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For visual reference only; actual product may vary
For visual reference only; actual product may vary
Cerdelga (Eliglustat) is a prescription oral therapy for adults with type 1 Gaucher disease. It helps manage the condition by reducing the production of fatty substances that accumulate in your organs. Your suitability for treatment is determined by a specific genetic test (CYP2D6 metabolizer status).
| Cerdelga Brand | 84mg 56 Capsules |
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Our price: $34,500.00 |
Cerdelga is a prescription oral medication, with the active ingredient eliglustat, used for the long-term treatment of adults diagnosed with Gaucher disease type 1. Unlike treatments that are given by infusion, Cerdelga is a capsule that you can take by mouth. It is specifically intended for patients whose genetic makeup identifies them as CYP2D6 poor, intermediate, or extensive metabolizers, which a doctor can determine through a simple test. This medication helps manage the symptoms of Gaucher disease by addressing its underlying cause at a chemical level.
Cerdelga works by inhibiting an enzyme in your body called glucosylceramide synthase. In people with Gaucher disease, a different enzyme that breaks down a fatty substance (lipid) called glucosylceramide doesn’t work correctly. This causes the lipid to build up in organs like the spleen, liver, and bone marrow, leading to the signs and symptoms of the disease. By blocking glucosylceramide synthase, Cerdelga reduces the amount of this fatty substance your body produces in the first place, preventing its harmful accumulation and helping to shrink enlarged organs and improve blood counts.
Cerdelga is for adults who have a confirmed diagnosis of type 1 Gaucher disease and have been identified through genetic testing as a suitable CYP2D6 metabolizer. Gaucher disease is a genetic disorder, and treatment with Cerdelga is highly personalized. Your doctor will perform a test to see how your body processes certain drugs through the CYP2D6 pathway. This determines if Cerdelga is a safe and effective option for you, and it also dictates the correct dosage. It is not intended for children, pregnant or breastfeeding women, or patients who are classified as “ultra-rapid metabolizers” via the CYP2D6 test.
The correct dosage of Cerdelga is determined by your doctor based on your specific genetic profile, particularly your CYP2D6 metabolizer status, and whether you are taking other medications. Cerdelga is taken orally, typically twice a day, with or without food. It is crucial to take the capsules whole and not to crush, chew, or dissolve them. Consistency is key, so you should take your dose at the same times each day. If you miss a dose, you should not double up; simply take your next dose at its scheduled time. Always follow your healthcare provider’s instructions precisely for the best results.
Like any medication, Cerdelga may cause side effects, though not everyone experiences them. The most common side effects include fatigue, headache, nausea, diarrhea, and pain in the back, joints, or limbs. Some people may also experience upper abdominal pain. More serious side effects can occur, including effects on the heart’s rhythm. Your doctor will likely perform an electrocardiogram (ECG) before and during your treatment to monitor your heart. It’s important to tell your doctor about all of your medical conditions and any other medications you are taking before starting Cerdelga.
Choosing IsraelPharm for your Cerdelga prescription provides a seamless and affordable path to managing your condition. We are staffed by licensed pharmacists who can answer your questions and ensure you feel confident about your treatment. By sourcing medication from a network of international suppliers, we can offer competitive pricing that helps reduce your financial burden. We provide reliable, discreet shipping directly to your door, combining the convenience of online ordering with the assurance of professional pharmaceutical care. Trust us to be your partner in long-term health management.
Patients taking Cerdelga may experience side effects. It is important to discuss these potential effects with your doctor.
Common side effects may include:
Serious side effects can occur, including:
Contact your healthcare provider if you experience any severe or concerning side effects, such as dizziness, fainting, or heart palpitations.
Cerdelga (eliglustat) is an oral prescription medication indicated for the long-term treatment of adult patients with Gaucher disease type 1. Its use is specifically approved for patients who fall into one of the following CYP2D6 metabolizer genotypes:
Cerdelga helps to reduce the accumulation of glucosylceramide, thereby alleviating symptoms such as enlarged spleen and liver, anemia, and bone problems.
