What does “immunomodulatory drug (IMiD)” mean in myeloma care?

An immunomodulatory drug is a medicine that changes immune activity and the tumor environment in ways that can slow myeloma growth. Members of this group are used widely in relapsed or persistent disease. They are taken by mouth on planned schedules and are often combined with other treatments to improve control. Because IMiDs can lower blood counts, regular lab checks are part of routine care. This class also carries special pregnancy-prevention rules due to the risk of severe birth defects, so safe-use steps are built into every treatment plan.

What is multiple myeloma in simple terms?

Multiple myeloma is a cancer of plasma cells, a type of white blood cell found in bone marrow. These cancer cells build up and crowd out healthy blood-forming cells. Common problems include bone pain, frequent infections, anemia-related tiredness, and high calcium or kidney issues. Doctors track the disease using blood tests, urine tests, scans, and sometimes bone marrow checks. Treatment is usually a combination of medicines given in cycles. Over time, plans may change as the disease responds or returns, and as new symptoms or side effects appear.

What safety programs and pregnancy rules apply to pomalidomide?

Medicines in this group can cause severe birth defects. For that reason, pomalidomide is dispensed under strict pregnancy-prevention rules. People who can become pregnant typically need negative pregnancy tests before starting and during treatment, plus proven birth control during treatment and for a set time after the last dose. People who can make a partner pregnant are generally advised to use condoms during treatment and for a set period afterward. Blood and sperm donation are usually not allowed during treatment and shortly after stopping. These steps aim to prevent fetal exposure at any time.

How does pomalidomide work in multiple myeloma?

Pomalidomide acts through several pathways. It affects signals inside myeloma cells that control growth and survival, making those cells more likely to stop dividing. It also changes the local environment in the bone marrow, which can reduce support for tumor growth. In addition, it boosts parts of the immune system so immune cells can better recognize and attack myeloma cells. Because it works in more than one way, pomalidomide can help even when earlier treatments stop working. Its effects build over repeated cycles, so steady use within the scheduled plan is important.

How is Pomalyst taken and for how long?

Pomalyst is taken by mouth once daily in treatment cycles. Common schedules include 21 days on medicine followed by 7 days off, or other cycle designs when combined with additional drugs. Tablets are swallowed whole and are usually taken at the same time each day. Therapy often continues as long as benefits outweigh risks, which is decided by the care team after checking blood counts, symptoms, and scans. If serious side effects occur, such as very low blood counts or a severe skin reaction, the dose may be paused or adjusted according to the treatment plan.

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Home / Online Pharmacy / Pomalyst

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US Name:

Pomalyst
Alternative Names:

Imnovid
Active Ingredients:

Pomalidomide
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Pomalyst ^*

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Pomalyst is an anti-cancer medicine used in adults with multiple myeloma.

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Imnovid Brand	4mg 21 Capsules	- Pomalyst – Brand, Imnovid, 4mg, 21, Capsules, 77992, Bristol Myers Squibb, 2765 + 0	Our price: $7,325.00
Imnovid Brand	3mg 21 Capsules	- Pomalyst – Brand, Imnovid, 3mg, 21, Capsules, 65785, Bristol Myers Squibb, 2764 + 0	Our price: $6,720.00
Imnovid Brand	2mg 21 Capsules	- Pomalyst – Brand, Imnovid, 2mg, 21, Capsules, 77869, Bristol Myers Squibb, 2763 + 0	Our price: $8,080.00
Imnovid Brand	1mg 21 Capsules	- Pomalyst – Brand, Imnovid, 1mg, 21, Capsules, 65781, Bristol Myers Squibb, 2762 + 0	Our price: $7,500.00

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Description
Side Effects
Indications
FAQ
Video

Pomalyst (generic name: pomalidomide) is an anti-cancer medicine used in adults with multiple myeloma. It contains pomalidomide, which works in several ways: it slows the growth of myeloma cells, helps the immune system find and attack them, and reduces the formation of new blood vessels that feed tumors.

Doctors usually prescribe it together with dexamethasone, and in some cases also with bortezomib. These combinations are used in people whose myeloma has returned or gotten worse after other treatments. Pomalyst is taken in planned treatment cycles and is meant for regular, day-to-day use during each cycle, not for sudden symptom relief.

Pomalidomide can severely harm an unborn baby. The leaflet requires strict pregnancy-prevention steps for females who can become pregnant and condom use for males with partners who can become pregnant; pregnancy tests and contraception continue during treatment and for at least 4 weeks after the last dose. Do not donate sperm or blood during treatment and for 4 weeks after stopping.

Dosage

It is important to follow the dosage instructions printed on the label of the box. Check with a doctor or pharmacist if there are any doubts regarding the proper dosage and treatment regimen.

Pomalyst is prescribed by specialists and used with other medicines. The usual starting dose is 4 mg once daily, taken by mouth, and given in cycles with planned “on” and “off” days. When used with bortezomib and dexamethasone, cycles are 21 days long; some days include all three medicines, some days two, one, or none, following the chart your care team provides. When used with dexamethasone only, cycles are 28 days long, again following a day-by-day chart. After each cycle, a new cycle starts unless the doctor tells the patient to stop. Tablets can be taken with or without food. Take the dose at the same time each day.

