For visual reference only; actual product may vary
For visual reference only; actual product may vary
Pulmozyme (dornase alfa) is an inhaled medication used to manage cystic fibrosis. It works by thinning the thick mucus in the lungs, making it easier to breathe and cough up. Administered daily with a nebulizer, this therapy helps improve overall lung function and reduce the frequency of respiratory infections in patients.
| Pulmozyme Brand | 2.5mg 30 Ampoules |
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Our price: $850.00 |
Pulmozyme is an inhaled medication containing the active ingredient dornase alfa. It is a specialized enzyme designed to treat cystic fibrosis (CF). This medication works as a mucolytic, meaning it thins and loosens mucus. In people with CF, the mucus in the lungs becomes very thick and sticky. This blockage makes it difficult to breathe. It also creates an environment where bacteria can thrive, leading to frequent infections. Pulmozyme helps manage these symptoms by making mucus easier to clear from the airways.
Pulmozyme works by breaking down excess DNA in the mucus of the lungs. In cystic fibrosis, numerous white blood cells gather in the airways to fight infection. When these cells break down, they release DNA, which makes the mucus extremely thick and sticky. Pulmozyme contains dornase alfa, a manufactured version of a natural human enzyme. This enzyme specifically targets and cuts the long strands of DNA into smaller pieces. This process significantly reduces the thickness of the mucus. As a result, the thinned mucus is much easier to cough up and clear from the lungs. This action improves airflow and overall lung function.
Pulmozyme is designed for patients with cystic fibrosis to help manage their symptoms. It is approved for use by both adults and children aged five and older. This medication is rarely used alone. Instead, it is part of a comprehensive CF treatment plan. This plan often includes chest physiotherapy, antibiotics, and other medications. Pulmozyme is for patients who need help clearing thick secretions from their airways. It is particularly beneficial for those with a forced vital capacity (FVC) of at least 40% of the predicted value. Your doctor will determine if this medication is right for you.
Pulmozyme is typically administered as a single daily dose through a nebulizer. The medication comes in single-use ampoules containing 2.5 mg of dornase alfa in 2.5 mL of solution. The full content of one ampoule is emptied into the nebulizer cup. The patient then inhales the medicated mist. It is critical to use a compatible nebulizer and compressor system recommended by your doctor. Do not dilute or mix Pulmozyme with any other drugs in the nebulizer. Always follow your healthcare provider’s specific instructions for use. Ampoules should be stored in the refrigerator and protected from light.
Pulmozyme may cause side effects, though many users experience none or only mild ones. The most common side effects are related to the administration route. These can include changes to your voice or hoarseness. You might also experience a sore throat, runny nose, or a rash. Some people report chest pain or red, irritated eyes (conjunctivitis). These effects are usually temporary and manageable. More serious side effects are rare but can include severe breathing difficulty. You should contact your doctor if any side effect becomes severe or does not go away. Seek immediate help for signs of an allergic reaction.
IsraelPharm offers a reliable and convenient way to purchase your Pulmozyme prescription. We provide access to authentic medications sourced from a regulated supply chain. Our competitive pricing helps you save money on your long-term cystic fibrosis therapy. Ordering from our user-friendly online platform is simple and secure. Your medication is shipped directly to your door in discreet packaging. Our knowledgeable customer service team is ready to assist you with any questions. Trust IsraelPharm to be your partner in managing your health with affordable and accessible medication.
Pulmozyme may cause side effects, which are typically mild to moderate. Not everyone will experience them. Always consult a healthcare provider for medical advice.
Seek immediate medical attention if you experience signs of a severe allergic reaction, such as:
Pulmozyme is used to help manage cystic fibrosis (CF) in adult and pediatric patients. It is an adjunctive therapy intended to improve pulmonary function.
Pulmozyme ampoules must be stored in the refrigerator at 2°C to 8°C (36°F to 46°F) and kept in their foil pouch to protect them from light. You should not freeze the medication. Because they are for single-use and contain no preservatives, any opened and unused solution must be discarded immediately. For short periods, such as during travel, you may keep unopened ampoules at room temperature for up to 24 hours.
