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For visual reference only; actual product may vary
US Name:
Opsumit
Alternative Names:
Opsumit
Active Ingredients:
Macitentan
Brand Manufacturer:
Manufacturer Location:
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For visual reference only; actual product may vary
Opsumit (macitentan) is a daily prescription medicine for pulmonary arterial hypertension (PAH). It helps improve exercise ability and delay disease progression. By relaxing pulmonary arteries, it reduces strain on the heart, helping to lower the risk of PAH-related hospitalization for a better quality of life.
| Opsumit Brand | 10mg 30 Tablets |
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Our price: $2,900.00 |
Opsumit is a prescription oral medication used to treat pulmonary arterial hypertension (PAH) in adults. Its generic name is macitentan. This treatment is specifically for patients with WHO Group I PAH. Opsumit helps slow down the worsening of the disease. It also reduces the risk of being hospitalized due to PAH. By managing symptoms, it can improve your ability to be physically active. It is not a cure but a long-term therapy.
Opsumit works by blocking the effects of endothelin, a substance in the body that causes blood vessels to narrow. As a dual endothelin receptor antagonist, it targets and blocks two key receptors (ET-A and ET-B). This action helps relax the blood vessels in the lungs. Relaxing these vessels decreases the high blood pressure in the pulmonary arteries. This process, known as vasodilation, reduces the strain on the right side of the heart. It also helps prevent harmful changes in the structure of the arteries.
Opsumit is for adults diagnosed with pulmonary arterial hypertension, specifically WHO Group I. This group includes patients whose PAH is not caused by other underlying heart or lung diseases. The medication is prescribed to help delay the progression of the disease. It aims to improve exercise capacity and general quality of life. Patients who want to lower their chances of hospitalization for PAH may benefit. It is not for pregnant women due to the risk of serious birth defects.
Opsumit is prescribed as a 10 mg tablet to be taken once per day. You can take the tablet with or without food. It is important to swallow the tablet whole. Do not crush, split, or chew it. Try to take your dose at the same time each day to maintain stable levels of the medicine in your body. If you miss a dose, take it as soon as you remember on the same day. Never take a double dose to make up for a missed one.
Opsumit may cause side effects, though not everyone experiences them. Common side effects include headache, stuffy nose, sore throat, and bronchitis. Some patients may also develop anemia, which is a low red blood cell count. Your doctor will monitor this with blood tests. More serious side effects can occur. These include liver problems and fluid retention. Seek medical help right away if you notice yellowing skin, dark urine, or unusual swelling. This medication can cause serious birth defects. It must not be taken during pregnancy.
Opsumit is a crucial medication for managing a serious condition, and IsraelPharm provides a reliable, cost-effective source. We are committed to patient safety and satisfaction. Our licensed pharmacists are available to answer your questions and provide support. We ensure every medication is authentic and sourced from legitimate suppliers. By ordering from IsraelPharm, you get convenient access to your prescribed treatment at competitive prices. We handle your health with the professionalism and care you deserve, delivering your medication discreetly to your door.
Common side effects of Opsumit can include:
Seek immediate medical attention if you experience signs of a serious reaction, such as:
Opsumit is an FDA-approved prescription medication used for the treatment of:
Opsumit begins to work within the first few weeks of treatment, but its full benefits may take longer to become apparent. Patients often notice gradual improvements in symptoms like shortness of breath and fatigue. The primary goal of Opsumit is to slow the progression of pulmonary arterial hypertension over the long term, reducing the need for hospitalization and improving quality of life.
Opsumit can be taken with or without food based on your preference. The medication's effectiveness is not significantly affected by meals. It is most important to take your dose at the same time each day to maintain a consistent level of the drug in your body. Always follow the specific instructions provided by your healthcare provider for the best results.
Opsumit should be taken as soon as you remember if it is still the same day. However, if you do not remember until the next day, you should skip the missed dose entirely. Do not take two doses at once to make up for the missed one, as this can increase your risk of side effects. Simply continue with your regular daily dosing schedule.
Opsumit may have interactions with alcohol, so it's best to discuss your alcohol use with your doctor. Alcohol can sometimes worsen side effects like dizziness or low blood pressure. Your doctor can provide personalized advice based on your overall health and treatment plan to ensure your safety while taking this medication for pulmonary arterial hypertension.
Opsumit carries a risk of causing liver injury, so your doctor will monitor your liver function with blood tests before and during treatment. You should immediately report symptoms like yellowing skin or eyes (jaundice), unusual fatigue, dark urine, or upper right stomach pain. While not common, these can be signs of serious liver damage requiring immediate medical attention.
Opsumit is known to cause severe birth defects and harm to a developing fetus. For this reason, it is strictly forbidden for use during pregnancy. Women who can become pregnant must have a negative pregnancy test before starting the medication and use effective birth control throughout treatment and for one month after stopping. It is only available through a restricted program.
Opsumit should not be stopped suddenly without first consulting your doctor. Abruptly discontinuing the medication can lead to a worsening of your pulmonary arterial hypertension symptoms. Your healthcare provider will guide you on a safe way to stop the medication if necessary, ensuring a smooth transition and proper management of your condition.
Opsumit works by relaxing the blood vessels in the lungs, which lowers the high pressure there. While its primary effect is on the pulmonary arteries, it can also cause a slight decrease in your overall systemic blood pressure. This may lead to symptoms like dizziness or lightheadedness, especially when you first start taking the medication.
Opsumit tablets should be stored at a controlled room temperature, between 68°F to 77°F (20°C to 25°C). Keep the medication in its original container to protect it from moisture and light. Do not store it in a humid environment like a bathroom. Always ensure it is kept safely out of the reach of children and pets.
Opsumit can cause a decrease in hemoglobin levels, leading to anemia, which is a low red blood cell count. Your doctor will perform blood tests to check your red blood cells before you start and during your treatment. Common symptoms of anemia can include unusual tiredness, weakness, paleness, or increased shortness of breath. Inform your doctor if you experience any of these symptoms.
Opsumit's most frequently reported side effects include headache, stuffy or runny nose (nasopharyngitis), sore throat, and bronchitis. Some people may also experience flu-like symptoms or a urinary tract infection. While many of these are mild, you should contact your doctor if they persist or become bothersome. Many people taking Opsumit have no serious side effects.
Opsumit can interact with several other drugs, which may change its effectiveness or increase side effect risks. It is critical to tell your doctor about all medicines you take, including prescriptions, over-the-counter drugs, and herbal supplements. Strong CYP3A4 inhibitors, like ketoconazole for fungal infections, must be avoided as they significantly increase Opsumit levels in your blood.
Opsumit is not a cure for pulmonary arterial hypertension (PAH), but it is a highly effective long-term treatment. Its purpose is to manage the condition by slowing its progression, improving symptoms like fatigue, and enhancing your ability to exercise. Taking it consistently helps to reduce the likelihood of being hospitalized due to PAH.
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