What is Ongentys?
Ongentys is a prescription medication used to treat Parkinson’s disease. It is specifically an add-on treatment for adults experiencing “off” episodes. These episodes are periods when Parkinson’s symptoms return between doses of other medications. Ongentys helps to make your primary medication, levodopa, work more consistently. This reduces the frequency of motor fluctuations. The goal is to provide smoother control over your symptoms throughout the day. It is not a standalone treatment for Parkinson’s.
How does Ongentys work?
Ongentys works by blocking an enzyme called COMT (catechol-O-methyltransferase). This COMT enzyme naturally breaks down levodopa in your body. Levodopa is a primary medication that your brain converts into dopamine. By inhibiting the COMT enzyme, Ongentys allows more levodopa to reach the brain. This extends the effects of each levodopa dose. It helps to stabilize dopamine levels. This action leads to a reduction in “off” time for people with Parkinson’s. It is a selective and reversible inhibitor, taken once a day.
Who is Ongentys for?
Ongentys is for adults who have been diagnosed with Parkinson’s disease. It is intended for patients who are already being treated with levodopa and a dopa-decarboxylase inhibitor (like carbidopa). The main group who benefit are those experiencing end-of-dose motor fluctuations. These are also known as “off” episodes. If your symptoms start to reappear before your next scheduled medication dose, Ongentys may be for you. It is not for initial treatment of Parkinson’s. Your doctor will determine if it is a suitable addition to your current therapy regimen.
Dosage and administration
Ongentys is administered as a once-daily oral capsule. It should be taken at bedtime for optimal results. You should not take food for one hour before or one hour after taking your dose. Importantly, Ongentys should also be taken at least one hour apart from your levodopa/carbidopa preparations. This timing helps ensure the medication is absorbed correctly and works effectively. Always follow your doctor’s specific instructions for dosage. Do not change your dose or stop taking the medication without consulting your healthcare provider first. Swallow the capsule whole with water.
Side effects
Ongentys may cause side effects in some individuals, though not everyone will experience them. It is important to be aware of potential reactions. Common side effects can include:
- Dyskinesia (uncontrolled, involuntary muscle movements)
- Constipation
- Dry mouth
- Dizziness
- Low blood pressure upon standing
- Hallucinations
More serious side effects can occur. These may include falling asleep during daily activities, compulsive behaviors, or severe diarrhea. You should contact your doctor immediately if you experience any concerning symptoms. They can help you manage these effects.
Why buy from IsraelPharm?
IsraelPharm offers a reliable and convenient way to purchase your essential medications like Ongentys. We provide access to brand-name pharmaceuticals from a trusted source. Our pricing is competitive, helping you save on your long-term treatment costs. We are committed to high standards of patient safety and customer service. Our team ensures that your prescriptions are handled professionally and shipped directly to your door. Choosing IsraelPharm means choosing an affordable and secure path to managing your health. We make the process simple and straightforward.
Like all medicines, Ongentys can cause side effects. Not everyone gets them. The most common side effect is dyskinesia (involuntary movements).
Other common side effects may include:
- Dizziness
- Dry mouth
- Constipation
- Orthostatic hypotension (a drop in blood pressure when standing)
- Sleep disturbances and hallucinations
Less common but serious side effects can include:
- Falling asleep during daily activities
- Impulse control disorders (such as gambling or binge eating)
- Signs of Neuroleptic Malignant Syndrome (fever, muscle rigidity)
Contact your doctor if you experience any bothersome or severe side effects.
Ongentys (Opicapone) is indicated as an add-on treatment to preparations of levodopa/DDCIs (dopa-decarboxylase inhibitors) in adult patients with Parkinson’s disease and end-of-dose motor fluctuations who cannot be stabilized on those combinations.
It helps to:
- Decrease the amount of “off” time
- Increase the amount of “on” time without troublesome dyskinesia
- Improve overall symptom control