For visual reference only; actual product may vary
For visual reference only; actual product may vary
Syfovre (pegcetacoplan) is a prescription injection used to treat geographic atrophy (GA) from age-related macular degeneration. Administered by a specialist, it works by slowing lesion growth to help preserve your eyesight. This medication requires cold chain shipping to maintain its effectiveness and ensure patient safety.
| Syfovre Brand | 150mg/ml 1 Syringes |
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Our price: $4,530.00 |
Syfovre is an injectable prescription medicine used to treat geographic atrophy (GA). This condition is an advanced, or “dry,” form of age-related macular degeneration (AMD). Geographic atrophy causes progressive and irreversible vision loss. Syfovre is administered directly into the eye by a qualified retinal specialist. Its purpose is to slow down the progression of the disease. By slowing the growth of retinal lesions, it helps preserve central vision for longer. This targeted treatment represents a significant advancement for patients with GA.
Syfovre works by targeting a part of the immune system called the complement cascade. Overactivation of this system is believed to play a key role in the development of AMD and GA. Syfovre is a pegylated peptide that specifically binds to and inhibits complement proteins C3 and C3b. By blocking this pathway, Syfovre helps reduce the inflammation and cell damage that leads to the death of retinal cells. This mechanism slows the rate at which GA lesions grow. It does not cure the condition but can delay vision loss.
Syfovre is for patients who have been diagnosed with geographic atrophy secondary to age-related macular degeneration. It is intended for individuals looking to slow the progression of this chronic eye disease. Patients must be able to receive regular injections into their eye. This procedure is performed by a healthcare professional in a clinical setting. It is not for people with infections in or around their eye. A thorough examination by an ophthalmologist will determine if you are a suitable candidate for this treatment.
Syfovre is administered as an intravitreal injection, meaning it is injected into the vitreous humor of the eye. The standard dose is 15 mg in a 0.1 mL solution. This injection is given by a retina specialist. The dosing schedule is typically once every 25 to 60 days in each affected eye. Your doctor will determine the appropriate frequency based on your condition. Before the injection, the doctor will numb your eye and clean the area to prevent infection. Your eye pressure will be monitored after the procedure.
Syfovre may cause some side effects, which are mostly related to the injection itself. Many are temporary and mild. However, more serious side effects can occur. It is important to discuss these risks with your doctor. After an injection, you should report any signs of increasing eye pain, vision changes, or discharge to your doctor immediately. This could indicate a serious complication like an infection.
IsraelPharm provides a secure and affordable source for purchasing your essential medications like Syfovre. We are committed to patient safety and providing access to authentic, brand-name drugs. Our streamlined online ordering process is simple and convenient. We offer competitive pricing to help you manage treatment costs. Our customer service team is available to assist you with any questions. We ensure your medication is stored and shipped according to strict standards, including required cold chain logistics for sensitive products like Syfovre. Trust us for your vision care needs.
The most common side effects associated with Syfovre are often temporary and related to the eye injection. They include:
In rare cases, more serious side effects can occur, such as:
Syfovre is primarily indicated for the treatment of:
Syfovre begins to work immediately after the first injection to slow the progression of geographic atrophy. However, its effects are not about reversing damage but about slowing down future lesion growth. Patients will likely not feel a change in their vision. The primary goal is to preserve existing sight for as long as possible. Your doctor will monitor the progress of the disease at your regular appointments to assess the treatment's effectiveness over several months.
A Syfovre injection should not be painful because your doctor will use strong anesthetic eye drops to numb the surface of your eye completely. You might feel a slight pressure sensation during the injection, but sharp pain is uncommon. After the anesthetic wears off, it is normal to experience some mild discomfort, scratchiness, or irritation for a day or two. Your doctor will advise on how to manage this.
Driving home after a Syfovre injection is generally not recommended. Your eye may be dilated for the examination, and your vision might be blurry immediately following the procedure. It is safest to arrange for someone else to drive you home from your appointment. Your vision should return to its baseline level within a day, but you should follow your doctor's specific instructions after treatment.
Syfovre must be stored in a refrigerator between 2°C to 8°C (36°F to 46°F) in its original carton to protect it from light. It must not be frozen. Due to these strict temperature requirements, Syfovre is shipped via a cold chain process to ensure it remains stable and effective from the pharmacy until it reaches your doctor's office for administration. Improper storage can compromise the medication's safety and efficacy.
If you miss a scheduled appointment for your Syfovre injection, you should contact your retina specialist as soon as possible to reschedule. Consistent treatment is important to achieve the maximum benefit of slowing disease progression. Missing a dose may interrupt this process. Your doctor will determine the best way to get you back on your treatment schedule. Do not wait for your next regularly scheduled appointment.
Syfovre does not cure geographic atrophy and cannot reverse existing damage or restore lost vision. Its purpose is to slow down the rate at which the disease progresses. By inhibiting the complement cascade, Syfovre reduces the speed at which retinal cells are lost. This can help preserve your remaining central vision for a longer period. It is a treatment to manage the disease, not a cure for it.
Using other eye drops with Syfovre is generally acceptable for most patients, such as drops for dry eye or glaucoma. However, it is essential to tell your doctor about all medications you are using. On the day of your injection, your doctor will likely provide specific instructions about which drops to use or avoid before and after the procedure to prevent contamination and ensure the best outcome.
Syfovre injections carry a small risk of a serious eye infection known as endophthalmitis. You must contact your doctor immediately if you experience worsening eye pain, increased redness, significant vision changes or loss, increased sensitivity to light, or any discharge from the eye. These symptoms can appear one to two days after the injection and require urgent medical attention to prevent permanent vision loss.
Syfovre is typically administered by a retina specialist once every 25 to 60 days. Your doctor will create a personalized dosing schedule based on the severity of your geographic atrophy and how your eyes respond to the treatment. Regular follow-up appointments are crucial to monitor the disease and adjust the treatment interval as needed. The goal is to provide consistent therapy to slow vision loss.
Syfovre is one of the first approved treatments for geographic atrophy. Another medication, Izervay (avacincaptad pegol), works in a similar way by targeting the complement system and is also an option. Previously, there were no approved drugs, and management focused on low-vision aids and monitoring. You should discuss all available treatment options, including their risks and benefits, with your retina specialist to determine which is best for you.
Syfovre can cause temporary vitreous floaters, which may appear as small specks, dots, or lines moving in your field of vision. This is a common and usually harmless side effect related to the injection of medication into the gel-like vitreous of the eye. These floaters typically diminish and resolve on their own over a few days. However, a sudden increase in floaters, especially with flashes of light, should be reported to your doctor.
Syfovre should not be used in certain individuals. People with an active infection in or around the eye, or those with significant intraocular inflammation, are not suitable candidates. Additionally, anyone with a known hypersensitivity or allergy to pegcetacoplan or any of the other ingredients in Syfovre must avoid this treatment. A comprehensive eye exam and medical history review are necessary to confirm your eligibility for the drug.
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