Pulmozyme should not be diluted or mixed with any other drugs in your nebulizer. Combining medications can alter their chemical properties and reduce their effectiveness or increase the risk of side effects. You should always administer each of your inhaled therapies separately, following the order prescribed by your doctor. This ensures that you get the full therapeutic benefit from your Pulmozyme treatment as intended.
If you miss a dose of Pulmozyme, you should take it as soon as you remember. However, if it is almost time for your next scheduled dose, you should skip the missed one. Do not take a double dose of the medication to make up for the one you missed. Maintaining a consistent daily schedule will provide the best results for managing your cystic fibrosis symptoms and improving your lung function over time.
Pulmozyme is considered safe and effective for use in children aged five years and older who have cystic fibrosis. Its safety and efficacy have not been established in children under the age of five. The standard dosage for children is typically the same as for adults: one 2.5 mg single-use ampoule inhaled once daily. Always follow the specific instructions and guidance provided by your child’s pediatric pulmonologist or healthcare team.
Pulmozyme does not cure cystic fibrosis, which is a genetic condition. Instead, it is a chronic maintenance therapy designed to manage the respiratory symptoms of the disease. It works by thinning mucus, which helps to improve lung function, make breathing easier, and reduce the frequency of lung infections. This treatment is one part of a comprehensive care plan that helps improve the quality of life for people living with CF.
Pulmozyme can be taken at any time of day, but it is important to be consistent and use it at the same time each day. Many patients find it beneficial to coordinate their treatment with their airway clearance routine, such as chest physiotherapy. Using Pulmozyme about 30 minutes before clearance techniques can make it easier to cough up the thinned mucus. You should discuss the optimal timing with your healthcare provider.
Pulmozyme may initially make you cough more, and this is often a sign that the medication is working correctly. The drug thins the thick, sticky mucus in your lungs, and coughing is your body’s natural way of clearing it out more effectively. This productive cough helps improve lung function. If your coughing is severe, painful, or accompanied by other concerning symptoms, you should consult your healthcare provider for advice.
Pulmozyme begins to work on thinning mucus shortly after the first dose is inhaled. However, noticeable improvements in breathing and lung function may take several days to a week of consistent daily use. The full benefits of the therapy, such as a reduction in respiratory infections, are typically seen over several months. Consistent, long-term use is key to achieving the best possible outcomes with this medication for managing cystic fibrosis.
Yes, Pulmozyme should be administered using a recommended jet nebulizer and compressor system. Examples of validated systems include the Hudson RCI UP-DRAFT II, Acorn II, PARI LC PLUS, or PARI BABY. Ultrasonic nebulizers are not recommended as they may not deliver the medication effectively and can damage the enzyme. Always consult your doctor or pharmacist to ensure you are using a compatible device for your treatment.
You can travel with Pulmozyme, but you must plan ahead to ensure it is stored correctly. The ampoules should be kept refrigerated whenever possible. For short trips, they can be kept at room temperature (up to 25°C or 77°F) for a total of 24 hours. Use a cooler with ice packs for longer journeys. Always carry your medication in your carry-on luggage, along with your prescription information, when flying.
The most common side effects associated with Pulmozyme often involve the throat and voice. Patients may experience hoarseness (voice alteration), a sore throat, or laryngitis after inhaling the medication. Other possible side effects include a skin rash, chest pain, and conjunctivitis (pink eye). These effects are generally mild and may decrease over time. If any side effect is persistent or bothersome, you should notify your doctor.
Pulmozyme and hypertonic saline are both inhaled mucolytics but work in different ways. Pulmozyme is an enzyme that directly breaks down DNA to thin mucus. Hypertonic saline is a sterile, high-concentration salt solution that works by drawing water into the airways through osmosis, which helps to hydrate and loosen mucus. Your doctor may prescribe one or both of these therapies as part of your comprehensive cystic fibrosis treatment plan.
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