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For visual reference only; actual product may vary
For visual reference only; actual product may vary
Mavenclad (cladribine) is a short-course oral therapy for adults with relapsing forms of multiple sclerosis (MS). It is taken over two brief treatment courses, one year apart, to reduce relapse rates and help slow disability progression. This unique dosing simplifies long-term management for highly active MS.
| Mavenclad Brand | 10mg 1 Tablets |
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Our price: $3,800.00 |
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| Mavenclad Brand | 10mg 4 Tablets |
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Our price: $15,233.00 |
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| Mavenclad Brand | 10mg 6 Tablets |
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Our price: $22,850.00 |
Mavenclad is a prescription oral medication used to treat relapsing forms of multiple sclerosis (MS) in adults. This includes relapsing-remitting disease (RRMS) and active secondary progressive disease (SPMS). It is generally recommended for patients who have not responded well to, or cannot tolerate, other MS drugs. Mavenclad is not a daily medication. It is a short-course therapy that is given in two treatment courses over two years. This unique dosing schedule provides a lasting effect on the immune system.
Mavenclad works by selectively targeting and reducing the number of certain white blood cells called lymphocytes (B cells and T cells). In multiple sclerosis, these immune cells mistakenly attack the protective myelin sheath that covers nerve fibers in the brain and spinal cord. By temporarily lowering the lymphocyte count, Mavenclad reduces this autoimmune attack. This action helps to decrease the frequency of MS relapses. It also slows down the worsening of disability that can occur with the disease. The effect on the immune system is long-lasting, even after the short treatment courses are complete.
Mavenclad is designed for adults diagnosed with highly active relapsing forms of multiple sclerosis. This includes patients with relapsing-remitting MS and active secondary progressive MS. Because of its safety profile, it is typically used in patients who have tried another MS medication that did not work well enough. It may also be an option for those who could not tolerate other treatments. It is not recommended for patients with clinically isolated syndrome. Patients considering Mavenclad should have a thorough discussion with their neurologist to weigh the benefits and potential risks.
Mavenclad is taken orally as tablets in a unique short-course schedule. The entire treatment is completed over two years. Each year involves one treatment course. A course consists of two treatment weeks, separated by about one month. In each treatment week, a patient takes tablets for 4 or 5 consecutive days. The total number of tablets depends on the patient’s body weight. After the second treatment course in year two, no further Mavenclad treatment is required in years three and four. This specific dosing regimen must be followed precisely under a doctor’s supervision.
Mavenclad can cause side effects, some of which may be serious. The most common side effect is a decrease in white blood cells known as lymphopenia. This can increase your risk of infections. Other common side effects include headaches, upper respiratory tract infections, and cold sores. Serious risks associated with Mavenclad include an increased risk of certain cancers, serious infections like tuberculosis and hepatitis, and potential liver injury. Your doctor will monitor you closely with blood tests before, during, and after treatment to manage these risks. It is crucial to report any new or worsening symptoms to your healthcare provider immediately.
IsraelPharm offers a reliable and affordable way to access your essential medications like Mavenclad. We are committed to providing authentic, brand-name drugs sourced from a regulated supply chain. Our prices are competitive, helping you save on your long-term treatment costs. Our knowledgeable, licensed pharmacists are available to answer your questions and provide support throughout your treatment journey. With our focus on customer service and secure, discreet shipping to your door, IsraelPharm makes managing your health simpler and more accessible. Trust us to be your partner in healthcare.
Mavenclad can cause a range of side effects. You should always discuss these with your doctor.
Mavenclad is indicated for the treatment of adults with relapsing forms of multiple sclerosis (MS), including:
Due to its safety profile, its use is generally reserved for patients who have had an inadequate response to, or are unable to tolerate, an alternative drug for MS.
Mavenclad is an oral tablet medication taken in two annual treatment courses. Each course consists of two treatment weeks, spaced about a month apart. During each of these weeks, you will take tablets for 4 or 5 days. After completing the course in year two, no further treatment is needed for the next two years. Your doctor will provide a specific schedule based on your weight.
Mavenclad treatment requires careful monitoring by your healthcare provider. You will need regular blood tests to check your lymphocyte counts before, during, and after each treatment course. This helps your doctor manage your risk of infection. Liver function tests and screening for infections like tuberculosis and hepatitis are also performed before you start. Ongoing monitoring ensures the treatment is both safe and effective for you.
Mavenclad may require you to be cautious with alcohol consumption. Alcohol can also be processed by the liver, and since Mavenclad carries a risk of liver injury, it is wise to limit intake. Heavy alcohol use could potentially add stress to the liver. You should discuss your alcohol use with your doctor before starting treatment to get personalized advice based on your overall health and liver function.
Mavenclad itself has a short half-life and is cleared from the body relatively quickly. However, its effects on the immune system are long-lasting. The medication works by reducing certain white blood cells, and it takes time for these cell counts to return to normal levels. This extended biological effect is what allows for the short-course dosing with a lasting impact on MS activity over several years.
Mavenclad must not be used by women who are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Both men and women must use effective contraception during treatment and for at least 6 months after the final dose. If you are considering starting a family, it is critical to have a detailed discussion with your doctor about timing and safety.
Mavenclad increases your risk of developing infections because it lowers your white blood cell count. If you develop signs of an infection, such as a fever, cough, flu-like symptoms, or painful urination, you must contact your doctor right away. Your doctor may need to delay your treatment or prescribe medication to treat the infection. Prompt medical attention is essential to prevent it from becoming serious.
Mavenclad may cause some hair thinning or mild hair loss in a small percentage of patients. This side effect is generally not as severe as the hair loss associated with chemotherapy for cancer. In clinical studies, it was reported as an uncommon side effect. If you experience distressing hair thinning while on Mavenclad, you should speak with your healthcare provider for advice and reassurance.
Mavenclad tablets should be stored in their original packaging to protect them from moisture and light. Keep the medication at room temperature, between 68°F to 77°F (20°C to 25°C). It is important to store Mavenclad in a place that is out of reach of children and pets. Do not store it in a bathroom or other damp area. Always check the expiration date before use.
Mavenclad can interact with other medicines, which may alter its effectiveness or increase the risk of side effects. It is very important to tell your doctor about all the medications you take. This includes prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. Specifically, drugs that suppress the immune system or affect blood cell counts should be reviewed carefully with your doctor before you start treatment.
Mavenclad belongs to a class of drugs called antimetabolites, which are also used in chemotherapy for cancer, but its use in MS is different. For multiple sclerosis, Mavenclad is used at a much lower dose and targets the immune system specifically. It is therefore considered an immunomodulatory therapy, not traditional chemotherapy. The goal is to modify the immune response rather than broadly destroy cells.
Mavenclad differs from many other MS drugs primarily in its dosing schedule. Instead of a daily pill or frequent injection, it is an oral treatment given in two short courses over two years. This provides a long-lasting effect without the need for continuous therapy. It is also often reserved for patients with highly active disease or who have not had success with other treatments due to its specific risk-benefit profile.
Mavenclad follows a very strict dosing schedule, so missing a dose requires immediate attention. If you miss a tablet, you must call your healthcare provider right away for instructions. Do not simply take an extra tablet to make up for it. Your doctor will need to advise you on the correct way to proceed to ensure your treatment course remains safe and effective.
Mavenclad treatment requires careful planning around vaccinations because it affects your immune system. You should not receive live or live-attenuated vaccines while you are being treated. It is recommended to complete any necessary vaccinations 4 to 6 weeks before starting your first course of Mavenclad. Always discuss your vaccination plans with your doctor to ensure your safety and the vaccine’s effectiveness.
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