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For visual reference only; actual product may vary
For visual reference only; actual product may vary
Relistor (methylnaltrexone) is a prescription injection for adults with opioid-induced constipation (OIC). It specifically targets and blocks the effects of opioids in the gut. This helps restore normal bowel function without interfering with your pain management. It is often used when traditional laxatives are not effective.
| Relistor Brand | 12mg 7 Syringes |
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Our price: $479.00 |
 Gut Pack | 30 Pouches 1 Pouch a Day | –+ | Our price: $70.55 |
Relistor is a brand-name prescription medication containing the active ingredient methylnaltrexone bromide. It is designed specifically to treat a type of constipation called opioid-induced constipation (OIC) in adults. This condition is a common side effect of taking opioid medications for chronic pain. Relistor is administered as an injection just under the skin (subcutaneously). It provides relief by targeting the underlying cause of OIC without impacting the pain-relieving effects of the opioid.
Relistor works as a peripherally acting mu-opioid receptor antagonist. Opioid pain medications bind to receptors throughout the body, including in the gut. This binding slows down bowel movements, leading to hard, dry stools that are difficult to pass. Relistor selectively blocks these opioid receptors in the gastrointestinal tract. However, it does not cross the blood-brain barrier. This means it can reverse constipation without interfering with the pain relief provided by the opioid medication in the central nervous system.
Relistor is for adults who are experiencing constipation caused by long-term use of opioid medications for chronic non-cancer pain. It is a suitable treatment option when standard laxative treatments have not provided adequate relief. This medication is intended for patients who need to continue their opioid therapy for pain management but suffer from its gastrointestinal side effects. A doctor will determine if Relistor is the right choice based on a patient’s medical history and current condition. It is not intended for other types of constipation.
Relistor dosage and administration should be followed exactly as prescribed by your healthcare provider. The typical dose is an injection given under the skin of the thigh, abdomen, or upper arm. Patients are often started on a 12 mg dose administered as needed, but at least once daily. After an injection, a bowel movement can occur quickly, sometimes within 30 minutes to a few hours. For this reason, it is recommended to be near a toilet after administering the dose. Relistor comes in pre-filled syringes for ease of use. Always follow the instructions provided with the medication for proper injection technique.
Relistor may cause certain unwanted side effects, though not everyone will experience them. The most common side effects are related to the digestive system as the medication begins to work. You should discuss potential side effects with your doctor before starting treatment.
In rare cases, more serious side effects can occur. These include symptoms of opioid withdrawal or a tear in the stomach or intestinal wall (gastrointestinal perforation). Contact your doctor immediately if you experience severe stomach pain that does not go away, anxiety, or persistent diarrhea.
IsraelPharm offers a reliable and cost-effective way to get the medications you need. We are a licensed pharmacy providing authentic, brand-name drugs like Relistor sourced from regulated international distributors. Our streamlined online platform allows you to order your prescription with ease from the comfort of your home. We pride ourselves on excellent customer service, ensuring your privacy and providing support throughout the ordering process. By removing intermediaries, we offer significant savings on your essential medications without compromising on quality or safety.
Most individuals using Relistor experience minimal side effects. However, some common reactions may occur, including:
Consult your doctor if these symptoms persist or worsen. Seek immediate medical attention for severe, worsening abdominal pain, as this could signal a rare but serious condition. This is not a complete list of all possible side effects.
Relistor is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic, non-cancer related pain. This specific type of constipation occurs when opioid painkillers slow down the normal movement of the intestines, making stools hard and difficult to pass. It is used when conventional laxative therapies have not been effective.
Relistor can work very quickly to produce a bowel movement. Many patients experience relief within 30 minutes to four hours after the injection. Because the onset of action is rapid, it is strongly recommended that you remain close to toilet facilities after administering your dose to avoid any potential accidents or discomfort. The exact timing can vary between individuals.
Relistor can be administered once daily if needed, though some patients may use it less frequently. Your doctor will prescribe the correct dosing schedule based on your specific needs and response to the treatment. It is crucial to follow your doctor’s instructions and not to exceed the recommended daily dose of one injection per 24 hours.
Relistor is typically taken as needed for constipation, rather than on a strict daily schedule for all users. If you miss a dose on a day you need it, simply take it as soon as you remember. However, you should not take more than one dose within a 24-hour period. If you have any questions about a missed dose, consult your pharmacist or doctor for guidance.
Relistor treatment guidance often suggests stopping other laxative medications before you begin your injections. Using multiple laxatives at the same time can increase the risk of side effects like diarrhea and stomach cramps. Your healthcare provider will give you specific instructions on how to discontinue your previous laxatives and when to start using Relistor for the best results.
Relistor is not likely to cause systemic opioid withdrawal symptoms like anxiety or chills in most patients. The medication is designed to work primarily on the gut and not to enter the brain. However, if you have a disruption in the blood-brain barrier, there is a small risk. Contact your doctor if you experience any unusual symptoms after taking your dose.
Relistor should not reduce the effectiveness of your opioid pain medication. It is specifically designed as a peripherally acting antagonist, meaning it blocks opioid effects in the gut without crossing into the central nervous system where pain relief occurs. This allows it to relieve constipation while preserving your pain management regimen. You can continue your prescribed pain treatment as directed.
The most common side effects of Relistor are typically related to the gastrointestinal tract. These include abdominal pain, nausea, and diarrhea as the medicine starts to work. Some people may also experience hot flushes, chills, or sweating. These effects are usually mild and temporary. If any side effect becomes severe or bothersome, you should contact your doctor.
Relistor is administered as a subcutaneous injection, which means it goes into the fatty tissue just under the skin. The recommended injection sites are the upper thigh, the abdomen (avoiding the two inches around the navel), or the upper arm. It is important to rotate the injection site with each dose to prevent skin irritation or other issues at the injection location.
Relistor pre-filled syringes should be stored at room temperature, which is between 68°F to 77°F (20°C to 25°C). It is important to keep them in their original packaging to protect them from light. You should not freeze the syringes, as this can damage the medication. Always keep Relistor and all other medicines out of the reach of children and pets.
Relistor is not intended for treating constipation that is not caused by opioid use. Its mechanism of action is specific to blocking opioid receptors in the gut. For other types of constipation, different treatments like dietary changes, lifestyle adjustments, or other types of laxatives are typically recommended. Your doctor can determine the cause of your constipation and the most appropriate treatment.
Relistor does not have a direct, major interaction with alcohol. However, alcohol can sometimes worsen side effects like nausea or dizziness. It is generally wise to moderate your alcohol intake while undergoing any medical treatment. Always consult with your healthcare provider for personalized advice regarding alcohol consumption while you are using this or any other prescription medication.
Relistor can cause temporary stomach cramping as it begins to work, but severe or persistent pain is not normal. If you experience severe abdominal pain after an injection, you should contact your doctor immediately. This could be a sign of a rare but serious side effect, such as a tear in the intestinal wall (perforation), which requires prompt medical evaluation and attention.
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