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For visual reference only; actual product may vary
US Name:
Circadin
Alternative Names:
Circadin
Active Ingredients:
Melatonin
Brand Manufacturer:
Neurim
Manufacturer Location:
Israel
Click here to view Product Insert
Click here to view Product Insert
For visual reference only; actual product may vary
Circadin contains melatonin in a prolonged-release formula designed to treat primary insomnia, especially in adults over 55. It helps regulate your natural sleep-wake cycle, improving sleep quality and morning alertness. Order Circadin to help reset your internal body clock and manage sleep disturbances.
| Circadin Brand | 2mg 30 Tablets |
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Our price: $64.00 |
Sleep Pack | 30 Pouches 1 Pouch a Day | –+ | Our price: $50.15 |
Circadin is a prescription medication containing prolonged-release melatonin, used primarily to treat insomnia. Unlike standard over-the-counter melatonin supplements that release the hormone all at once, Circadin is specially formulated to release its active ingredient slowly over 8-10 hours. This mimics the body’s natural melatonin production, helping you not only fall asleep but also stay asleep, leading to better sleep quality and improved morning alertness. It is particularly effective for adults aged 55 and over who experience poor sleep quality.
Circadin works by supplementing your body’s natural melatonin levels, helping to regulate the circadian rhythm, which is your internal 24-hour sleep-wake cycle. The hormone melatonin is naturally produced by the pineal gland in the brain in response to darkness. As levels rise in the evening, they signal to the body that it is time to sleep. Circadin’s prolonged-release mechanism ensures that melatonin levels remain elevated throughout the night, helping to consolidate sleep and prevent waking up too early.
Circadin is primarily intended for adults aged 55 and over who are diagnosed with primary insomnia, which is difficulty sleeping that is not caused by another medical condition or medication. Doctors may also prescribe Circadin off-label for other conditions where the sleep-wake cycle is disrupted. This includes individuals experiencing jet lag, shift workers with irregular schedules, and blind people who lack the light cues necessary for natural melatonin regulation. It can also be an option for those seeking to improve their overall sleep quality and duration under a doctor’s guidance.
The standard dosage for Circadin is one 2mg tablet taken daily, one to two hours before bedtime and after food. It is crucial to swallow the tablet whole, as crushing or chewing it will damage the prolonged-release coating, causing the full dose to be released at once. For best results, you should take it at approximately the same time each evening to help regulate your sleep cycle. Treatment is typically for a short-term period, such as up to 13 weeks. Always follow the specific dosage and duration instructions provided by your prescribing doctor.
While many users experience no side effects, Circadin can cause mild issues like headaches, drowsiness, dizziness, or nausea. Most of these effects are temporary and lessen as your body adjusts to the medication. Less common side effects can include irritability, strange dreams, night sweats, and dry mouth. In rare instances, more serious side effects like feelings of depression, blurred vision, or vertigo can occur. If you experience any severe or persistent side effects, or signs of an allergic reaction like a rash or swelling, you should seek medical attention immediately.
Buying from IsraelPharm provides a reliable and affordable way to access genuine Circadin, which is a prescription-only medication in many countries to ensure quality and potency. While melatonin is sold as an unregulated dietary supplement in the US, our Circadin is a pharmacy-grade product sourced from licensed distributors. We offer significant cost savings, professional pharmacist oversight, and convenient international shipping, ensuring you receive authentic, high-quality medication delivered directly to your door. Trust IsraelPharm for your prescription needs and experience the benefits of a regulated and effective sleep aid.
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Most people who take Circadin do not experience side effects. However, some mild side effects can occur. You should speak to your doctor if they persist or worsen.
Common side effects may include:
Rare but more serious side effects require immediate medical attention:
In very rare cases, a severe allergic (anaphylactic) reaction can occur. Seek emergency medical help for:
This is not a complete list. Always read the patient information leaflet included with your medication.
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Circadin is primarily used to treat primary insomnia (insomnia without an underlying cause) particularly in adults aged 55 and over. It works by regulating the body’s sleep-wake cycle.
Due to its effect on the circadian clock, doctors may also prescribe Circadin off-label for other conditions, including:
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Circadin is a prolonged-release formula that gradually releases melatonin over 8-10 hours, mimicking the body's natural secretion pattern to help you stay asleep. Regular melatonin supplements provide a quick, single dose that may help you fall asleep but might not last through the night.
You should take Circadin one to two hours before your desired bedtime. Most users begin to feel its effects within that timeframe. For best results in regulating your sleep cycle, it is important to take it consistently at the same time each evening after you have eaten.
Yes, Circadin is designed for short-term daily use, typically for a period of up to 13 weeks. It is not considered addictive. However, you should always follow your doctor's instructions regarding the duration of treatment. Long-term use should be discussed with your healthcare provider.
Yes, it is recommended to take your Circadin tablet after you have eaten a meal. Taking it on an empty stomach may alter its effectiveness and how its prolonged-release mechanism works. For best results, take it 1-2 hours before your intended bedtime, after your evening meal.
It is best to avoid alcohol when taking Circadin. Alcohol can interfere with sleep and may reduce the effectiveness of the medication. Combining the two can also increase drowsiness and dizziness, potentially impairing your coordination and judgment, especially the following day. Consult your doctor for personalized advice.
If you forget to take your dose before bed, do not take it in the middle of the night or the next morning, as it could cause significant daytime drowsiness. Simply skip the missed dose and resume your regular schedule by taking the next dose at the usual time in the evening.
Circadin can cause drowsiness that may carry over to the next day for some individuals. You should assess how you feel before driving or operating heavy machinery. It is best to avoid these activities until you are confident that you are fully alert and the medication's effects have worn off.
No, you must swallow the Circadin tablet whole. It is a prolonged-release tablet, and cutting, crushing, or chewing it will destroy the special coating. This would cause the entire dose of melatonin to be released at once, undermining its intended effect and potentially increasing side effects.
Yes, Circadin may interact with several medications. Inform your doctor if you take fluvoxamine, cimetidine, estrogens, psoriasis medications, warfarin, or benzodiazepines. These can affect how Circadin works or increase the risk of side effects. Always provide a full list of your current medications to your doctor.
While officially approved for insomnia, doctors often prescribe Circadin off-label to help manage jet lag. By taking it at the target bedtime of your new time zone, it can help reset your internal body clock more quickly, reducing the fatigue and sleep disturbances associated with long-distance travel.
The most frequently reported side effects are generally mild and may include headache, nasopharyngitis (cold-like symptoms), back pain, and joint pain. Some people may also experience daytime drowsiness, dizziness, or nausea. These effects often lessen as your body adjusts to the medication over time.
Store Circadin tablets at room temperature, below 25°C (77°F), in their original carton to protect them from light. Keep the medication in a dry place and safely out of the reach of children and pets. Do not use the tablets after the expiration date printed on the package.
Caution is advised for individuals with autoimmune diseases like rheumatoid arthritis or lupus, as melatonin can influence the immune system. It is essential to consult your doctor before starting Circadin. They can help you weigh the potential benefits against the risks based on your specific health condition.
Because Circadin is a prolonged-release formula designed to work throughout the night, some individuals might feel groggy upon waking, particularly when first starting. This effect usually diminishes over time. Taking the tablet at the recommended time, 1-2 hours before bed, can help minimize this feeling.
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IsraelPharm has been delivering lost cost prescriptions from Israel for over 15 years worldwide. Daily flights allow us to get your medications dispatched fast! Delivery to the USA is under 10 days and you can track and trace every order.


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