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For visual reference only; actual product may vary
For visual reference only; actual product may vary
Ajovy (Fremanezumab) is an injectable prescription medication used for the preventive treatment of migraine headaches in adults. It helps reduce the frequency of migraine days with a flexible monthly or quarterly dosing schedule. This product requires cold chain shipping.
| Ajovy Brand | 225mg/1.5mL 1 Pre-Filled Pen |
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Our price: $850.00 |
Ajovy (fremanezumab) is an injectable prescription medicine used for the preventive treatment of migraine in adults. It is a modern medication designed specifically to reduce the frequency and severity of migraine headaches, helping patients regain control over their lives. Unlike treatments taken at the onset of a migraine, Ajovy is administered on a regular schedule to stop migraines before they start. It belongs to a class of drugs called calcitonin gene-related peptide (CGRP) inhibitors and is available in a pre-filled autoinjector or syringe for easy self-administration.
Ajovy works by targeting and blocking the activity of calcitonin gene-related peptide (CGRP), a protein in the brain and nervous system. CGRP is known to play a crucial role in the process of a migraine attack; its levels increase during a migraine, and it is involved in transmitting pain signals and dilating blood vessels, which contribute to the intense headache. By binding to the CGRP ligand, Ajovy prevents it from attaching to its receptors, thereby inhibiting its effects and helping to prevent the cascade of events that lead to a migraine attack.
Ajovy is for adults who are diagnosed with either chronic or episodic migraine and are looking for a proactive way to manage their condition. It is often prescribed for individuals who experience four or more migraine days per month and may be a good option for those who have not responded well to, or cannot tolerate, other oral preventive medications. The choice between monthly and quarterly dosing also makes it a flexible option for patients with different lifestyle needs, providing a long-term strategy for migraine management rather than just treating symptoms as they appear.
Ajovy is administered as a subcutaneous (under the skin) injection and offers two dosing options for patients. You can choose a 225 mg injection once per month or a 675 mg injection (three consecutive 225 mg injections) once every three months (quarterly). The choice of dosing schedule should be made with your healthcare provider. The injection can be given in the abdomen, thigh, or the back of the upper arm. Your doctor or nurse will show you how to properly use the pre-filled autoinjector or syringe so you can administer the medication yourself at home.
The most common side effects associated with Ajovy are injection site reactions. Patients may experience pain, redness, swelling, itching, or hardening of the skin where the injection was given. These reactions are typically mild to moderate and usually resolve on their own. Serious allergic reactions (hypersensitivity) are rare but possible. If you experience symptoms like a rash, hives, swelling of the face or tongue, or difficulty breathing after an injection, you should seek emergency medical care immediately. Always discuss potential side effects with your doctor before starting treatment.
IsraelPharm is your trusted source for authentic, brand-name medications like Ajovy at competitive prices. We are committed to making essential treatments more accessible and affordable for patients in the United States. Our licensed pharmacy team ensures that every medication, including temperature-sensitive products like Ajovy, is dispensed and shipped according to the highest safety and quality standards. With our user-friendly online platform and dedicated customer support, you can confidently and conveniently manage your migraine treatment from the comfort of your home.
Like all medications, Ajovy can cause side effects, although not everyone will experience them. The most common side effects are related to the injection site.
Common side effects may include:
Less common but more serious side effects can include:
This is not a complete list of possible side effects. Consult your doctor for medical advice about adverse effects and discuss any concerns you may have before starting treatment.
Ajovy is indicated for the preventive treatment of migraine in adults.
It is designed for patients who experience frequent migraines and aims to reduce the number of migraine days each month. It can be a suitable option for those with either episodic or chronic migraine.
Ajovy is a preventive medication, so it does not work instantly to stop a migraine that has already started. Most patients in clinical trials began to see a reduction in their number of monthly migraine days within the first month of treatment. You may notice improvements over the first few weeks, with the full benefits often becoming more apparent after two to three months of consistent use.
Yes, you can and should use your acute migraine medication (like triptans or NSAIDs) as prescribed by your doctor to treat a migraine attack when it occurs. Ajovy is a preventive therapy designed to reduce the number of migraine days you have, but it does not treat the symptoms of an active migraine. Always follow your doctor’s guidance on managing breakthrough attacks.
Ajovy is given as a subcutaneous injection, meaning it is injected into the fatty tissue just under the skin. The most common injection sites are the abdomen (avoiding the two inches around the navel), the front of your thighs, or the back of your a an arm. You should rotate your injection sites with each dose to avoid skin irritation.
If you miss your monthly or quarterly dose of Ajovy, you should administer it as soon as you remember. After that, you will need to adjust your schedule. Your next dose should be taken either one month or three months after the date you took the missed dose, depending on your prescribed regimen. If you are unsure what to do, contact your healthcare provider for advice.
Ajovy must be refrigerated between 36°F to 46°F (2°C to 8°C) in its original carton to protect it from light. Do not freeze it. If necessary, it can be kept at room temperature (up to 86°F or 30°C) for up to 7 days. Once stored at room temperature, do not put it back in the refrigerator. Discard it if it is not used within 7 days.
Before injecting, take Ajovy out of the refrigerator and let it sit at room temperature for about 30 minutes to warm up, as a cold injection can be more painful. Do not try to warm it up using a heat source like hot water or a microwave. Always inspect the liquid to ensure it is clear to slightly yellow and does not contain particles.
Ajovy is available in two forms: a pre-filled autoinjector and a pre-filled syringe. Both contain the same medication and dosage. The autoinjector is designed for ease of use, with a simple push-down mechanism and a click to signal the injection is complete. Your doctor can help you decide which device is the best fit for your comfort and needs.
No, you cannot use Ajovy to treat a migraine that has already started. Ajovy is a prophylactic (preventive) treatment, not an abortive one. Its purpose is to reduce the number of migraines you experience over time. For acute attacks, you should use the rescue medications prescribed by your healthcare provider.
The most common side effects are injection site reactions, such as pain, redness, and swelling where the shot was given. These are usually mild and temporary. Serious side effects are rare but can include a significant allergic reaction (hypersensitivity). If you experience hives, rash, or trouble breathing, seek medical help immediately. Always discuss potential risks with your doctor.
You should inform your doctor about all the medications you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. Currently, there are no specifically known major drug interactions with Ajovy. However, providing a complete list of your medications helps your doctor ensure your treatment plan is safe and effective.
Your doctor will help you decide between a monthly or quarterly dose based on your migraine frequency, lifestyle, and personal preference. The monthly option (225 mg) provides a steady dose, while the quarterly option (675 mg) may be more convenient for those who prefer fewer injections. Both have been shown to be effective at reducing migraine days.
You should not use Ajovy if you have a known allergy or hypersensitivity to fremanezumab or any of the other ingredients in the medication. It is also important to tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the effects of Ajovy in these situations have not been fully studied.
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