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For visual reference only; actual product may vary

  • US Name:

    Comtan

  • Alternative Names:

    Comtan

  • Active Ingredients:

    Entacapone

  • Brand Manufacturer:

    Novartis

  • Manufacturer Location:

    Finland

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  • Click here to view Product Insert

Comtan *

For visual reference only; actual product may vary

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Comtan (Entacapone) is a prescription medication used with levodopa/carbidopa to treat Parkinson’s disease. It helps manage motor symptoms by extending the effectiveness of levodopa, reducing “wearing-off” periods between doses and helping to stabilize dopamine levels in the brain, leading to improved motor function.

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Comtan Brand 200mg
30 Tablets
-
+
Our price:
$72.00

*Please note all prices are in US dollars

What is Comtan?

Comtan is a brand-name prescription medication, with the active ingredient entacapone, used to treat Parkinson’s disease. It is prescribed as an adjunctive therapy, meaning it is taken alongside carbidopa-levodopa to help manage the motor symptoms of Parkinson’s, particularly the “wearing-off” phenomenon that can occur between doses. Comtan is not a standalone treatment but works to enhance the effectiveness of levodopa.

How does Comtan work?

Comtan works by inhibiting an enzyme in the body called catechol-O-methyltransferase (COMT). This enzyme is responsible for breaking down levodopa in the bloodstream before it can reach the brain. By blocking the COMT enzyme, entacapone allows more levodopa to remain in the system, cross the blood-brain barrier, and be converted into dopamine. This process extends the period of time that levodopa is active in the brain, prolonging the relief from Parkinson’s symptoms like tremors, stiffness, and slowness of movement.

Who is Comtan for?

Comtan is intended for patients with Parkinson’s disease who are currently being treated with carbidopa-levodopa but are experiencing end-of-dose “wearing-off” periods. This “wearing-off” refers to the return of motor symptoms before the next scheduled dose of medication is due. If your medication’s effects are not lasting long enough, your doctor may prescribe Comtan to help provide a more consistent and stable level of symptom control throughout the day.

Dosage and administration

Your doctor will determine the appropriate dosage of Comtan for your specific needs. Typically, Comtan is taken as a tablet at the same time as each scheduled dose of carbidopa-levodopa, up to a maximum recommended frequency. It is important to follow your doctor’s instructions precisely and not to adjust the dose on your own. Comtan can be taken with or without food, but taking it consistently will help maintain its effectiveness.

Side effects

Like all medications, Comtan may cause side effects, though not everyone will experience them. The most common side effects include dizziness, nausea, uncontrolled movements (dyskinesia), and a harmless brownish-orange discoloration of the urine. Other potential side effects are diarrhea, abdominal pain, and dry mouth. It is important to stand up slowly to reduce the risk of dizziness. More serious but rare side effects can occur, including hallucinations or an allergic reaction. Contact your healthcare provider immediately if you experience any persistent or concerning symptoms.

Why buy from IsraelPharm?

IsraelPharm offers a convenient and affordable way to purchase your prescription medications like Comtan from a licensed pharmacy. We provide access to brand-name drugs at competitive prices, shipping them directly to your door. Our process is simple and secure, ensuring you receive authentic medication managed by a team of qualified pharmacy professionals. By choosing IsraelPharm, you prioritize both your health and your budget, avoiding high local costs without sacrificing quality or safety.

Most people taking Comtan do not experience serious side effects. However, it’s important to be aware of potential reactions.

Common Side Effects:

  • Nausea, diarrhea, or abdominal pain
  • Dyskinesia (uncontrolled or involuntary movements)
  • Dizziness or lightheadedness, especially when standing up
  • A harmless brownish-orange discoloration of the urine
  • Dry mouth or increased sweating
  • Drowsiness or fatigue

Serious Side Effects:

Contact your doctor immediately if you experience any of the following:

  • Severe diarrhea
  • Hallucinations or unusual, strong urges (such as gambling or spending)
  • Fainting or severe dizziness
  • Unexplained muscle pain, tenderness, or weakness
  • Signs of an allergic reaction (rash, itching, swelling, severe dizziness, trouble breathing)

Comtan (Entacapone) is used for the treatment of Parkinson’s disease. It is specifically indicated for patients who are already taking carbidopa and levodopa preparations and are experiencing signs and symptoms of end-of-dose “wearing-off.” Its primary purpose is to:

  • Reduce “off” time (periods when medication is not working well).
  • Increase “on” time (periods when symptoms are well-controlled).
  • Enhance the overall effectiveness of levodopa therapy.

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