmacists ensure every prescription is handled with care. Patients who order from us benefit from significant savings on brand-name drugs sourced from regulated distributors. We provide fast, reliable shipping directly to your door. Our customer service team is always available to assist with your needs. Choose IsraelPharm for a seamless process, competitive pricing, and the high-quality medication you depend on for your health and comfort.
Common side effects may include:
Seek immediate medical attention if you experience severe side effects, such as:
Symproic (naldemedine) is indicated for the treatment of:
Send Your Prescription
No Hidden Fees
Generally 7-10 Business Days
IsraelPharm has been delivering lost cost prescriptions from Israel for over 15 years worldwide. Daily flights allow us to get your medications dispatched fast! Delivery to the USA is under 10 days and you can track and trace every order.
Struggling with acid reflux? Sarah Ryan shares her personal experience using Nexium for GERD and how to find affordable brand-name relief through a licensed pharmacy.
Polycystic Metabolic Ovarian Syndrome (PMOS) is the new clinical name for the condition long known as Polycystic Ovary Syndrome (PCOS). The change reflects a deeper scientific understanding that insulin resistance and metabolic dysfunction sit at
