As with any medicine, use of Simbrinza may cause side effects in some users. Do not be alarmed by the list of side effects. You may not suffer from any of them.Stop using the medicine and contact the doctor immediately if you experience any of the following side effects, as they could be signs of a reaction to the medicine. The frequency of allergic reaction to the medicine is unknown )it is not possible to estimate from the existing data(.∙ Serious skin effects, including rash or redness or itching of the body or the eyes.∙ Breathing difficulties.∙ Chest pain, irregular heart rate.Refer to the doctor immediately if you experience extreme fatigue or dizziness.The following side effects were observed with Simbrinza and other medicines containing brinzolamide or brimonidine alone.Common side effects – effects that occur in 1-10 in 100 users:In the eyes: Allergic conjunctivitis )eye allergy(, eye surface inflammation, eye pain, sensation of discomfort in the eye, blurred vision or visual disturbances, eye redness.General side effects: Dizziness, drowsiness, dry mouth, bad taste in mouth.Uncommon side effects – effects that occur in 1-10 in 1,000 users:In the eyes: Eye surface damage with loss of cells, inflammation of the eyelid, sediments on the surface of the eye, sensitivity to light, swelling of the eye )effect on the cornea or eyelid(, dry eyes, eye discharge, watery eyes, eyelid redness, abnormal or decreased sensation in the eye, tired eyes, reduced vision, double vision, medicine particles in the eyes.General side effects: Decreased blood pressure, chest discomfort, irregular heart rate, slow or fast heart rate, palpitations, sleeping difficulties )insomnia(, nightmares, depression, general weakness, headache, dizziness, nervousness, irritability, general feeling of discomfort, memory loss, shortness of breath, nose bleed, cold symptoms, dry throat or nose, sore throat, throat irritation, cough, runny nose, stuffy nose, sneezing, sinus infection, chest congestion, ringing in the ears, indigestion, intestinal gas or stomach ache, nausea, diarrhea, vomiting, unusual sensation in the mouth, increased skin allergy symptoms, rash, unusual sensation in the skin, hair loss, general itching, increased blood chlorine levels, or decreased red blood cell count as can be seen in blood tests, pain, back pain, muscle pain or cramps, kidney pain such as lower back pain, decreased libido, sexual dysfunction in men.Very rare side effects – effects that occur in less than 1 user in 10,000:In the eyes: Decreased pupil size.General side effects: Fainting, increased blood pressure.Side effects of unknown frequency )effects whose frequency has not been determined yet(:In the eyes: Decreased growth of eyelashes.General side effects: Tremor, decreased sensation, loss of sense of taste, abnormal liver function values as seen in blood tests, swelling of the face, joint pain, frequent urination, chest pain, swelling of the limbs, asthma.If a side effect occurs, if one of the side effects worsens or if you suffer from a side effect not mentioned in this leaflet, consult with the doctor.

The medicine is intended for the reduction of intraocular pressure in adults )over 18 years of age( in cases of glaucoma or intraocular hypertension in patients who do not fully respond to treatment for intraocular pressure with a single medicine.