Stop taking the medicine and contact your doctor immediately if:
 you experience indigestion or heartburn.
 you experience pain in the upper abdomen, vomit blood, notice blood in the stool, rectal
bleeding, intestinal inflammation, mouth ulcers.
 you suffer from allergic reactions such as rash, pruritus, skin blisters, loss of color
(pallor), swelling, wheezing or shortness of breath.
 aseptic meningitis occurs (neck stiffness, headaches, nausea or vomiting, fever,
disorientation); this effect has been reported mainly in patients with systemic lupus
erythematosus or other mixed connective tissue disease.
 Stevens-Johnson syndrome occurs (very rare), dermatitis or skin blisters, mouth or
tongue and/or ocular inflammation with increased photosensitivity, which can be severe
and accompanied by general feeling of being unwell.
6
Additional side effects:
 Nausea or vomiting, diarrhea, flatulence, constipation, worsening of colitis or Crohn’s
disease
 Gastritis
 Pancreatitis (very rare)
 Swelling, high blood pressure and heart failure
 Fever, weakness, sensation of malaise, shortness of breath, abnormal vision, headache,
abnormal sensation e.g. burning or tingling of hands or feet, depression, confusion,
hallucinations, ringing in the ears (tinnitus), dizziness (including vertigo), fatigue, tremor,
sleeping difficulties (insomnia), drowsiness
 Anemia, sore throat, fever, unexpected bleeding
 Yellowing of the skin or the white part of the eye
 Increased urinary urgency, difficulty upon urination or urine discoloration
 Changes in liver function and blood changes – can be detected only by blood tests
 Vascular inflammation (vasculitis)
 Rapid heartbeats (palpitations)
 Slightly increased risk of heart attack or stroke.

For the management of signs and symptoms of osteoarthritis and rheumatoid arthritis.