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For visual reference only; actual product may vary
For visual reference only; actual product may vary
Comtan (Entacapone) is a prescription medication used with levodopa/carbidopa to treat Parkinson’s disease. It helps manage motor symptoms by extending the effectiveness of levodopa, reducing “wearing-off” periods between doses and helping to stabilize dopamine levels in the brain, leading to improved motor function.
| Comtan Brand | 200mg 30 Tablets |
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Our price: $72.00 |
Comtan is a brand-name prescription medication, with the active ingredient entacapone, used to treat Parkinson’s disease. It is prescribed as an adjunctive therapy, meaning it is taken alongside carbidopa-levodopa to help manage the motor symptoms of Parkinson’s, particularly the “wearing-off” phenomenon that can occur between doses. Comtan is not a standalone treatment but works to enhance the effectiveness of levodopa.
Comtan works by inhibiting an enzyme in the body called catechol-O-methyltransferase (COMT). This enzyme is responsible for breaking down levodopa in the bloodstream before it can reach the brain. By blocking the COMT enzyme, entacapone allows more levodopa to remain in the system, cross the blood-brain barrier, and be converted into dopamine. This process extends the period of time that levodopa is active in the brain, prolonging the relief from Parkinson’s symptoms like tremors, stiffness, and slowness of movement.
Comtan is intended for patients with Parkinson’s disease who are currently being treated with carbidopa-levodopa but are experiencing end-of-dose “wearing-off” periods. This “wearing-off” refers to the return of motor symptoms before the next scheduled dose of medication is due. If your medication’s effects are not lasting long enough, your doctor may prescribe Comtan to help provide a more consistent and stable level of symptom control throughout the day.
Your doctor will determine the appropriate dosage of Comtan for your specific needs. Typically, Comtan is taken as a tablet at the same time as each scheduled dose of carbidopa-levodopa, up to a maximum recommended frequency. It is important to follow your doctor’s instructions precisely and not to adjust the dose on your own. Comtan can be taken with or without food, but taking it consistently will help maintain its effectiveness.
Like all medications, Comtan may cause side effects, though not everyone will experience them. The most common side effects include dizziness, nausea, uncontrolled movements (dyskinesia), and a harmless brownish-orange discoloration of the urine. Other potential side effects are diarrhea, abdominal pain, and dry mouth. It is important to stand up slowly to reduce the risk of dizziness. More serious but rare side effects can occur, including hallucinations or an allergic reaction. Contact your healthcare provider immediately if you experience any persistent or concerning symptoms.
IsraelPharm offers a convenient and affordable way to purchase your prescription medications like Comtan from a licensed pharmacy. We provide access to brand-name drugs at competitive prices, shipping them directly to your door. Our process is simple and secure, ensuring you receive authentic medication managed by a team of qualified pharmacy professionals. By choosing IsraelPharm, you prioritize both your health and your budget, avoiding high local costs without sacrificing quality or safety.
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Most people taking Comtan do not experience serious side effects. However, it’s important to be aware of potential reactions.
Common Side Effects:
Serious Side Effects:
Contact your doctor immediately if you experience any of the following:
Comtan (Entacapone) is used for the treatment of Parkinson’s disease. It is specifically indicated for patients who are already taking carbidopa and levodopa preparations and are experiencing signs and symptoms of end-of-dose “wearing-off.” Its primary purpose is to:
Comtan begins to work quite quickly, typically with the very first dose. Because it affects how levodopa is metabolized, you should notice its effects alongside your regular carbidopa-levodopa dose. It helps prolong the action of levodopa, so the primary benefit you might notice is a longer period of symptom control before your next dose is due. The full benefit is often seen within a few days.
Yes, it is very common for Comtan to cause a harmless brownish-orange discoloration of your urine. This happens because of the way the drug is processed in your body and is not a sign of a problem. The color will return to normal if the medication is stopped. It is a well-documented and expected side effect that you should be aware of but not alarmed by.
No, Comtan is not effective on its own for treating Parkinson's disease. It is designed specifically as an add-on therapy. Its sole purpose is to inhibit the breakdown of levodopa, so it must be taken at the same time as a carbidopa-levodopa dose to have any therapeutic effect. Without levodopa, Comtan provides no benefit for Parkinson's symptoms.
If you miss a dose of Comtan, you should take your next dose as scheduled along with your next carbidopa-levodopa dose. Do not take a double dose to make up for the one you missed. The purpose of Comtan is to extend the effect of each levodopa dose, so if you miss it, you may simply notice your Parkinson's symptoms returning sooner than usual (the 'wearing-off' effect).
You can take Comtan with or without food. However, it's most important to take it at the same time as your carbidopa-levodopa dose. For best results, be consistent with how you take it. Some people find that taking it with a small meal can help reduce potential side effects like nausea. Follow your doctor's specific recommendations for administration.
You should use caution when drinking alcohol while taking Comtan. Both Comtan and alcohol can cause dizziness and drowsiness. Combining them can intensify these effects, increasing the risk of falls or accidents. It is best to discuss your alcohol consumption with your doctor, who can provide personalized advice based on your overall health and treatment plan.
Yes, Comtan can cause drowsiness and sleepiness. In some cases, people have reported falling asleep suddenly during daily activities. For this reason, you should be cautious when driving, operating machinery, or performing any other task that requires alertness until you know how the medication affects you. Inform your doctor if you experience excessive daytime sleepiness.
Yes, hallucinations are a possible side effect of Comtan, as with other dopaminergic drugs used for Parkinson's disease. These can involve seeing, hearing, or feeling things that are not there. This risk may be higher in elderly patients. If you or a family member notices this or any other significant changes in your thinking or behavior, you should contact your doctor right away.
No, Comtan does not cure Parkinson's disease. It is a symptomatic treatment that helps manage the motor symptoms of the condition more effectively. By extending the effectiveness of levodopa, it helps improve quality of life by reducing 'off' time and improving motor function. It is part of a long-term management strategy, not a cure for the underlying disease.
Comtan should be stored at room temperature, typically between 68-77°F (20-25°C), away from excess moisture, heat, and direct light. Keep the medication in its original container with the lid tightly closed. As with all prescription drugs, it is crucial to keep Comtan out of the reach of children and pets to prevent accidental ingestion.
Comtan can cause orthostatic hypotension, which is a form of low blood pressure that happens when you stand up from a sitting or lying position. This can make you feel dizzy, lightheaded, or even faint. The effect is usually most noticeable when you first start the medication. To minimize this, always rise slowly and be sure to inform your doctor about this or any other side effects.
You should not stop taking Comtan suddenly without first talking to your healthcare provider. Abruptly stopping the medication can lead to a rare but serious condition similar to Neuroleptic Malignant Syndrome (NMS), with symptoms like high fever, muscle rigidity, and confusion. Your doctor will provide guidance on how to safely discontinue the medication if needed.
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