Gleevec ^*

Gilvec / Gleevec (generic name: imatinib) is a targeted cancer medication known as a tyrosine kinase inhibitor (TKI). It is used to treat a range of blood cancers and tumours by blocking the action of abnormal proteins that cause cancer cells to grow. Unlike traditional chemotherapy, which affects many types of cells, Gilvec works more selectively, focusing on the exact pathway that drives the cancer. The medicine is approved for treating several conditions. These include:

• Chronic myeloid leukaemia (CML) in adults and children
• Acute lymphoblastic leukaemia (ALL) that is Philadelphia chromosome-positive (Ph+)
• Gastrointestinal stromal tumours (GIST
• Dermatofibrosarcoma protuberans (DFSP).

It also treats certain rare disorders such as hypereosinophilic syndrome (HES), chronic eosinophilic leukaemia, and some forms of myelodysplastic/myeloproliferative diseases. Imatinib works by inhibiting a protein that signals cancer cells to grow and divide. This protein is overactive in patients with the Philadelphia chromosome, a genetic mutation commonly associated with certain types of blood cancer. By switching off this growth signal, the medicine slows the disease and helps restore blood counts to normal levels. Gilvec was one of the first targeted cancer treatments and marked a turning point in how certain cancers are managed. Today, it is widely used worldwide and is included on the World Health Organization’s List of Essential Medicines. It is well studied and has been shown to improve long-term outcomes for many patients. Caution: Unless specifically prescribed, Gilvec should not be taken by preganant or breastfeeding women. Contraception is necessary while taking the medication, and if there are indications of pregnancy, consult a healthcare provider immediately.

Dosage

Follow the instructions printed on the box label. Gilvec is usually taken by mouth once daily, with a meal and a full glass of water. For adult CML in the chronic phase, the standard dose is 400 mg per day. In later stages of leukemia or GIST, doses may increase to 600 mg or 800 mg daily. A daily dose of 800 mg is usually split into 400 mg twice a day. Tablets should be swallowed whole. If swallowing is difficult, tablets can be dissolved in water or apple juice and consumed immediately. If a dose is missed, take it as soon as you remember. However, if it is almost time to take the next dose, do not take the forgotten dose. Continue taking the medicine as per the normal schedule. Do not take a double dose to make up for it. Do not stop taking Gilvec without first consulting a doctor. Treatment usually continues until the doctor determines that the disease is controlled and the side effects are manageable.

Storage

Gilvec tablets should be stored at room temperature, below 25°C (77°F), in their original container to protect them from moisture. Get more advice about safe drug storage.