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For visual reference only; actual product may vary

  • US Name:

    Afinitor

  • Alternative Names:

    Afinitor

  • Active Ingredients:

    Everolimus

  • Brand Manufacturer:

    Novartis

  • Manufacturer Location:

    Switzerland

  • Click here to view Product Insert

  • Click here to view Product Insert

Afinitor *

For visual reference only; actual product may vary

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Afinitor (everolimus) is a targeted therapy medication used to treat several types of advanced cancer, including breast, kidney, and pancreatic tumors. It functions as an mTOR inhibitor, working to slow or stop the growth and spread of cancer cells. It may be prescribed alone or with other treatments.

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Afinitor Brand 10mg
30 Tablets
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Our price:
$2,357.00
Afinitor Brand 5mg
30 Tablets
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Our price:
$988.00
Afinitor Brand 2.5mg
30 Tablets
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Our price:
$4,099.00

*Please note all prices are in US dollars

What is Afinitor?

Afinitor is a prescription oral medication, with the active ingredient everolimus, used to treat several types of advanced cancers and certain tumors associated with a genetic condition called tuberous sclerosis complex (TSC). It belongs to a class of drugs known as mTOR inhibitors, which are a form of targeted cancer therapy. By focusing on specific pathways that cancer cells use to grow, Afinitor helps to slow or stop their proliferation, offering a modern approach to cancer treatment for patients who meet specific criteria.

How does Afinitor work?

Afinitor works by blocking a specific protein in the body called the “mechanistic target of rapamycin,” or mTOR. This protein acts like a control switch within cells, regulating their growth, division, and survival. In many types of cancer, the mTOR pathway is overactive, which allows cancer cells to multiply uncontrollably. By inhibiting the mTOR protein, Afinitor effectively turns off this growth signal, which can slow the progression of the tumor, prevent the formation of new blood vessels that feed the tumor, and ultimately help manage the disease.

Who is Afinitor for?

Afinitor is intended for adult and sometimes pediatric patients diagnosed with specific types of advanced or progressive diseases. Its use is highly targeted, meaning it is prescribed based on the cancer type, its genetic markers, and what other treatments have already been tried. For example, it’s used for postmenopausal women with advanced hormone receptor-positive, HER2-negative breast cancer, and for patients with advanced neuroendocrine tumors (NET) of the pancreas, lung, or gastrointestinal tract. It is also a treatment option for advanced renal cell carcinoma (kidney cancer) after other therapies have failed, and for certain non-cancerous tumors in patients with tuberous sclerosis complex (TSC).

Dosage and administration

The dosage and administration of Afinitor must be determined by a qualified healthcare provider based on the specific condition being treated, the patient’s overall health, and their response to the medication. The tablets are typically taken orally once a day, at the same time each day, and can be taken either consistently with food or consistently without food. It is crucial to swallow the tablets whole with a glass of water and not to crush or chew them. Your doctor will monitor you closely and may adjust your dose as needed to maximize effectiveness while minimizing side effects.

Side effects

Like most cancer treatments, Afinitor can cause side effects, which range from mild to severe. The most common side effects include mouth sores, rash, feeling weak or tired, nausea, and an increased risk of infections. Your healthcare team will monitor you for these and other potential effects, such as lung or breathing problems, kidney issues, or changes in blood sugar levels. It is very important to communicate openly with your doctor about any symptoms you experience, as many side effects can be managed effectively. In some cases, side effects may be serious and require immediate medical attention.

Why buy from IsraelPharm?

Choosing IsraelPharm to fill your Afinitor prescription provides a safe, reliable, and cost-effective solution for your medication needs. We source our authentic, brand-name medications directly from reputable manufacturers like Novartis, ensuring you receive the same high-quality treatment you would from a local pharmacy. Our streamlined online ordering process is convenient and confidential, with support available from our team of pharmacy experts. By eliminating several layers of the supply chain, we are able to offer competitive prices on essential medications, helping to reduce the financial burden of your cancer treatment journey.

The most common side effects of Afinitor may include:

  • Mouth sores, swelling, or irritation
  • Increased risk of infections
  • Feeling weak or tired
  • Cough and shortness of breath
  • Headache
  • Nausea, diarrhea, and decreased appetite
  • Skin rash and dryness
  • Fever

While less common, Afinitor can also cause serious side effects that require immediate medical attention:

  • Lung or Breathing Problems: New or worsening cough, shortness of breath, chest pain, or wheezing.
  • Serious Infections: Fever, chills, or other signs of infection.
  • Kidney Failure: Reduced or no urination.
  • Impaired Wound Healing: Any surgical wound that is red, warm, swollen, or not healing properly.
  • Severe Allergic Reaction: Hives, difficulty breathing, or swelling of the face, lips, and throat.

Afinitor is prescribed for a range of specific cancers and tumor-related conditions, including:

  • Advanced Breast Cancer: For postmenopausal women with hormone receptor-positive, HER2-negative breast cancer, used in combination with exemestane after treatment with letrozole or anastrozole has not worked.
  • Neuroendocrine Tumors (NET): For progressive NETs that originate in the pancreas (PNET), gastrointestinal (GI) tract, or lungs that cannot be surgically removed or have spread.
  • Renal Cell Carcinoma (RCC): For advanced kidney cancer after treatment with sunitinib or sorafenib has failed.
  • Tuberous Sclerosis Complex (TSC): For treating renal angiomyolipoma (a benign kidney tumor) and for certain types of seizures in adults and children aged 2 and older.

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