What is Lonsurf?
Lonsurf is a prescription combination chemotherapy drug used to treat advanced cancers. It contains two active ingredients: trifluridine and tipiracil. This medication is approved for patients with metastatic colorectal cancer. It is also used for metastatic gastric cancer, including adenocarcinoma of the gastroesophageal junction. Lonsurf is usually considered after other types of chemotherapy or targeted therapies have stopped working. It belongs to a class of drugs known as nucleoside metabolic inhibitors.
How does Lonsurf work?
Lonsurf works through a dual-action process to fight cancer cells. The first component, trifluridine, is a nucleoside analog. It incorporates itself into the DNA of cancer cells. This action disrupts the DNA’s function and prevents the cells from dividing. The second component, tipiracil, plays a supportive role. It stops an enzyme that would normally break down trifluridine. This allows trifluridine to stay in the body longer at higher concentrations. The result is a more powerful anti-cancer effect.
Who is Lonsurf for?
Lonsurf is for specific adult patients with advanced stages of cancer. It is intended for individuals with metastatic colorectal cancer. These patients have typically already undergone treatment with other standard chemotherapies. Lonsurf is also approved for adults with metastatic gastric cancer or gastroesophageal junction adenocarcinoma. The medication provides a valuable treatment option for those whose disease has progressed despite prior treatments. A doctor will determine if Lonsurf is a suitable choice based on a patient’s medical history.
Dosage and administration
Lonsurf dosage and administration must be determined by a healthcare professional. The medication comes as oral tablets. It is taken twice a day, usually for five days a week, followed by two days of rest. This is repeated for two weeks, followed by a two-week rest period. This 28-day cycle continues as long as the treatment is beneficial and tolerated. The exact dose depends on body surface area and blood test results. Patients should swallow the tablets whole with a glass of water after meals.
Side effects
Lonsurf can cause side effects, ranging from mild to severe. Common side effects include fatigue, nausea, vomiting, and diarrhea. Patients may also experience a loss of appetite and a decrease in white blood cells (neutropenia), red blood cells (anemia), and platelets (thrombocytopenia). Serious side effects can include severe bone marrow suppression. This may lead to life-threatening infections and bleeding. Your doctor will monitor your blood counts closely throughout treatment. Report any fever, chills, or unusual bleeding to your doctor immediately.
Why buy from IsraelPharm?
IsraelPharm offers a reliable and affordable way to access your medication. We source our products from licensed distributors, ensuring you receive authentic Lonsurf. Our streamlined international pharmacy service allows you to save on prescription costs without compromising quality. With a focus on patient care, our team is available to assist you with your order. We provide clear pricing and discreet shipping directly to your home. Choose IsraelPharm for a trusted source for your essential cancer treatments.
Lonsurf is indicated for the treatment of adult patients with:
- Metastatic colorectal cancer (mCRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy.
- Metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma previously treated with at least two prior lines of chemotherapy that included a fluoropyrimidine, a platinum, either a taxane or irinotecan, and if appropriate, HER2/neu-targeted therapy.