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  • US Name:

    Lorbrena

  • Alternative Names:

    Lorviqua

  • Active Ingredients:

    Lorlatinib

  • Brand Manufacturer:

  • Manufacturer Location:

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Lorbrena *

For visual reference only; actual product may vary

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Lorbrena (lorlatinib) is an oral targeted therapy medication used to treat adult patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC). It works by blocking specific enzymes that promote cancer cell growth. It is taken once daily as a film-coated tablet.

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Lorviqua Brand 100mg
30 Tablets
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$9,306.00
*Please note all prices are in US dollars

What is Lorbrena?

Lorbrena is an oral prescription medication used to treat a specific type of lung cancer. It is prescribed for adults with non-small cell lung cancer (NSCLC) that has spread to other parts of the body. The cancer must also be “ALK-positive.” This means the cancer cells have a mutation in the anaplastic lymphoma kinase (ALK) gene. Lorbrena is a targeted therapy. This means it specifically attacks the cancer cells with this genetic marker. It is often used when other treatments are no longer effective. This medication helps to slow down or stop the growth of cancer cells.

How does Lorbrena work?

Lorbrena works by blocking the activity of the mutated ALK protein in cancer cells. This protein acts like a switch that is always “on,” telling cancer cells to grow and divide uncontrollably. Lorbrena, which is a type of drug called a kinase inhibitor, effectively turns this switch “off.” By inhibiting the ALK protein, it disrupts the signals that cancer cells need to survive and multiply. This action can shrink tumors or slow their progression. Lorbrena is also effective at treating cancer that has spread to the brain. It can cross the blood-brain barrier, a protective layer that stops many other drugs.

Who is Lorbrena for?

Lorbrena is prescribed for adult patients diagnosed with metastatic ALK-positive non-small cell lung cancer. This medication is specifically for patients whose cancer cells have the ALK gene rearrangement. It is often considered a second- or third-line treatment. This means it may be prescribed after a patient’s cancer has progressed despite treatment with other ALK inhibitors like crizotinib, alectinib, or ceritinib. A doctor will confirm the presence of the ALK mutation through a specific test before prescribing Lorbrena. It is not suitable for all types of lung cancer.

Dosage and administration

Lorbrena is typically taken as a once-daily oral tablet, with the standard dose being 100 mg. You should take the tablet at the same time each day. It can be taken with or without food. Swallow the tablet whole; do not chew, crush, or split it. If you vomit after taking a dose, do not take an extra dose. Just take your next dose at the regular time. Your doctor will determine the correct dosage for you. The treatment continues until the disease progresses or you experience unacceptable side effects. Always follow your doctor’s instructions carefully.

Side effects

Lorbrena may cause several side effects, which can range from mild to serious. It is important to discuss these with your doctor. Many people taking Lorbrena experience changes in their blood cholesterol or triglyceride levels. Other common side effects include swelling in the arms, legs, hands, and feet (edema), numbness or tingling in the hands or feet (peripheral neuropathy), weight gain, and mood or thinking changes. More serious side effects can occur. These may include severe lung problems, central nervous system effects like confusion or seizures, liver problems, and a slow heart rate. Contact your healthcare provider immediately if you experience chest pain, shortness of breath, or severe dizziness.

Why buy from IsraelPharm?

IsraelPharm provides a reliable and affordable way to purchase Lorbrena online. We are committed to making important medications accessible to patients in the US. Our platform offers significant savings compared to typical retail prices. This ensures you can afford your treatment without added financial stress. We source our medications from trusted suppliers, guaranteeing their authenticity and quality. With a straightforward ordering process and discreet, direct-to-your-door shipping, IsraelPharm is a secure and convenient choice for your prescription needs. Our customer service team is always available to assist you.

Common Side Effects:

  • High cholesterol or high triglycerides
  • Swelling of the hands, feet, or face (edema)
  • Numbness, tingling, or pain in the hands or feet (peripheral neuropathy)
  • Weight gain
  • Cognitive difficulties (trouble with memory or concentration)
  • Mood changes (irritability, anxiety)
  • Tiredness (fatigue)
  • Diarrhea or constipation
  • Shortness of breath

Serious Side Effects:

  • Central nervous system (CNS) effects, including seizures, hallucinations, or severe confusion
  • Serious lung problems (pneumonitis) that can lead to death
  • Liver problems (hepatotoxicity)
  • Very slow heart rate (bradycardia)
  • High blood pressure (hypertension)
  • High blood sugar (hyperglycemia)
  • Treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive.

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