This is a maintenance, cyclical therapy. Keep taking it exactly as scheduled during each cycle, even if symptoms improve. It is not for immediate relief of symptoms. If a dose is missed, do not take two doses together; take the next dose at the regular time the next day. If too much is taken, contact a doctor or emergency service and take the package with you. Treatment usually continues until the doctor instructs to stop, based on response and safety checks.

Storage

Keep in the original package to protect from light. Store below 25°C (72°F). Do not use after the expiry date on the pack.

This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication.
The information leaflet that comes with the medication includes full information about the correct usage, storage and possible side effects. Be sure to read and understand these, and if there are any questions, discuss these with a healthcare provider or pharmacist before starting treatment.

Caution:

If a sudden allergic reaction (anaphylaxis) occurs shortly after taking Pomalyst, with symptoms like swelling of the face, tongue, or throat making it difficult to breathe or swallow, or there is wheezing, hives, rash, blistering, or peeling of the skin, call a doctor or 911 right away, or go to an emergency room immediately.

Pregnant women should not be using Pomalyst unless this has been discussed with a healthcare provider, as it might harm the unborn baby or pose a risk of miscarriage. For this reason, women planning to become pregnant should use appropriate birth control measures during the treatment and one month after taking the last dose of Pomalyst.

Most people who use Pomalyst do not experience any adverse side effects. Doctors prescribe this medication because they assess the benefits of such treatment outweigh any likely unwanted effects.]

Some of the side effects that have been reported include:

infections of the chest or lungs (pneumonia/bronchitis), or nose and throat;
shortness of breath;
low red blood cells (anemia) causing tiredness or weakness;
constipation, diarrhea, nausea or vomiting;
trouble sleeping, dizziness or tremor;
numbness or tingling in hands or feet;
swelling of the body or legs;
rashes or itchy skin.

Serious side effects may include fever or chills with a sore throat (signs of low white cells or serious infection), unexpected bleeding or bruising, chest pain or painful swollen leg (blood clots), severe skin rash, yellowing of the skin/eyes (liver problems), or sudden swelling of the face and throat with trouble breathing (allergic reaction). Seek urgent medical help.

Not all side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.

Multiple myeloma is a blood cancer of plasma cells in the bone marrow. These cells build up and crowd out healthy cells. People may have bone pain, frequent infections, anemia (tiredness, weakness), weight loss, kidney problems, or high calcium. Pomalyst is used with other medicines when myeloma has relapsed (come back) or progressed after previous treatments. It can delay the disease from getting worse and help control symptoms. Treatment comes in cycles, and simple blood tests are used to monitor safety and effect.

An immunomodulatory drug is a medicine that changes immune activity and the tumor environment in ways that can slow myeloma growth. Members of this group are used widely in relapsed or persistent disease. They are taken by mouth on planned schedules and are often combined with other treatments to improve control. Because IMiDs can lower blood counts, regular lab checks are part of routine care. This class also carries special pregnancy-prevention rules due to the risk of severe birth defects, so safe-use steps are built into every treatment plan.
Multiple myeloma is a cancer of plasma cells, a type of white blood cell found in bone marrow. These cancer cells build up and crowd out healthy blood-forming cells. Common problems include bone pain, frequent infections, anemia-related tiredness, and high calcium or kidney issues. Doctors track the disease using blood tests, urine tests, scans, and sometimes bone marrow checks. Treatment is usually a combination of medicines given in cycles. Over time, plans may change as the disease responds or returns, and as new symptoms or side effects appear.
Medicines in this group can cause severe birth defects. For that reason, pomalidomide is dispensed under strict pregnancy-prevention rules. People who can become pregnant typically need negative pregnancy tests before starting and during treatment, plus proven birth control during treatment and for a set time after the last dose. People who can make a partner pregnant are generally advised to use condoms during treatment and for a set period afterward. Blood and sperm donation are usually not allowed during treatment and shortly after stopping. These steps aim to prevent fetal exposure at any time.
Pomalidomide acts through several pathways. It affects signals inside myeloma cells that control growth and survival, making those cells more likely to stop dividing. It also changes the local environment in the bone marrow, which can reduce support for tumor growth. In addition, it boosts parts of the immune system so immune cells can better recognize and attack myeloma cells. Because it works in more than one way, pomalidomide can help even when earlier treatments stop working. Its effects build over repeated cycles, so steady use within the scheduled plan is important.
Pomalyst is taken by mouth once daily in treatment cycles. Common schedules include 21 days on medicine followed by 7 days off, or other cycle designs when combined with additional drugs. Tablets are swallowed whole and are usually taken at the same time each day. Therapy often continues as long as benefits outweigh risks, which is decided by the care team after checking blood counts, symptoms, and scans. If serious side effects occur, such as very low blood counts or a severe skin reaction, the dose may be paused or adjusted according to the treatment plan.

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