For visual reference only; actual product may vary
For visual reference only; actual product may vary
Horizant (gabapentin enacarbil) is a prescription medication approved to treat moderate-to-severe primary restless legs syndrome (RLS) and nerve pain after shingles (postherpetic neuralgia). It helps calm nerve activity to reduce uncomfortable leg sensations and pain, helping you rest easier. It is taken orally, usually once daily.
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Horizant is a prescription medication used to treat two specific conditions in adults. It is primarily prescribed for moderate-to-severe primary restless legs syndrome (RLS). This condition causes unpleasant sensations and a strong urge to move your legs. Horizant is also approved for managing postherpetic neuralgia (PHN). PHN is a type of nerve pain that can linger after a shingles infection. This medication is a prodrug, which means it is converted into its active form, gabapentin, inside your body. It is designed for extended-release to provide long-lasting relief.
Horizant works by delivering its active ingredient, gabapentin enacarbil, to the body. Once absorbed, it converts into gabapentin. The exact way gabapentin works is not fully understood by scientists. However, it is believed to help calm overactive nerve signals in the nervous system. For restless legs syndrome, this action reduces the irresistible urge to move the legs. For postherpetic neuralgia, it helps to decrease the persistent nerve pain caused by the shingles virus. The extended-release formula helps maintain a stable level of the medication in your system.
Horizant is for adults diagnosed with specific neurological conditions by a healthcare provider. It is intended for patients with moderate-to-severe primary restless legs syndrome. These individuals experience significant discomfort and sleep disruption from RLS. The medication is also for adults suffering from nerve pain following a shingles outbreak. This condition is known as postherpetic neuralgia. Horizant is not approved for use in children. Your doctor will determine if this medication is appropriate for your specific symptoms and medical history.
Horizant is typically taken orally as a tablet that should not be crushed or chewed. For treating restless legs syndrome, the standard approach is a single dose taken with food at about 5 PM. For postherpetic neuralgia, the dosage may be split into two times per day. Your doctor will prescribe the exact dose based on your condition and kidney function. It is important to follow your doctor’s instructions precisely. Do not change your dose or stop taking the medication without consulting your healthcare provider. Consistency is key for managing your symptoms effectively.
Horizant can cause side effects, though many people have none or only minor ones. The most common side effects are dizziness and sleepiness. These effects are why driving should be avoided until you know how the drug affects you. Other potential side effects include headache, nausea, and fatigue. More serious risks exist, although they are rare. These can include new or worsening depression, suicidal thoughts, or unusual changes in mood or behavior. An allergic reaction is also a serious possibility. Always discuss potential side effects with your doctor before starting treatment.
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Like all medications, Horizant may cause side effects. Not everyone will experience them.
Contact your doctor immediately if you experience any of the following:
Horizant is primarily indicated for the treatment of two conditions:
Horizant may begin to relieve symptoms of restless legs syndrome (RLS) within the first week of treatment. However, it can take several weeks for you to feel the full therapeutic effects. For postherpetic neuralgia, a gradual improvement in nerve pain is often noticed over a few weeks. Consistency is important, so you should continue taking the medication as prescribed by your doctor even if you do not feel immediate relief.
Horizant is not the same as gabapentin, but it is closely related. Horizant contains gabapentin enacarbil, which your body converts into gabapentin after you take it. This formulation is designed to be absorbed more consistently and provide a steady, extended-release of the active medication. Standard gabapentin formulations may require more frequent dosing. You should not switch between them without a doctor's approval as they are not directly interchangeable.
Horizant should generally be taken with food. When prescribed for restless legs syndrome (RLS), it is recommended to be taken with a meal around 5 PM. Taking it with food helps your body absorb the medication properly and can enhance its effectiveness. For postherpetic neuralgia, your doctor will provide specific instructions on whether to take it with or without food, depending on your dosing schedule. Always follow your prescribing doctor's directions.
Horizant may cause dizziness and drowsiness, and alcohol can intensify these side effects. Combining alcohol with this medication can lead to excessive sleepiness and decreased mental alertness. It is strongly recommended to limit or avoid alcohol consumption while you are taking Horizant. This precaution helps prevent potential accidents and ensures your treatment is both safe and effective. Always discuss your alcohol use with your doctor.
Horizant dosage instructions depend on your condition. If you miss your RLS dose (taken at 5 PM), skip the missed dose and take your next one at the regular time on the following day. For PHN, if you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed one. Do not take two doses at once to make up for a missed one.
Horizant can cause significant drowsiness, dizziness, and decreased coordination, which can impair your ability to drive safely. You should not drive a car or operate heavy machinery until you know how this medication affects you. It is safest to avoid these activities, especially when you first start treatment or when your dose is increased. The effects can be strongest a few hours after taking your dose.
Horizant may cause weight gain as a potential side effect in some individuals. This is also a known side effect of gabapentin, which is the active form of the medication in the body. However, not everyone who takes Horizant will experience changes in weight. If you are concerned about weight gain while taking this medication, you should discuss it with your doctor. They can recommend dietary and exercise strategies to help manage your weight.
Horizant itself is not classified as a federal controlled substance in the United States. However, its active metabolite, gabapentin, is classified as a Schedule V controlled substance in some states due to a potential for misuse or abuse. This state-level classification means there may be extra rules for prescribing and dispensing it. Always use this medication exactly as prescribed by your doctor to ensure its safe and proper use.
Horizant may pose risks to an unborn baby, and its safety during pregnancy has not been definitively established. You should inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding before starting treatment. Your doctor will weigh the potential benefits of the medication against the potential risks to the fetus or infant. It may be necessary to explore alternative treatments during this time.
Horizant should not be stopped suddenly without consulting your doctor. Abruptly discontinuing the medication can lead to withdrawal symptoms, such as increased anxiety, difficulty sleeping, nausea, and pain. Your doctor will provide you with a plan to gradually reduce your dose over time. This tapering process helps minimize potential withdrawal effects and ensures a safe transition off the medication.
Horizant should be stored at room temperature, away from excess heat and moisture. Keep the medication in its original container with the lid tightly closed. Do not store it in the bathroom, where humidity is high. Like all medications, it is crucial to keep Horizant out of the reach of children and pets to prevent accidental ingestion. Check the expiration date and safely discard any unused, expired medicine.
Before taking Horizant, you should tell your doctor about your complete medical history. Be sure to mention any kidney problems, mental health issues like depression or suicidal thoughts, or a history of substance abuse. Also, provide a full list of all other medications you take, including prescription drugs, over-the-counter medicines, and herbal supplements. This information is vital for your doctor to determine if Horizant is safe for you.
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