This text is for informational purposes only. Please consult your doctor or pharmacist before using any medication.

Please read the manufacturer’s Product Insert that comes with the medication. 

The most common side effects of Entresto are:

• hypotension (low blood pressure), which can cause symptoms of dizziness and light-headedness when switching from sitting or lying to standing position
• high levels of potassium in the blood (hyperkalaemia), shown in a blood test
• renal impairment (decreased kidney function)
• cough
• diarrhoea
• anemia
• tiredness
• renal failure
• headache
• syncope (fainting)
• weakness
• nausea
• gastritis (stomach pain, nausea)
• vertigo (spinning sensation)
• low levels of blood sugar (hypoglycaemia.)

Not all side effects can be listed here. Consult a healthcare provider if these or other unexpected effects persist or worsen.

Some side effects can be serious. If you notice swelling of the face, lips, tongue and/or throat, which may cause difficulties in breathing or swallowing, these may be signs of an allergic reaction to one of the components of the medication. Go immediately to an emergency room and take with the box of Entresto.

Heart failure occurs when the heart is weak and cannot pump enough oxygenated blood from the lungs to the rest of the body. In the more severe form (HFrEF), patients typically exhibit symptoms such as shortness of breath, fatigue, reduced exercise tolerance, edema (fluid retention), and rapid heartbeat. Patients with the milder form of heart failure (HFpEF) can experience some of the same symptoms but may have better exercise capacity. They may also be more prone to develop breathing-related (pulmonary) symptoms such as a cough or breathlessness when resting.

Entresto is recommended as a first-line treatment for patients with heart failure with an ejection fraction lower than 45% (classified as HFrEF). Entresto may also be considered as a treatment option for a patient with HFpEF (ejection fraction >45% and < 55%). It is preferred over standard ACEi (angiotensin-converting enzyme inhibitor) and ARB medications.