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  • US Name:


  • Israeli Names:


  • Active Ingredients:

    Sacubitril, Valsartan

  • Brand Manufacturer:


  • Manufacturer Location:



Entresto is used to treat heart failure.

BrandEntresto 200mg (97/103) 56 Tablets 32621 Novartis 1431
BrandEntresto100mg (49/51) 28 Tablets 32619Novartis 1430
BrandEntresto100mg (49/51) 56 Tablets32620 Novartis1432
BrandEntresto 50mg (24/26) 28 Tablets 32618 Novartis 1429

Entresto contains a combination of sacubitril and valsartan. Sacubitril is a blood pressure medicine. It works by increasing the levels of certain proteins in the body that can dilate (widen) blood vessels. This helps lower blood pressure by reducing sodium levels. Valsartan is an angiotensin II receptor blocker (sometimes called an ARB). Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Entresto is used in certain people with chronic heart failure. This medicine helps lower the risk of needing to be hospitalized when symptoms get worse, and helps lower the risk of death from heart failure. Entresto is usually given together with other blood pressure medications..

More common Abdominal or stomach pain blurred vision confusion difficult breathing dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position irregular heartbeat nausea or vomiting nervousness numbness or tingling in the hands, feet, or lips sweating unusual tiredness or weakness weakness or heaviness of the legs Less common Bloody urine decreased frequency or amount of urine increased thirst loss of appetite lower back or side pain swelling of the face, fingers, or lower legs weight gain Rare Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs Some of the side effects that can occur with sacubitril / valsartan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional: More common Cough dizziness

Tell your doctor about all your current medicines and any you start or stop using, especially: aliskiren; lithium; any other heart or blood pressure medicines; a diuretic or “water pill”; medicine or mineral supplements that contain potassium; or NSAIDs (nonsteroidal anti-inflammatory drugs) – aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.


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