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For visual reference only; actual product may vary

  • US Name:

    Orilissa

  • Alternative Names:

    Orilissa

  • Active Ingredients:

    Elagolix

  • Brand Manufacturer:

    Abbvie

  • Manufacturer Location:

    USA

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  • Click here to view Product Insert

Orilissa *

For visual reference only; actual product may vary

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Orilissa (Elagolix) is a prescription oral medication specifically designed to manage moderate to severe pain caused by endometriosis. This once-daily pill is clinically proven to reduce symptoms, including painful periods and chronic pelvic pain, offering a new option for women seeking relief.

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Orilissa Brand 150mg
28 Tablets
-
+
Our price:
$827.00
Orilissa Brand 200mg
56 Tablets
-
+
Our price:
$1,551.00

*Please note all prices are in US dollars

What is Orilissa?

Orilissa is an oral prescription medication used to manage moderate to severe pain associated with endometriosis. Its active ingredient, elagolix, is the first of its kind—an oral gonadotropin-releasing hormone (GnRH) antagonist developed specifically for this condition. Endometriosis occurs when tissue similar to the uterine lining grows outside the uterus, causing chronic pain and inflammation. Orilissa works to reduce this pain by managing the body’s production of estrogen. This medication offers a way for women to control their symptoms through a daily pill, providing a significant alternative to other treatments. It is not a hormonal contraceptive but can affect your menstrual cycle.

How does Orilissa work?

Orilissa works by lowering the levels of estrogen in the body, a hormone that fuels the growth of endometriosis tissue. It does this by blocking a hormone in the brain called GnRH (gonadotropin-releasing hormone). By blocking GnRH, Orilissa tells the pituitary gland to produce less of the hormones that stimulate the ovaries. This leads to a decrease in estrogen production. With less estrogen, the endometriosis implants are less stimulated. This helps to reduce the inflammation and pain they cause, including painful periods and chronic pelvic pain between periods. The effect is temporary and reversible after stopping the medication.

Who is Orilissa for?

Orilissa is intended for premenopausal women who have been diagnosed with moderate to severe endometriosis. This medication is for women who experience significant pain that impacts their daily lives. It is often prescribed when other treatments, such as over-the-counter pain relievers (NSAIDs) or hormonal birth control, have not provided enough relief. Orilissa is not for women who are pregnant, trying to become pregnant, or breastfeeding. Because it can cause bone loss, its use is limited in duration. Your doctor will decide if Orilissa is the right choice for you after discussing your symptoms, medical history, and treatment goals.

Dosage and administration

Orilissa dosage and administration depend on the severity of your symptoms and your doctor’s recommendation. This medication is an oral tablet that you should take once a day, at about the same time each day. It can be taken with or without food. The tablets are available in two strengths: 150 mg and 200 mg. The lower dose may be taken for up to 24 months, while the higher dose is typically limited to 6 months of use. If you miss a dose, take it as soon as you remember on the same day. Do not take two doses at once to make up for a missed one. Always follow your doctor’s instructions exactly.

Side effects

Orilissa may cause side effects, with the most common ones related to lower estrogen levels. These can include hot flashes, night sweats, headaches, nausea, and changes in your menstrual cycle like lighter or stopped periods. Some people may also experience mood changes, anxiety, joint pain, or difficulty sleeping. A more serious side effect is a decrease in bone mineral density (bone loss), which is why treatment length is limited. Other serious but less common risks include elevated liver enzymes and suicidal thoughts. It is important to discuss any side effects you experience with your doctor.

Why buy from IsraelPharm?

IsraelPharm provides a secure and affordable way for you to purchase Orilissa online. We are committed to making essential medications accessible and affordable. Our platform makes it easy to order your prescription from the comfort of your home. We source all our medications from licensed pharmacies, ensuring you receive genuine products. Our knowledgeable customer service team is available to assist you with any questions. With competitive pricing and discreet shipping directly to your door, IsraelPharm is a trusted partner in managing your health, helping you get the relief you need without the high cost.

The most common side effects of Orilissa include:

  • Hot flashes and night sweats
  • Headache
  • Nausea
  • Difficulty sleeping (insomnia)
  • Absence of menstrual periods (amenorrhea)
  • Anxiety and mood changes
  • Joint pain

More serious side effects can occur. These include a dose-related decrease in bone mineral density (bone loss), changes in liver function, and rare instances of suicidal thoughts or behavior. Discuss all potential risks with your doctor.

Orilissa is indicated for the management of moderate to severe pain associated with endometriosis. This includes relief for several types of pain:

  • Painful periods (dysmenorrhea)
  • Pelvic pain that occurs between periods (non-menstrual pelvic pain)
  • Pain during sexual intercourse (dyspareunia)

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