For visual reference only; actual product may vary
For visual reference only; actual product may vary
Evenity (romosozumab) is a prescription treatment for osteoporosis in postmenopausal women with a high risk for bone fractures. It works by both building new bone and decreasing bone loss to strengthen bones and help prevent fractures. This medication is given as two injections once a month.
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| Evenity Brand | 105mg 2 Pre-Filled Syringes |
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Caution: Evenity carries an FDA black-box warning – the strongest level of safety caution. The warning highlights an increased potential risk of heart attack (myocardial infarction) and stroke in patients with other cardiovascular problems.
This text is for informational purposes only. If there are any questions, discuss these with a healthcare provider or pharmacist before starting treatment. The patient information leaflet that is included with Evenity includes full information about the correct usage, storage and possible side effects. Be sure to read and understand these, and if there are any questions, discuss these with a healthcare provider or pharmacist before starting any other medical treatments or procedures.
Caution: If a sudden allergic reaction (anaphylaxis) occurs shortly after receiving a dose of Evenity, with symptoms like swelling of the face, tongue, or throat making it difficult to breathe or swallow, or there is wheezing, hives, rash, blistering, or peeling of the skin, call a doctor or 911 right away, or go to an emergency room immediately.
Most people who use Evenity do not experience any prolonged side effects.
Known common side effects:
The most common side effects associated with Evenity treatment include joint pain and headaches. Other side effects have been reported less frequently, including:
These symptoms should decrease over time.
Serious side effects requiring medical attention:
Evenity may cause more serious side effects. Treatment carries an increased risk of a cardiovascular event (heart attack or stroke – see the boxed warning). Seek emergency medical help if you experience:
Other serious side effects can occur. Contact your doctor immediately if you have signs of:
Not all the known side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.
Evenity is a preventative treatment for osteoporosis in women after menopause. It is specifically for those who are at a high risk of bone fracture.
Osteoporosis is a condition where the body loses bone mass faster than it can be replaced. This leads to weak, brittle bones that can break easily. It is very common in women after menopause. Evenity helps by not only slowing down bone loss but also by actively building new bone to reduce the risk of fractures.
Evenity begins to increase bone formation shortly after you receive your first dose. Patients can see significant improvements in bone mineral density within the first few months. However, the full benefits of the treatment are realized after completing the entire 12-month course. The goal is to strengthen your bones over this period to provide long-term protection against fractures. Your doctor will monitor your progress throughout the treatment cycle.
Evenity must be administered by a healthcare professional. It is given as two subcutaneous injections, one right after the other, to provide the full monthly dose. You cannot give these injections to yourself at home. They will be administered at your doctor’s office or another clinical setting. This ensures the medication is given correctly and safely every time you receive your monthly treatment.
Evenity requires a consistent monthly dosing schedule for the best results. If you miss a scheduled appointment for your Evenity injections, you should contact your healthcare provider as soon as possible to reschedule. They will help you get your next dose and adjust the schedule for future doses. Do not wait for your next regularly scheduled appointment, as this could reduce the treatment's effectiveness over time.
Evenity treatment works best when your body has enough calcium and vitamin D. Your doctor will instruct you to take daily supplements of both calcium and vitamin D throughout your 12-month treatment course. These nutrients are essential building blocks for forming new, strong bone tissue. Insufficient levels can limit the effectiveness of the medication. Follow your doctor's recommendation for specific supplement dosages.
Evenity could potentially harm an unborn baby and it is not known if it passes into breast milk. You should not use Evenity if you are pregnant, planning to become pregnant, or are currently breastfeeding. It is important to discuss your family planning and health status with your doctor before starting this treatment. They can advise you on the best course of action for your osteoporosis.
Evenity has been linked to a rare but serious jaw problem called osteonecrosis of the jaw (ONJ). For this reason, it is crucial that you inform your dentist that you are being treated with Evenity before any dental procedures. It is also recommended to practice good oral hygiene, including regular brushing, flossing, and dental check-ups, to help minimize your risk while on this medication.
Evenity must be kept refrigerated at a temperature of 36°F to 46°F (2°C to 8°C). It should be stored in its original carton to protect it from light. Do not freeze or shake the medication. Before an injection, the carton can be left at room temperature for at least 30 minutes to make the injection more comfortable, but it should not be left out for more than 30 days.
After you complete your 12-month Evenity treatment course, your doctor will transition you to a different type of osteoporosis medication. This is usually an anti-resorptive drug, which helps maintain the new bone density you have gained and prevents future bone loss. Evenity builds the bone, and the next medication helps to preserve it. This follow-up treatment is a critical step in a long-term strategy to manage osteoporosis.
Evenity should not be given to patients who currently have low blood calcium, a condition known as hypocalcemia. Before you start your treatment, your doctor will test your blood to ensure your calcium levels are normal. They must correct any low calcium levels before your first injection. You will also be advised to take calcium and vitamin D supplements during your treatment to prevent this issue.
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