For visual reference only; actual product may vary
For visual reference only; actual product may vary
Austedo (deutetrabenazine) is a prescription medication designed to control involuntary movements in adults with chorea from Huntington’s disease or tardive dyskinesia. It works by adjusting dopamine levels in the brain to reduce unwanted, repetitive motions and improve quality of life for patients with these conditions.
| Austedo Brand | 12mg 60 Tablets |
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Our price: $10,363.00 |
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| Austedo Brand | 9mg 60 Tablets |
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Our price: $7,772.00 |
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| Austedo Brand | 6mg 60 Tablets |
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Our price: $6,909.00 |
Austedo is a brand-name prescription medication, with the active ingredient deutetrabenazine, used to manage involuntary movements in adults. It is specifically approved to treat two conditions: chorea, the irregular, jerky movements associated with Huntington’s disease, and tardive dyskinesia (TD), which involves repetitive, involuntary movements often caused by long-term use of certain psychiatric medications. Austedo belongs to a class of drugs called vesicular monoamine transporter 2 (VMAT2) inhibitors, which target a key protein involved in nerve signaling.
Austedo works by reducing the amount of dopamine released in the brain, which helps to control involuntary movements. Its active ingredient, deutetrabenazine, inhibits a protein called VMAT2, which is responsible for transporting chemical messengers like dopamine into storage vesicles within nerve cells. By limiting this process, Austedo decreases the amount of dopamine available for release at the nerve synapse, thus dampening the excessive signaling that causes the involuntary movements of chorea and tardive dyskinesia. This specific mechanism helps restore more controlled motor function.
Austedo is for adults diagnosed with chorea associated with Huntington’s disease or tardive dyskinesia (TD). Patients with Huntington’s who experience disruptive, dance-like movements that interfere with daily activities like walking, talking, and eating may be candidates for this treatment. It is also prescribed for individuals who have developed TD, characterized by repetitive facial tics (like lip-smacking or grimacing) or limb movements, as a side effect of other medications, typically antipsychotics. The decision to use Austedo is made by a healthcare provider after a thorough evaluation.
Dosage of Austedo is personalized and gradually increased by a healthcare provider to find the most effective and tolerable dose for the patient. A typical starting dose is 6 mg taken twice daily, for a total of 12 mg per day. Depending on the patient’s response and any side effects, the doctor may increase this amount in weekly intervals of 6 mg per day. The maximum recommended daily dosage is 48 mg. For optimal absorption, Austedo tablets should always be taken with food. The extended-release tablets must be swallowed whole and should not be crushed, chewed, or broken.
Common side effects of Austedo can include sleepiness, diarrhea, dry mouth, and fatigue, though not everyone experiences them. A critical warning for this medication is the increased risk of depression and suicidal thoughts, particularly in patients with Huntington’s disease. Due to this risk, the FDA requires a boxed warning on its label. Patients and their families must monitor for any signs of worsening depression or thoughts of self-harm and report them to a doctor immediately. In rare cases, a serious condition with symptoms like high fever, stiff muscles, and a rapid heartbeat can occur, requiring urgent medical attention.
Purchasing your medication from IsraelPharm ensures you receive genuine Austedo at a competitive price, shipped directly to your door with reliability and care. We are a licensed pharmacy committed to providing safe, affordable access to brand-name medications from trusted manufacturers. Our streamlined online ordering process, dedicated customer support team, and global shipping capabilities make managing your prescription simple and convenient. By choosing IsraelPharm, you prioritize both your health and your budget without compromising on quality or service.
Boxed Warning: Austedo carries a warning for an increased risk of depression and suicidal thoughts, especially in patients with Huntington’s disease. Monitor for mood changes and contact a doctor immediately if such symptoms occur.
Common side effects may include:
Contact your doctor if you experience a high fever, muscle stiffness, or a fast, irregular heartbeat, as these may be signs of a serious condition. This is not a complete list of side effects.
Austedo is FDA-approved for the treatment of:
It is also being investigated for off-label use in treating Tourette syndrome.
Austedo is a prescription medicine used to treat adults with two specific movement disorders. It helps control the involuntary, jerky, dance-like movements (chorea) associated with Huntington's disease. It is also used to treat tardive dyskinesia (TD), which involves repetitive, involuntary movements of the face, tongue, or limbs often caused by other medications.
