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For visual reference only; actual product may vary
For visual reference only; actual product may vary
Creon (pancrelipase) is a leading pancreatic enzyme replacement therapy (PERT) for those with Exocrine Pancreatic Insufficiency (EPI). It helps your body absorb nutrients by digesting fats, proteins, and carbohydrates in food. It is essential for managing conditions like cystic fibrosis and chronic pancreatitis.
| Creon Brand | 35,000 Units 100 Capsules |
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Our price: $207.00 |
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| Creon Brand | 25,000 Units 50 Capsules |
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Our price: $68.00 |
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| Creon Brand | 10,000 Units 100 Capsules |
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Our price: $106.00 |
 Gut Pack | 30 Pouches 1 Pouch a Day | –+ | Our price: $70.55 |
Creon is a brand name for pancrelipase, a pancreatic enzyme replacement therapy (PERT) used to treat Exocrine Pancreatic Insufficiency (EPI). EPI occurs when the pancreas fails to produce a sufficient amount of the enzymes needed to digest food, leading to malabsorption of vital nutrients. Creon contains a mixture of digestive enzymes—lipase, amylase, and protease—that help break down fats, carbohydrates, and proteins, respectively. This action mimics the natural function of a healthy pancreas, ensuring your body gets the nourishment it needs from your diet.
Creon works by delivering a concentrated dose of pancreatic enzymes directly to your digestive system. The enzymes in Creon—lipase, protease, and amylase—replace the ones your own pancreas is unable to produce. When you take a capsule with food, it dissolves in your stomach, releasing small, enzyme-filled microspheres. These microspheres mix with the food and travel to the small intestine, where they activate to help digest your meal. This process allows your body to break down and absorb fats, proteins, and carbohydrates, preventing symptoms of maldigestion and improving your nutritional status.
Creon is for children and adults who have Exocrine Pancreatic Insufficiency (EPI). This condition prevents the pancreas from making enough enzymes to digest food effectively and is often associated with other underlying medical issues. It is commonly prescribed for patients with cystic fibrosis, as thick mucus can block the ducts of the pancreas. It is also suitable for individuals with chronic pancreatitis, those who have undergone pancreatic or stomach surgery (pancreatectomy or gastrectomy), and patients with pancreatic cancer that obstructs the pancreatic duct.
Creon should be taken exactly as prescribed by your healthcare provider, with the dosage tailored to your individual needs, body weight, and diet. The capsules must be swallowed whole with a meal or snack and plenty of liquid; they should not be crushed or chewed. For those who cannot swallow capsules, they can be carefully opened and the contents sprinkled onto a small amount of acidic soft food, like applesauce. The dose is based on the lipase units and corresponds to the amount of fat in your diet. Different formulations of Creon are available in the USA and Israel, with varying enzyme unit counts as detailed in our product comparison table. Always follow your doctor’s specific instructions to ensure the best results.
The most common side effects of Creon involve the digestive system, including abdominal pain, gas (flatulence), bloating, nausea, vomiting, and diarrhea or constipation. These effects are often dose-related and may be managed by adjusting your intake. A rare but serious bowel disorder, fibrosing colonopathy, has been reported in patients with cystic fibrosis taking high doses of pancreatic enzymes. If you experience any severe or prolonged stomach pain, it is crucial to contact your doctor immediately. Allergic reactions are also possible but uncommon.
IsraelPharm provides a reliable and cost-effective source for purchasing Creon online. We are committed to offering competitive pricing on authentic, brand-name medications, helping you manage your EPI without the financial strain. Our platform allows you to conveniently order your essential pancreatic enzyme therapy from the comfort of your home. With access to different formulations, including those from the Israeli market, you can find the specific product that meets your needs as determined by your healthcare provider, ensuring continuous and effective treatment.
Like all medications, Creon may cause side effects. Common side effects include:
More serious side effects can occur. Contact your doctor immediately if you experience severe or unusual stomach pain, as this could be a symptom of a rare bowel disorder called fibrosing colonopathy. Seek immediate medical help for signs of an allergic reaction, such as a rash, itching, or difficulty breathing.
