Glyxambi ^*

This text is for informational purposes only. Please consult your doctor or pharmacist before using any medication.

The most common side effects coming from Glyxambi include:

• Urinary tract infection
• Vaginal yeast infection with symptoms that can include a vaginal odor, white or yellowish vaginal
  discharge, vaginal itching
• Yeast infection of the penis with infection of the glans penis alone or of the glans
  penis and foreskin. Symptoms can include redness, itching, swelling or a rash on the penis, foul-smelling discharge from the penis, and pain in the skin around the penis.
• Upper respiratory tract infection
• Stuffy or runny nose and sore throat
• Increased urination
• Joint pain
• Nausea
• Thirst
• Low blood pressure and fainting caused by dehydration
• Diarrhea
• Cough

If these persist or worsen, consult with a doctor or pharmacist.

Glyxambi may cause the following severe side effects:

• Inflammation of the pancreas (pancreatitis) which may require hospitalization.
• Ketoacidosis (increased levels of ketones in the blood or urine). Ketoacidosis is a serious medical condition that can require treatment in a hospital.
• Dehydration caused by the loss of body fluids and salts may cause dizziness, fainting, or weakness, especially when standing up after sitting down or lying down.
• Low blood sugar level (hypoglycemia) is a common side effect when Glyxambi is being taken along with an additional medicine that can cause low blood sugar levels, such as medicines from the sulfonylurea class or insulin; there is a higher risk of low blood sugar levels.

Stop taking Glyxambi and contact a doctor immediately or go to the nearest emergency room if vomiting, abdominal pain, difficulty breathing, tiredness, or other serious side effects are experienced.

Glyxambi combines empagliflozin and linagliptin to treat type 2 diabetes in adults. Diabetes is diagnosed with a blood test. The main symptoms of type 2 diabetes are:

• Feeling thirsty and needing to urinate frequently; When there is an excess of sugar in the bloodstream, it can cause fluid to be drawn from tissues, leading to increased thirst. This might result in drinking more fluids and urinating more often than usual.
• Increased hunger; In type 2 diabetes, the cells in the body do not respond effectively to insulin, a hormone that helps sugar enter cells for energy. This condition, known as insulin resistance, can create feelings of hunger more often than normal as the body struggles to utilize the energy from food.
• Weight loss; Despite consuming more food to ease hunger pangs, weight loss may occur. Without the ability to use glucose efficiently, the body turns to alternative fuel sources stored in muscles and fat. As a result, excess glucose is eliminated through urine, causing a loss of calories.
• Fatigue; Deprivation of sugar for cells can lead to feelings of tiredness and irritability.
• Blurred vision; Elevated levels of blood sugar can cause swelling in the eye lenses, affecting focus and resulting in blurred vision.
• Delayed wound healing and susceptibility to infections; Type 2 diabetes can impact the body’s ability to heal wounds and fight off infections, particularly affecting areas like gums, skin health and, for women, vaginal infections.

The progression of these symptoms can be gradual, spanning over several years, often making them difficult to detect. It’s not uncommon for individuals with type 2 diabetes to have these symptoms for an extended period without being aware of them.