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    Progesterone Micronized

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Prometrium oral medication boosts the levels of the hormone progesterone. It is an important component of Hormone Replacement Therapy for women.

Prescription Required
30 Capsules
15 Capsules
*Please note all prices are in US dollars

Prometrium (generic: progesterone micronized) is an oral medication that is prescribed when natural levels of the hormone progesterone have declined due to aging, irregular periods, or surgical interventions such as the removal of the uterus. Micronized progesterone most closely mimics the natural form of the hormone produced by the body.

There are several causes of low progesterone, including anovulation (the ovary doesn’t release an egg), polycystic ovary syndrome (PCOS), excess levels of cortisol (the stress hormone), hypothyroidism, hyperprolactinemia, or low levels of cholesterol.

The most common cause is the passage into perimenopause, which is when female hormone levels start to generally decline.


The dosage was determined by the prescribing doctor based on medical conditions and response to therapy. It should only be altered by consulting a healthcare professional.

Recommended dosing is once a day, at bedtime – unless suggested otherwise by a healthcare provider.  

Some mild side effects have been reported. These may include:

  •  Breast tenderness
  •  Vaginal itching or discharge
  •  Breakthrough bleeding, spotting, changes in menstrual flow, painful periods
  •  Nausea, vomiting, bloating, abdominal pain
  •  Dizziness
  •  Headache (including migraine)
  •  Blurred vision
  •  Mood disturbances, and irritability.

Tell your doctor, nurse or pharmacist if any of these affects you severely.

Sometimes, more serious side effects have been reported. In such a case, stop taking the medication and talk immediately with a healthcare professional. The side effects are:

  • Nausea and vomiting that doesn’t stop
  • mood changes, depression, or memory loss
  • breast lumps
  • unusual vaginal bleeding such as spotting, breakthrough bleeding, prolonged or recurrent bleeding
  • increased or new vaginal irritation, itching, odor or discharge
  • severe stomach or abdominal pain
  • yellowing around the eyes or on the skin 
  • dark urine
  • swelling of the hands, ankles or feet
  • increased thirst
  • increased and more frequent urination
  • excessive tiredness.

There have been some cases of severe allergic reactions to this product. If symptoms like itching or swelling (especially of the face, tongue or throat), a rash, trouble breathing, or severe dizziness appear,  seek medical help immediately.

Prometrium can be prescribed for women who aren’t pregnant and are not going through menopause but whose menstrual periods have stopped for several months (amenorrhea). It can restore the normal cycle.

Progesterone is also used in combination with estrogen as part of hormone replacement therapy (HRT) to reduce menopause symptoms, such as hot flashes, night sweats, discomfort during sex, and feelings of loss of self.

Progesterone is added to estrogen in hormone replacement therapy in order to reduce the risk of cancer of the uterus.

  • What causes progesterone to decline?

    Reductions in the levels of progesterone can be caused by many different factors. The main cause is aging, with levels dropping significantly once a woman enters menopause. Obesity, chronic stress, smoking and a poor diet can also contribute to low progesterone. Diseases such as hypothyroidism (underactive thyroid) and hyperprolactinemia (elevated prolactin) are direct causes of lower progesterone.
  • How do you know if your progesterone is dropping?

    Symptoms of reduced progesterone levels in menopause include lower libido, hot flashes, migraines or headaches, depression, anxiety or other mood changes. For premenopausal women, there can be menstrual cycle irregularity or absence.
  • Is it better to take progesterone when taking estrogen?

    For women who have not undergone surgical removal of the uterus, doctors will typically prescribe estrogen together with progesterone or progestin medications. This is necessary due to the risk coming from estrogen alone, which, when not balanced by progesterone, can stimulate the growth of the lining of the uterus, which increases the risk of endometrial cancer.
  • What progesterone is best for HRT?

    The type of progestogen that most closely matches the natural form produced in the body is called 'micronised' progesterone. This has the same molecular structure as the progesterone produced in the body. This will produce fewer side effects than other types of progestogens.
  • Should you take progesterone without estrogen?

    Estrogen taken together with progesterone is usually used for menopausal HRT. This is due to the fact that estrogen taken alone can cause the lining of the uterus to thicken. This increases the risk of endometrial cancer. In some cases, doctors may prescribe progesterone on its own without estrogen


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