If you miss a dose of Cerdelga, do not take an extra dose to make up for it. Simply skip the missed dose and take your next dose at the regularly scheduled time. Doubling up on doses can increase your risk of side effects. Maintaining a consistent schedule is important for the medication to work effectively, so try to take it at the same times each day.
The timeframe for seeing improvements with Cerdelga can vary from person to person. Some patients may notice a reduction in symptoms like fatigue or an improvement in blood counts within a few months. However, more significant changes, such as the reduction in the size of the liver and spleen, can take six months to a year or longer. Consistent, long-term use is key to managing Gaucher disease effectively.
A CYP2D6 metabolizer test is a genetic test that determines how your body processes certain medications, including Cerdelga. The CYP2D6 enzyme helps break down drugs, and your genes determine how active this enzyme is. Your test result will classify you as a poor, intermediate, extensive, or ultra-rapid metabolizer. This is crucial for Cerdelga, as it is not for ultra-rapid metabolizers and the dose depends on your specific type.
Cerdelga is not a cure for Gaucher disease, which is a lifelong genetic condition. Instead, it is a long-term treatment designed to manage the disease effectively. It works by reducing the buildup of the harmful fatty substance that causes symptoms. By taking Cerdelga continuously as prescribed by your doctor, you can manage symptoms, prevent complications, and maintain a better quality of life.
You should discuss your alcohol consumption with your doctor before starting Cerdelga. Both alcohol and Cerdelga are processed by the liver. Consuming alcohol, especially in large amounts, could potentially put extra strain on your liver. Your doctor can provide personalized advice based on your overall health, liver function, and specific circumstances to ensure your safety during treatment.
Yes. Grapefruit and grapefruit juice can increase the level of Cerdelga in your blood and should be avoided. Also, many other prescription and over-the-counter medications can interact with Cerdelga by affecting the CYP2D6 and CYP3A enzymes. It is critical to provide your doctor with a complete list of all medications, supplements, and herbal products you are taking to prevent harmful interactions.
Cerdelga should be stored at room temperature, between 68°F to 77°F (20°C to 25°C). Keep the capsules in their original container, tightly closed, and in a dry place away from moisture and direct heat or sunlight. As with all medications, it is important to keep Cerdelga out of the reach of children and pets to prevent accidental ingestion.
Yes, Cerdelga is convenient in that it can be taken with or without food. This gives you flexibility in fitting it into your daily routine. The most important factor is consistency, so you should aim to take your doses at approximately the same time each day, regardless of your meal schedule. Always swallow the capsule whole with a glass of water.
Yes, Cerdelga can affect the heart's electrical activity in some people, a condition known as QTc prolongation, which can lead to an irregular heartbeat. For this reason, your doctor will likely perform an ECG to check your heart's rhythm before you start and periodically during your treatment. It’s important to inform your doctor if you have any history of heart problems.
No, Cerdelga is not chemotherapy. It is a type of treatment called substrate reduction therapy (SRT). While chemotherapy is designed to kill cancer cells, Cerdelga works by reducing the production of a specific fatty substance (glucosylceramide) that builds up in patients with Gaucher disease. It targets the underlying metabolic issue of the disease, not cancer cells.
Cerdelga is generally not recommended for women who are pregnant or planning to become pregnant. Studies in animals have suggested potential risk to a developing fetus. If you are taking Cerdelga and become pregnant or wish to conceive, you must speak with your doctor immediately to discuss the potential risks and decide on the best course of action for managing your Gaucher disease during pregnancy.
No, Cerdelga is a different type of treatment called substrate reduction therapy (SRT). Enzyme replacement therapy (ERT) works by administering a functional version of the enzyme that is missing in Gaucher disease, typically through infusions. Cerdelga, an oral capsule, works by reducing the production of the substance that the enzyme is supposed to break down. It's an alternative approach to managing the same problem.
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