The time it takes for Austedo to show a noticeable effect can vary between individuals. Your doctor will start you on a low dose and increase it gradually over several weeks. This titration period allows your body to adjust and helps find the optimal dose for you. Some patients may begin to see improvements in their movements within a few weeks of reaching a stable, therapeutic dose.
Austedo contains deutetrabenazine, which is a modified version of tetrabenazine. This modification, known as deuteration, slows down the drug's metabolism in the body. As a result, Austedo can be taken less frequently (typically twice a day) and provides more stable drug levels in the bloodstream. This may lead to fewer and less severe side effects compared to tetrabenazine for some patients.
Yes, it is very important to take Austedo with food. Taking your dose with a meal helps your body absorb the medication properly, ensuring you get the full and intended therapeutic effect. The prescribing instructions specify that tablets should always be taken with food. Do not crush or chew the tablets; they must be swallowed whole.
If you miss a dose of Austedo, you should take it as soon as you remember, as long as it is with food. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at the same time to make up for a missed one. If you are unsure what to do, consult your doctor or pharmacist.
You should be cautious about drinking alcohol while taking Austedo. Both alcohol and Austedo can cause drowsiness and sedation. Combining them may intensify these effects, which could impair your coordination and judgment, making activities like driving unsafe. It is best to discuss your alcohol consumption with your doctor before starting this medication to understand the potential risks.
The most common side effects of Austedo can differ slightly depending on the condition being treated. For Huntington's disease chorea, they include sleepiness, diarrhea, dry mouth, and fatigue. For tardive dyskinesia, common side effects are inflammation of the nose and throat (nasopharyngitis) and difficulty sleeping (insomnia). Most people do not experience severe side effects.
Austedo has a 'boxed warning,' which is the FDA's most serious type of warning. It alerts doctors and patients to an increased risk of depression and suicidal thoughts or actions, particularly in patients with Huntington's disease who are already at a higher risk. It is crucial for patients and their families to monitor for any new or worsening signs of depression and report them to a healthcare provider immediately.
You should store Austedo tablets in their original bottle at a controlled room temperature, between 68°F to 77°F (20°C to 25°C). Keep the bottle tightly closed to protect the medication from moisture and light. Each bottle contains a desiccant pack to absorb moisture; do not remove this pack from the bottle.
Austedo is sometimes prescribed 'off-label' to treat tics associated with Tourette syndrome, although this is not an FDA-approved use. The decision to use Austedo for Tourette's is based on a doctor's professional judgment that the potential benefits outweigh the risks for a specific patient. Clinical studies are ongoing to further evaluate its effectiveness for this condition.
You should not stop taking Austedo suddenly without first talking to your healthcare provider. Abruptly stopping the medication could potentially lead to a worsening of your symptoms or other withdrawal-like effects. If you and your doctor decide to discontinue treatment, your doctor will likely recommend a plan to gradually reduce your dose to do so safely.
Yes, drowsiness or sleepiness is a common side effect of Austedo. Because of this, you should be cautious when performing activities that require mental alertness, such as driving a car or operating heavy machinery, until you know how the medication affects you. This effect may be more pronounced when you first start taking the drug or after a dose increase.
The dose of Austedo is highly individualized. Your doctor will start you on a low dose and then slowly increase it each week. This process, called titration, allows your doctor to find the lowest effective dose that controls your symptoms while minimizing potential side effects. The final daily dose will depend on your specific response and tolerance to the medication, up to a maximum of 48 mg per day.
No, Austedo is not a cure for Huntington's disease or tardive dyskinesia. It is a treatment designed to manage the symptoms of these conditions, specifically the involuntary movements. While it can significantly improve a person's quality of life by reducing the severity of chorea or TD, it does not stop the progression of the underlying disease.
Before starting Austedo, tell your doctor about your complete medical history. It's especially important to mention if you have liver problems, a heart condition like Long QT syndrome, or a history of depression or suicidal thoughts. Also, provide a list of all other medications you take, including prescription drugs, over-the-counter medicines, and supplements, to avoid potential drug interactions.
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