Sinequan ^*

Sinequan / Gilex (generic name: doxepin) is prescribed to treat mental health conditions such as depression and anxiety, and also certain types of chronic sleep problems.

Doxepin belongs to a group of drugs called tricyclic antidepressants, which are known for their ability to help improve mood, reduce nervousness, and assist with sleep regulation. Doxepin affects how certain natural chemicals, such as serotonin and norepinephrine, work in the brain, helping to restore emotional balance and reduce symptoms of distress.

In people with depression, Gilex is used to help lift mood, reduce feelings of sadness or hopelessness, and increase interest in daily activities. It is often prescribed when symptoms are moderate to severe or when other treatments have been ineffective. It can also be helpful for those who experience both depression and anxiety at the same time, offering relief from both emotional and physical symptoms like restlessness or racing thoughts.

For individuals dealing with anxiety disorders, doxepin may help by easing constant worry, tension, or feelings of fear. It can support mental calmness and improve sleep quality, which is often affected by anxiety. When taken as part of a long-term treatment plan, it may reduce the frequency and intensity of anxious episodes.

Sinequan is also used in some cases to help with chronic sleep maintenance problems, which involve waking up frequently during the night or having trouble staying asleep. It works by blocking the action of histamine, a natural substance in the brain that promotes wakefulness. This effect makes doxepin especially useful for improving the quality and length of sleep in those who struggle with interrupted sleep patterns.

In addition to its main uses, doxepin has prescribed off-label for conditions like skin itching caused by chronic hives or nerve-related discomfort, although these uses are less common. The medicine is part of a broader treatment plan that may include talk therapy, lifestyle changes, or other medications.

Dosage

It is essetial to follow the dosage instructions printed on the label of the box.

Doxepin doses vary depending on the condition treated and doctors often start seniors on lower doses due to sensitivity:

• For depression or anxiety, the typical starting dose is 75 mg per day, usually split into three doses (e.g., 25 mg morning, afternoon, and bedtime). The dose may increase up to 300 mg/day under medical guidance.
• For sleep maintenance, much lower doses (3 – 6 mg at bedtime) are used to help keep people asleep.

Capsules should be taken with water, at the same time each day. The contents of the capsules should not be mixed with food.

If a dose is missed, it should be taken as soon as remembered, unless the next dose is due within a few hours. In that case, the missed dose should be skipped. Never double the dose. 

Storage

Gilex capsules should be stored at room temperature (59–86°F / 15–30°C), away from moisture and direct light. Keep in the original container, tightly closed, and out of reach of children.