People should not be taking semaglutide if they have Multiple Endocrine Neoplasia syndrome type 2 (MAN 2) or have any history of medullary thyroid carcinoma (MTC).
It has been found in animal studies that GLP-1RAs and similar drugs may cause thyroid tumors, including thyroid cancer. Symptoms such as a lump or swelling in the neck, trouble swallowing, hoarseness, or shortness of breath may be symptoms of thyroid cancer. It is vital to consult a healthcare provider before taking semaglutide and throughout the whole process.