Contrave (
generic name: bupropion/naltrexone hydrochloride) is a prescription medication for adults designed to aid in weight management. It is intended for individuals with a body mass index (BMI) of 27 or higher (overweight) accompanied by weight-related health conditions or a BMI of 30 or higher (obese).
Contrave combines two active ingredients:
bupropion and
naltrexone. Bupropion is an antidepressant that can decrease appetite, while naltrexone is typically used to block the effects of opioids or alcohol in individuals with addiction issues. Together, they work on the central nervous system to
suppress appetite and reduce cravings, thereby assisting in weight loss.
Contrave belongs to the pharmacological class of
anorexiants, which are medications that suppress appetite.
Critical Warnings
- Bupropion, one of the components of Contrave, has been associated with an increased risk of suicidal thoughts or actions in some individuals. Patients should be monitored for any changes in mood or behavior.
- There is a risk of seizures with Contrave, especially in individuals with pre-existing medical conditions, including epilepsy, eating disorders such as anorexia and bulimia, or people with a history of head trauma or brain injury. If a seizure occurs, discontinue use and seek medical attention immediately. As well, those taking specific medications, including antipsychotics (e.g., chlorpromazine, clozapine), tricyclic antidepressants (e.g., amitriptyline), theophylline (used for asthma and COPD), or corticosteroids should only be taking Contrave if the prescribing doctor was aware of this beforehand.
- Naltrexone can increase the risk of opioid overdose if opioids are used concurrently. Patients should avoid opioid medications while taking Contrave and inform their healthcare provider of any opioid use.
- Women who are pregnant, nursing, or planning to become pregnant should not take Contrave. If already taking Contrave, they should discuss stopping the medication with their doctor before trying to conceive.
Dosage
The standard dosing regimen for Contrave involves a gradual increase over four weeks:
- Week 1: One tablet in the morning.
- Week 2: One tablet in the morning and one in the evening.
- Week 3: Two tablets in the morning and one in the evening.
- Week 4 and beyond: Two tablets in the morning and two in the evening.
It’s important to swallow the tablets whole without cutting, chewing, or crushing them. If a dose is missed, wait until the next scheduled time to take it; do not double up on doses.
Storage
Store Contrave at room temperature, away from excessive heat and moisture. Ensure the medication is kept out of reach of children and pets.
Get more advice about safe drug storage from our blogs.
Frequently Asked Questions (FAQs)
How does Contrave aid in weight loss?
Contrave combines bupropion and naltrexone to target areas of the brain involved in controlling appetite and cravings, helping to reduce hunger and assist with weight loss.
How long does it take to see results with Contrave?
Weight loss results can vary among individuals. It’s important to follow a reduced-calorie diet and increase physical activity while taking Contrave to achieve the best results. Consult with your healthcare provider for personalized guidance.
Are there any dietary restrictions while taking Contrave?
It’s recommended to avoid high-fat meals when taking Contrave, as they can increase the risk of seizures. Following a balanced, reduced-calorie diet is advised.
8. Is Contrave a controlled substance?
No, Contrave is not classified as a controlled substance.
9. How should Contrave be stored?
Store Contrave at room temperature, away from heat and moisture. Keep it out of reach of children and pets.
10. What should I do if I experience side effects?
If you experience any side effects, especially severe or concerning ones, contact your healthcare provider promptly. They can provide guidance on managing side effects or adjusting treatment if necessary.
11. Can Contrave be used long-term?
Contrave is intended for long-term use as part of a comprehensive weight management plan, including diet and exercise. Regular follow-ups with your healthcare provider are essential to monitor progress and assess the continued appropriateness of the medication.
12. Does Contrave interact with birth control pills?
There is no specific evidence suggesting that Contrave interacts with hormonal contraceptives. However, it’s important to inform your healthcare provider about all medications you are taking to ensure safety.
For more detailed information, please refer to the
Contrave Patient Information leaflet provided by the company
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Common Questions About Contrave
This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication.Â
Read the information leaflet that comes with the medication.
Most people who use Contrave do not experience any adverse side effects. Doctors prescribe this medication because they assess the benefits of such treatment outweigh any likely unwanted effects.
Some of the side effects that have been reported include:
- Nausea
- Headache
- Constipation
- Dizziness
- Dry mouth
- Insomnia
Not all side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.
Contrave is approved for chronic weight management in adults who are either obese or overweight with at least one weight-related condition, such as hypertension, type 2 diabetes, or dyslipidemia.
