Lariam/Mefloquine (generic name: mefloquine) is an antimalarial medication used for both the prevention and treatment of malaria, particularly infections caused by Plasmodium falciparum and Plasmodium vivax. As a member of the quinoline-methanol pharmacological class, mefloquine interferes with the parasite’s ability to metabolize and utilize erythrocyte hemoglobin, leading to its death. This mechanism makes it effective against malaria strains resistant to other treatments. Mefloquine is typically administered orally and is known for its long half-life, which supports once-weekly dosing for prophylaxis. For more information, refer to the Centers for Disease Control and Prevention’s page on mefloquine.

Dosage

For malaria prevention, the standard adult dosage of mefloquine is 250 mg taken once weekly. It is recommended to start the medication at least one week before entering a malaria-endemic area, continue weekly during the stay, and for four weeks after leaving. For treatment of mild to moderate malaria, a single dose of 1,250 mg (five 250 mg tablets) is commonly prescribed. If a dose is missed, it should be taken as soon as remembered unless it is close to the time for the next dose; in such cases, skip the missed dose and resume the regular schedule. It is not advisable to double-dose.

Storage

Mefloquine tablets should be stored at room temperature, between 15°-30°C (59°-86°F). They should be kept in a tightly closed container, away from moisture and direct light. Refrigeration or freezing is not necessary. Always check the expiration date and dispose of unused or expired medication properly. For more information, read our article on drug storage.

Common Questions About Mefloquine

How should Lariam be taken for malaria prevention?

For prevention, Lariam is taken once weekly, starting at least one week before entering a malaria-endemic area, continuing during the stay, and for four weeks after leaving. It should be taken with food and a full glass of water.

What is the quinoline-methanol class of drugs?

Quinoline-methanol drugs, including mefloquine, are antimalarials that disrupt the metabolic processes of malaria parasites, making them effective for both prevention and treatment.

What is malaria, and how is it transmitted?

Malaria is a parasitic infection transmitted by the bite of an infected Anopheles mosquito. Symptoms include fever, chills, and fatigue, which can progress to severe complications without treatment.

How does mefloquine work?

Mefloquine disrupts the malaria parasite’s ability to metabolize hemoglobin, which is essential for its survival. This action ultimately leads to the parasite’s death.