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For visual reference only; actual product may vary
For visual reference only; actual product may vary
Lonsurf is a prescription oral chemotherapy medication. It contains trifluridine and tipiracil. This combination drug is used to treat adults with metastatic colorectal cancer or metastatic gastric cancer. It is typically prescribed after other cancer treatments have been tried. Lonsurf works by slowing or stopping the growth of cancer cells.
| Lonsurf Brand | 20 mg / 8.19 mg 20 Tablets |
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Our price: $1,111.00 |
Lonsurf is a prescription combination chemotherapy drug used to treat advanced cancers. It contains two active ingredients: trifluridine and tipiracil. This medication is approved for patients with metastatic colorectal cancer. It is also used for metastatic gastric cancer, including adenocarcinoma of the gastroesophageal junction. Lonsurf is usually considered after other types of chemotherapy or targeted therapies have stopped working. It belongs to a class of drugs known as nucleoside metabolic inhibitors.
Lonsurf works through a dual-action process to fight cancer cells. The first component, trifluridine, is a nucleoside analog. It incorporates itself into the DNA of cancer cells. This action disrupts the DNA’s function and prevents the cells from dividing. The second component, tipiracil, plays a supportive role. It stops an enzyme that would normally break down trifluridine. This allows trifluridine to stay in the body longer at higher concentrations. The result is a more powerful anti-cancer effect.
Lonsurf is for specific adult patients with advanced stages of cancer. It is intended for individuals with metastatic colorectal cancer. These patients have typically already undergone treatment with other standard chemotherapies. Lonsurf is also approved for adults with metastatic gastric cancer or gastroesophageal junction adenocarcinoma. The medication provides a valuable treatment option for those whose disease has progressed despite prior treatments. A doctor will determine if Lonsurf is a suitable choice based on a patient’s medical history.
Lonsurf dosage and administration must be determined by a healthcare professional. The medication comes as oral tablets. It is taken twice a day, usually for five days a week, followed by two days of rest. This is repeated for two weeks, followed by a two-week rest period. This 28-day cycle continues as long as the treatment is beneficial and tolerated. The exact dose depends on body surface area and blood test results. Patients should swallow the tablets whole with a glass of water after meals.
Lonsurf can cause side effects, ranging from mild to severe. Common side effects include fatigue, nausea, vomiting, and diarrhea. Patients may also experience a loss of appetite and a decrease in white blood cells (neutropenia), red blood cells (anemia), and platelets (thrombocytopenia). Serious side effects can include severe bone marrow suppression. This may lead to life-threatening infections and bleeding. Your doctor will monitor your blood counts closely throughout treatment. Report any fever, chills, or unusual bleeding to your doctor immediately.
IsraelPharm offers a reliable and affordable way to access your medication. We source our products from licensed distributors, ensuring you receive authentic Lonsurf. Our streamlined international pharmacy service allows you to save on prescription costs without compromising quality. With a focus on patient care, our team is available to assist you with your order. We provide clear pricing and discreet shipping directly to your home. Choose IsraelPharm for a trusted source for your essential cancer treatments.
Common Side Effects:
Serious Side Effects:
Lonsurf is indicated for the treatment of adult patients with:
Lonsurf should be taken orally twice daily, within one hour after finishing your morning and evening meals. Your prescribing doctor will provide a specific dosing schedule, which typically involves a 28-day cycle. This usually means you take the tablets for five days, have two days off, and repeat this for two weeks, followed by a 14-day rest period. It is very important to follow your oncologist's instructions precisely for the best results.
Lonsurf requires a consistent dosing schedule, but if you miss a dose, you should not take an extra dose to make up for it. Simply skip the missed dose and resume your normal schedule with the next planned dose. Taking a double dose can increase your risk of severe side effects. Always inform your doctor or pharmacist about any missed doses during your next appointment for their records and guidance.
Lonsurf may cause hair thinning or hair loss (alopecia) in some patients, although it is not as common as with some other chemotherapy agents. The effect can range from slight thinning to more significant loss. This side effect is usually temporary, and hair typically begins to grow back after the treatment period is completed. Discuss any concerns you have about hair loss with your healthcare team for management strategies.
Lonsurf tablets should be stored at room temperature, which is between 68°F to 77°F (20°C to 25°C). Keep the medication in its original container to protect it from moisture and light. Be sure to store it in a location that is safely out of the reach of children and pets. Do not store it in a bathroom or other area with high humidity, as this can affect the medication's stability.
Lonsurf treatment requires regular blood tests to monitor your health and response to the drug. Because it can cause severe bone marrow suppression, your doctor will order complete blood counts (CBC) before you start and throughout your treatment. These tests check your levels of white blood cells, red blood cells, and platelets. The results help your doctor manage side effects and adjust your dose if necessary to keep you safe.
Lonsurf offers a unique mechanism of action compared to many other chemotherapies. It combines trifluridine, which damages cancer cell DNA, with tipiracil, which boosts trifluridine's effectiveness. This oral medication is often used after patients have already been treated with other standard injectable chemotherapies like fluoropyrimidines, oxaliplatin, and irinotecan. It provides a different way to attack cancer cells when the disease has progressed despite other treatments, extending the range of options available.
Lonsurf can put stress on your body, so it is generally wise to limit or avoid alcohol consumption during treatment. Alcohol can potentially worsen side effects like nausea, fatigue, or liver problems. It is very important to discuss your alcohol use with your doctor before starting therapy. Your healthcare provider can give you personalized advice based on your overall health, liver function, and other medications you may be taking.
Lonsurf treatment duration varies for each individual and is determined by your oncologist. Generally, you will continue to take Lonsurf for as long as it is effectively controlling the cancer and the side effects are manageable. Your doctor will regularly assess your condition through imaging scans and other tests to see how the cancer is responding. The treatment is given in 28-day cycles, which are repeated as necessary based on these evaluations.
Lonsurf can cause side effects like fatigue, dizziness, and weakness, which could impair your ability to drive or operate machinery safely. You should be cautious when you first start treatment until you know how the medication affects you. If you feel tired or unwell, do not drive. It is best to discuss this with your doctor, who can advise you based on your personal reaction to the drug and your overall health.
Lonsurf is not considered a cure for metastatic cancer, but it is an important treatment used to control the disease. For patients with advanced colorectal or gastric cancer, its primary goal is to slow down the growth and spread of cancer cells. This can help extend survival and improve quality of life. It is a palliative treatment, meaning it is focused on managing the disease when a cure is not possible.
Lonsurf can cause serious side effects, and you should watch for specific signs. The most critical one is severe bone marrow suppression. Symptoms include fever, chills, sore throat, or other signs of infection, which could mean your white blood cell count is too low. Unusual bruising or bleeding that won't stop may indicate a low platelet count. You should contact your doctor immediately if you experience any of these symptoms while taking this medication.
Lonsurf can interact with other medications, so it is crucial to inform your doctor about everything you take. This includes all prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. Your doctor needs a complete list to check for any potential interactions that could either reduce Lonsurf's effectiveness or increase your risk of harmful side effects. Do not start any new medication without first consulting with your healthcare provider to ensure it is safe.
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Off-label prescribing is legal in the United States and is governed by physician judgement.