Creon is used to treat Exocrine Pancreatic Insufficiency (EPI), a condition where the body does not produce enough enzymes to digest food. It is prescribed for patients with:
If you forget to take Creon with your meal or snack, wait until your next scheduled meal and take your regular dose then. Do not take extra capsules to make up for the missed one. Creon must be taken with food to work effectively, so taking it between meals will not provide any benefit and may increase the risk of side effects.
Yes, if you have trouble swallowing the capsules, they can be carefully opened. Sprinkle the contents (microspheres) on a small amount of acidic soft food like applesauce, yogurt, or pureed pears. Swallow the mixture immediately without chewing, and follow up with a glass of water or juice to ensure all the microspheres are ingested. Never mix it with milk-based foods.
Creon begins to work as soon as it reaches the small intestine and mixes with food. Its effects, such as reduced bloating, gas, and improved stool consistency, can often be noticed within a few days of starting treatment. The primary goal is improved nutrient absorption, which your doctor can monitor through clinical evaluation and blood tests over time.
The main difference between Creon formulations from the USA and Israel lies in the unit measurements for the protease and amylase enzymes. While the lipase units are generally comparable, the Ph.Eur (European Pharmacopoeia) and USP (United States Pharmacopeia) units can differ. It is essential to review the product-specific table and consult your doctor to choose the formulation that matches your prescription.
Alcohol can damage the pancreas and worsen conditions like chronic pancreatitis. While there isn't a direct interaction with Creon itself, drinking alcohol is generally discouraged for individuals with pancreatic insufficiency. It can interfere with your treatment and overall health. Always consult your healthcare provider for personalized advice regarding alcohol consumption and your specific condition.
Creon should be stored in a tightly sealed container at room temperature, ideally between 59°F and 77°F (15°C to 25°C). Keep the capsules away from moisture and high heat, so avoid storing them in bathrooms or kitchens near the stove. Proper storage is important to maintain the effectiveness of the enzymes within the capsules.
Yes, taking a higher dose of Creon than prescribed can lead to side effects or complications. Extremely high doses have been associated with high uric acid levels in the blood (hyperuricemia) and a rare but serious bowel condition called fibrosing colonopathy. Always follow your doctor’s dosing instructions carefully and never adjust the dose on your own.
Creon is generally well-tolerated and doesn't have many major drug interactions. However, it's wise to inform your doctor about all medications you take, including over-the-counter drugs and supplements. For example, antacids containing calcium carbonate or magnesium hydroxide can potentially reduce Creon's effectiveness. Your doctor can manage any potential interactions to ensure your treatment remains effective.
No, Creon does not cure Exocrine Pancreatic Insufficiency (EPI). It is a replacement therapy, not a cure. It works by providing the digestive enzymes your pancreas can no longer produce, allowing you to digest food properly. Treatment with Creon is typically lifelong for chronic conditions, helping you manage symptoms and maintain your nutritional health effectively.
When your Creon dose is optimized, you should notice a significant improvement in digestive symptoms. Key signs include a reduction in bloating, gas, and abdominal pain. You may also see an improvement in bowel movements, with fewer loose, greasy, or foul-smelling stools (steatorrhea). Over time, proper dosage can lead to weight gain or stabilization, indicating better nutrient absorption.
Yes, the pancrelipase in Creon is derived from the pancreases of pigs. The enzymes are purified and processed to be used in medicine. For this reason, you should not take Creon if you have a known allergy to pork or any other ingredient in the medication. Discuss any allergies or dietary restrictions with your healthcare provider before starting treatment.
Your Creon dose is directly linked to the fat content of your meals. Doses are calculated in lipase units, the enzyme that digests fat. Your doctor will determine a starting dose based on your weight and typical diet. You may need to adjust the number of capsules you take with each meal or snack depending on how much fat it contains. Consistent eating habits can help stabilize your dosage.
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